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Genetic variation at the 19q13.3 KLK locus is linked with prostate cancer susceptibility in men. The non-synonymous KLK3 single nucleotide polymorphism (SNP), rs17632542 (c.536 T > C; Ile163Thr-substitution in PSA) is associated with reduced prostate cancer risk, however, the functional relevance is unknown. Here, we identify that the SNP variant-induced change in PSA biochemical activity mediates
InBi(0 0 1) is formed epitaxially on InAs(1 1 1)-A by depositing Bi onto an In-rich surface. Angle-resolved photoemission measurements reveal topological electronic surface states, close to the M high symmetry point. This demonstrates a heteroepitaxial system entirely in the III–V family with topological electronic properties. InBi shows coexistence of Bi and In surface terminations, in contradict
We present a detailed depth-sensitive study of the evolution in correlated electron behavior from the surface of the prototypical correlated oxide, SrxCa1-xVO3, to its bulk. Photoemission measurements of varying surface sensitivity are employed to directly compare both the spectral weight and energetics of the correlated electron features, and resonant soft x-ray emission spectroscopy is used as a
(Ga,Mn)As is a model diluted ferromagnet system in which the atomic spins of Mn ions are ferromagnetically arranged due to the exchange interaction with valence band holes. An important tecchnological concern regarding this system has been approaches that might result in reduction of the density of Mn interstitial and increase in the content of Mn in order to make the system practically feasible.
Poor preoperative sleep quality and impaired sleep continuity may heighten acute postoperative pain intensity and increase analgesic consumption, with negative implications for recovery, mental and physical health. The main objective of the current review was to investigate the relationship between preoperative sleep disturbance and acute postoperative pain control. Four electronic databases were
This paper is concerned with the feasibility of the power flow in DC power grids with constant power loads. We introduce the notion of distance to infeasibility as a voltage stability index and robustness measure for power flow feasibility. In particular, we study the p-norm distance to infeasibility in the domain of the constant power loads, and show how this distance may be expressed as a mathem
Purpose: Childhood cancer survivors, in particular those treated with radiation therapy, are at high risk of long-term iatrogenic events. The prediction of risk of such events is mainly based on the knowledge of the radiation dose received to healthy organs and tissues during treatment of childhood cancer diagnosed decades ago. We aimed to set up a standardized organ dose table to help former pati
In this paper we provide an analytical solution to an H2 optimal control problem, that applies whenever the process corresponds to a uniformly damped network of masses and springs. The solution covers both stable and unstable systems, and illustrates analytically how damping affects the levels of achievable performance. Furthermore, the resulting optimal controllers can be synthesised using passiv
The aerobic oxidation of carbon monoxide to carbon dioxide is catalysed by the Mo/Cu-containing CO-dehydrogenase enzyme in the soil bacterium Oligotropha carboxidovorans, enabling the organism to grow on the small gas molecule as carbon and energy source. It was shown experimentally that silver can be substituted for copper in the active site of Mo/Cu CODH to yield a functional enzyme. In this stu
Grounded in the social cognitive theory, the main aim of this study is to explore the impact of telepresence, social presence, and emotional engagement on impulsive buying tendencies within the realm of travel live-streaming (TLS). To examine further, the moderating effect of guidance shopping was included. An online questionnaire was distributed to 332 live-streaming viewers from China, and the c
This study aims to investigate the different behaviors with respect to safety measures related to the interaction of e-scooters and bikes with cars in mixed traffic. E-scooters are relatively new vulnerable road users, and their behavior is still not fully understood. For this purpose, an observational study was carried out at an unsignalized at-grade intersection in the city of Catania, Italy. A
District Heating is a cornerstone for the decarbonisation of the heating and cooling sector in Europe. Nonetheless, this technology is currently absent in a majority of the continent's urban areas, and hence the need for appropriate methods by which to estimate the cost, as well as underlying cost parameters, to assess the feasibility of developing district heating networks is of general interest.
District heating is one of the technologies that can contribute to the decarbonisation of the European heat sector. Nonetheless, these infrastructures only deliver about a tenth of the heat demands in the continent. Therefore, it is essential to assess the expansion potential of these systems and to identify which areas should be target for further investigations, which calls for easy-to-use and s
This paper presents a novel approach to modeling the gradual reduction in heat demand and the evolving expansion of district heating (DH) grids for assessing the DH potential in EU member states (MS). It introduces new methodological elements for modeling the impact of connection rates below 100% on heat distribution costs in both dense and sparse areas. The projected heat demand in 2050 is derive
