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Purpose: We present clinical and laboratory data on 18 children from 12 hemophilia treatment centers in the United States, Canada, and Europe with the purpose of disseminating information regarding a recently recognized, potentially life-threatening complication of treatment in very young children with hemophilia B. Patients and Methods: Twelve hemophilia centers from the United States, Canada, an
Human activities have been marred for ages by conflicts of interest. This is no less true in the field of science. In the early years of the Nobel Prizes, little attention was focused on this aspect, but awareness steadily grew. In particular, this concerned Swedes nominated for Nobel Prizes, who were most likely themselves members of the Royal Swedish Academy of Sciences, but whose fellows at the
The aim of the study was to investigate the feasibility of optimizing prophylactic dosing of factor VIII by the use of individual pharmacokinetic data. Twenty-one patients were enrolled in a randomized cross-over study on standard dosage regimens vs. dosing according to pharmacokinetic principles. The study period was 2 x 6 months. Using single-dose pharmacokinetic data for each patient, plasma fa
We demonstrate an artificial three-dimensional (3D) electrical active human neuronal network system, by the growth of brain neural progenitors in highly porous low density electrospun poly-ε-caprolactone (PCL) fiber scaffolds. In neuroscience research cell-based assays are important experimental instruments for studying neuronal function in health and disease. Traditional cell culture at 2D-surfac
The main focus of the work presented in this thesis is on experimental studies oflaser acceleration of protons and other positive ions from solid targets. The topic is explored from three different angles: firstly, the development of diagnostics adapted to the ion pulses, secondly, the characterization of the source of the energetic particles and, finally, the application of laser-accelerated prot
The performance of X-ray and neutron grating interferometers is characterised by their visibility, which is a measure for the maximum achievable contrast. In this study we show how the real grating geometry in a grating interferometer with three gratings impacts the interference and self projection that leads to visibility in the first place. We quantify the individual contributions of wavelength
In his study of Carl Michael Bellman literary historian Gustaf Ljunggren (1823-1905) compared the Swedish poet not only to the traditional object of comnaprison, the ancient Greek poet Anacreon, but also to the Persian fourteenth-century poet Hafiz.This article revisits Ljunggren's work in light of recent discussions about world literature and the role of historical scale in literary studies. I in
Introduction The Göttingen minipig is a promising model for pharmacological safety assessment and for translational research in cardiology. We have examined the main ion currents in cardiomyocytes of the minipig heart. Methods Cardiac cells were isolated from different cardiac regions (endo-, mid- and epicardial left ventricle and right ventricle) from Göttingen minipigs and examined using the who
Den svenska föreningen för tillämpad språkvetenskap (Association Suédoise de Linguistique Appliquée, ASLA) bildades formellt i april 1966 och firade således 50 år som förening under 2016. Jubileumet uppmärksammades på olika sätt under året. I samband med ASLA-symposiet i Uppsala den 21-22 april 2016 hölls ett panelsamtal på temat om tillämpad språkvetenskap då, nu och i framtiden. I den här texten
This thesis makes a contribution the econometrics of panel data with cross-section dependence (CSD). It consists of five self-contained papers. The most popular approach to account for CSD is to attribute the co-movements of observed variables across entities to unobserved common factors and to estimate these factors via simple cross-section averages of the data. The chapters in this thesis invest
Preeclampsia is a serious pregnancy-specific condition, affecting 10 million women annually worldwide. No specific treatment is currently available. Recent studies have demonstrated abnormal production and accumulation of free fetal hemoglobin in the preeclamptic placenta, and identified subsequent leakage into the maternal circulation as an important factor in the development of preeclampsia. A r
PurposeThe purpose is to provide a structured method for prioritising among the diversity of motives and goals of stakeholders involved in city logistics.Design/methodology/approachThe paper is based on a three-year participant observation study in a city logistics project including ten stakeholders. The data relate to the understanding gained during the three years of study and nine semi-structur
Det finns planer på att bygga ett energilager i berget vid Önneslöv nära Dalby i Skåne. Berggrunden utgörs av en del av Romeleåsen och består huvudsakligen av gnejs med inslag av amfibolit och diabasgångar. Området ligger omedelbart söder om Sydstens stora bergtäkt, där det framgår att berget till stora delar är kraftigt uppsprucket med lervittrade zoner av olika storlek. I samband med byggande geThere are plans to build an energy storage in the rock at Önneslöv near Dalby in Skåne. The bedrock is of a part of Romeleåsen and mainly comprises gneiss, with elements of amphibolite and dolerite intrusions. The area is located immediately south of the Sydsten’s large rock quarry, which shows that the rock is mostly heavily fractured with clay weathered zones of different sizes. In connection wi
Bumble bees are ubiquitous creatures and crucial pollinators to a vast assortment of crops worldwide. Bumble bee populations have been decreasing in recent decades, with demise of flower resources and pesticide exposure being two of several suggested pressures causing declines. Many empirical investigations have been performed on bumble bees and their natural history is well documented, but the un
In Ref. [1], Spencer and Soldatos proposed an enhanced modelling approach for fibre-reinforced composites which accounts for the fibre-bending stiffness in addition to the directional dependency induced by the fibres. Although analytical solutions for simple geometries have been derived over the past years, often subject to specific assumptions such as small deformation kinematics, the application
