Software process analysis and improvement relies heavily on empirical research. Empirical research requires measurement, experimentation, and modeling. However, whatever evidence is gained via empirical research is strongly context dependent. Thus, it is hard to combine results and capitalize upon them for the purpose of improvement in evolving development environments. The process simulationmodel

Chaos in the chaos research: Reply to Stig Welinder, who commented in META 1989: 4 on the article Jes Wienberg, "Kaos i tiden", META 1989: 3

The successful planning, design and management of a traffic system is impossible without knowledge of how the traffic environment affects the behaviour of road users and how the behaviour is related to the main qualities of the traffic system (e.g. safety, efficiency). Automated video analysis is a promising tool for traffic behaviour research in that it enables collection of micro-level behaviour

OBJECTIVE: We have evaluated a new technique of cardiac de-airing that is aimed at a) minimizing air from entering into the pulmonary veins by opening both pleurae and allowing lungs to collapse and b) flushing out residual air from the lungs by staged cardiac filling and lung ventilation. These air emboli are usually trapped in the pulmonary veins and may lead to ventricular dysfunction, life-thr

In paper one, we investigated how the pharmacological activation and inhibition of the glucocorticoid system affects lifespan and symptoms in a mouse model for RTT. We performed a long-term drug treatment study with the GR activator corticosterone and the GR inhibitor RU486 under which we measured the lifespan and onset of RTT-like symptoms of male Mecp2-null and female Mecp2 heterozygous mice in

Recent research in the field of on-line handwriting recognition has been focused on statistical systems such as Hidden Markov Models, Neural Networks or a combination of these. There are however merits of employing an approach based on template matching. The first part of this thesis presents a new strategy for parameterization of on-line handwritten character samples. A novel efficient template m

Mitochondrial dysfunction is an important cause for neonatal liver disease. Disruption of genes encoding oxidative phosphorylation (OXPHOS) components usually causes embryonic lethality, and thus few disease models are available. We developed a mouse model for GRACILE syndrome, a neonatal mitochondrial disease with liver and kidney involvement, caused by a homozygous BCS1L mutation (232A>G). This

The observations that hormone-sensitive lipase (HSL) is located in close association to insulin granules in beta-cells and that cholesterol ester hydrolase activity is completely blunted in islets of HSL null mice made us hypothesize that the role of HSL in beta-cells is to provide cholesterol for the exocytosis of insulin. To test this hypothesis, wild type (wt) and HSL null islets were depleted

The national Swedish policy on alcohol has been eroded since the country joined the European Union (EU) in 1996, leading to a steep increase in the private import of alcohol. The paper investigates the impact on drinking patterns of the greater availability of alcohol among adolescents. Two cross-sectional data sets, collected in 2003 (n = 2,760) and 2005 (n = 2,031) in schools in southern Sweden,

Two previous clinical trials investigating hypothermia as an adjunct therapy for myocardial infarction have failed. Recently a pilot study has demonstrated a significant reduction in infarct size. The aims of this study were to elucidate the effects of hypothermia on reperfusion injury and to investigate the optimal hypothermia protocol for a future clinical trial. Pigs (40-50 kg) were anesthetize

A report from the conference Virtual City in Lund 1998.

Arterial cardiovascular disease and neighborhood deprivation are associated. However, no study has determined whether neighborhood deprivation is associated with venous thromboembolism (VTE). We aimed to determine whether there is an association between neighborhood deprivation and hospitalization for VTE, and whether effects vary across sociodemographic groups. The entire Swedish population aged

The measurement of subtle morphologic beat-to-beat variability in the electrocardiogram (ECG)/vectorcardiogram (VCG) is complicated by the presence of noise which is caused by, e.g., respiration and muscular activity. A method was recently presented which reduces the influence of such noise by performing spatial and temporal alignment of VCG loops. The alignment is performed in terms of scaling, r