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In Memoriam

The integration of automation and data-driven methodologies offers a promising approach to accelerating materials discovery in energy storage research. Thus far, in battery research, coin-cell assembly has advanced to become nearly fully automated but remains largely disconnected from data-driven methods. To bridge the disconnect, this work presents a self-driving laboratory framework to accelerat

Across the world, human (anthropophonic) sounds add to sounds of biological (biophonic) and geophysical (geophonic) origin, with human contributions including both speech and technophony (sounds of technological devices). To characterize society’s contribution to the global soundscapes, we used passive acoustic recorders at 139 sites across 6 continents, sampling both urban green spaces and nearby

The understanding of genomics has improved tremendously during the last decades. The concept of recovery and outcome after stroke has also progressed during this time. However, the connection between genomics and stroke recovery has only begun to emerge in a more structural and comprehensive way. Different types of outcomes and recovery occur after stroke. This depends on domain of neurological de

Introduction: Occupational balance, a foundational concept in occupational therapy and science, plays a critical role in enhancing health and well-being. Recent studies have revealed its association with epidemiological factors. This study evaluated the validity and reliability of the Japanese version of the Occupational Balance Questionnaire 11 (OBQ11-J). Methods: Adhering to the COnsensus-based

Erythrina alkaloids and their central nervous system effects have been studied for over a century, mainly due to their potent antagonistic actions at β2-containing nicotinic acetylcholine receptors (nAChRs). In the present work, we report a synthetic approach giving access to a diverse set of Erythrina natural product analogues and present the enantioselective total synthesis of (+)-Cocculine and

Erythrina alkaloids were identified at the end of the 19th century and today, more than 100 members of the erythrinane family have been isolated. They are characterized by a unique tetracyclic, α-tertiary spiroamine scaffold. Herein we detail our efforts towards the development of a divergent enantioselective synthesis of (+)-dihydro-β-erythroidine (DHβE) - one of the most prominent members of thi

Antibody–enzyme complexes (AECs) are ideal molecular recognition elements for im-munosensing applications. One molecule possesses both a binding ability to specific targets and catalytic activity to gain signals, particularly oxidoreductases, which can be integrated into rapid and sensitive electrochemical measurements. The development of AECs using fragment antibodies rather than intact antibodie

Antibody–enzyme complexes (AECs) are ideal for immunosensing. Although AECs using antibody fragments can be produced by bacterial hosts, their low affinity limits their sensing applications. We have improved the affinity of AECs by combining two antibodies using Catcher/Tag systems; however, it requires multiple antibodies and an enzyme production process. In this study, to realize the production

Tendons are known to adapt their structural and mechanical properties in response to mechanical loading, but the precise mechanisms underlying this adaptation remain poorly understood. A previous study on rat Achilles tendons compared the effect of unloading (Botox injections and orthosis) with free cage activity (full loading) and revealed that unloading impaired the mechanical response and resul

Introduction: The refractory period and conduction delay of the atrioventricular (AV) node play a crucial role in regulating the heart rate during atrial fibrillation (AF). Beat-to-beat variations in these properties are known to be induced by the autonomic nervous system (ANS) but have previously not been assessable during AF. Assessing these could provide novel information for improved diagnosis

Channel sounding is a vital step in the design and deployment of wireless communication systems. In this article, we present the design and implementation of a coherent distributed massive multiple-input-multiple-output (MIMO) channel sounder operating at 5 and 6GHz with a bandwidth of 400MHz based on the NI USRP X410. Through the integration of multiple transceiver chains and radio frequency (RF)

Abstract There is a pressing need, particularly in the field of drug discovery, for general methods that will enable direct coupling of tertiary alkyl fragments to (hetero)aryl halides. Herein a uniquely powerful and simple set of conditions for achieving this transformation with unparalleled generality and chemoselectivity is disclosed. This new protocol is placed in context with other recently rThere is a pressing need, particularly in the field of drug discovery, for general methods that will enable direct coupling of tertiary alkyl fragments to (hetero)aryl halides. Herein a uniquely powerful and simple set of conditions for achieving this transformation with unparalleled generality and chemoselectivity is disclosed. This new protocol is placed in context with other recently report

This paper describes the development of a new variant of stereoselective strain-release driven reactions (formal homo [3 + 2] dipolar cycloadditions) which utilize housane (1) to construct functionalized amino alcohols and pyridine-substituted cyclopentanes in two to three steps from simple and easily available building blocks (nitrones and pyridine N-oxides respectively).

Abstract Herein we report on the decarboxylative alkenylation between alkyl carboxylic acids and enol triflates. The reaction is mediated by a dual catalytic nickel and iridium system, operating under visible light irradiation. Two competing catalytic pathways, from the excited state iridium photocatalyst, are identified. One is energy transfer from the excited state, resulting in formation of an

Introduction: Graves´ disease (GD) is the predominant cause of hyperthyroidism. Treatment options include antithyroid drugs (ATD), surgery, and radioactive iodine ablation (RI). Although thyroid peroxidase antibodies (anti-TPO) are prevalent in patients with GD, their role in driving relapse or hypothyroidism after treatment in patients with GD remains unclear. This study aimed to determine if pat

Disease-modifying therapies (DMTs) for multiple sclerosis (MS) can increase the risk of hepatitis B virus (HBV) reactivation (HBr), particularly with agents like ocrelizumab and alemtuzumab. However, studies in MS patients treated with DMTs indicate significantly lower reactivation rates compared to those with hematologic malignancies. This review discusses strategies for managing HBV in MS patien

Objectives: Iron deficiency anemia (IDA) is a common extraintestinal manifestation of inflammatory bowel disease (IBD), driven by impaired iron absorption, inflammation of intestinal mucosa and blood loss due to intestinal bleeding. Exogenous iron is indicated to correct iron deficiency, with intravenous iron preferred in patients with malabsorption or intolerance of oral iron, active bleeding, sy