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Bulged-out nucleotides in an antisense RNA are required for rapid target RNA binding in vitro and inhibition in vivo

Naturally occurring antisense RNAs in prokaryotes are generally short, highly structured and untranslated. Stem-loops are always present, and loop regions serve as primary recognition structures in most cases. Single-stranded tails or internal unstructured regions are required for initiation of stable pairing between antisense and target RNA. Most antisense RNAs contain bulged-out nucleotides or s

The human BARX2 gene : genomic structure, chromosomal localization, and single nucleotide polymorphisms

The BARX genes 1 and 2 are Bar class homeobox genes expressed in craniofacial structures during development. In this report, we present the genomic structure, chromosomal localization, and polymorphic markers in BARX2. The gene has four exons, ranging in size from 85 to 1099 bp. BARX2 is localized on human chromosome 11q25, as determined by radiation hybrid mapping. In the mouse, Barx2 is coexpres

Sociodemographic Factors, Nutritional Status, and Inflammatory Markers in Patients with Postural Orthostatic Tachycardia Syndrome

Objectives. Postural orthostatic tachycardia syndrome (POTS) is characterized by cardiovascular autonomic dysfunction of unknown etiology with high a prevalence of gastrointestinal symptoms. The aim of the present study was to examine sociodemographic, lifestyle, and nutritional factors as well as inflammatory markers in patients with POTS. Materials and Methods. Forty-three patients with POTS and

Creating age-friendly environments in a smart society in China: a policy review

Technology is increasingly being integrated into Age-Friendly Environments (AFEs). This study explores how technology is manifested in AFE policies in China. We conducted a content analysis of 176 policies spanning seven years to identify the relationship between technology and AFEs, and the characteristics of policy development. The findings indicate that technology plays a role in advancing a sm

Manner Modifiers as Syntactic Heads

The present dissertation concerns typologically unusual ways of encoding manner information, namely verbal affixes (manner affixes), incorporated constituents (incorporated manner modifiers) and auxiliary verbs (manner adverbial verbs). A key proposal is that all three are overt realizations of syntactic heads merged in the clausal spine, thereby presenting novel data that can be used to probe int

Water level fluctuation induced variation of sulfamethazine biogeochemical behavior and expression of resistance genes in the hyporheic zone: A case study of Chaobai river, China

It is well known that the intensive biogeochemical activity in hyporheic zone of groundwater and antibiotic contaminated river water induced the pollution diffusion and variation of biogeochemical transformation. However, the complex interaction process caused by water level fluctuation is difficult to accurately depict on a larger, catchment scale. Therefore, a loosely coupled HYDRUS-3D/GMS was e

”Se upp för nålen!” Intraoperativa stick- och skärskador bland operationssjuksköterskor: En enkätstudie

Bakgrund: Stick- och skärskador är vanligt bland operationspersonal. I samband med en stick- och skärskada startar en process som kan bli långdragen i form av oro i väntan på resultat och i värsta fall livslång sjukdom. Att uppmärksamma stick- och skärskador, vanliga moment när det sker och i vilken grad skadorna rapporteras är viktigt för att ett förbättringsarbete ska kunna planeras och implemen

The Formation and Breakdown of Passive Film on Ni Alloys : in situ synchrotron studies

Corrosion results in huge annual costs and a large environmental footprint. The corrosion rate of some alloys can be made negligible by the presence of a spontaneously forming oxide film on the surface, a so-called passive film. Famous examples of alloys exhibiting passivity are stainless steels. However, in some demanding applications, stainless steel does not provide significant corrosion resist

The negative association between serum free testosterone and leptin is dependent on insulin-like growth factor-binding protein 1 in healthy young and middle-aged men

OBJECTIVE: Previous studies have shown that serum levels of testosterone correlate negatively with leptin and positively with insulin-like growth factor binding protein 1 (IGFBP-1). The present study examined whether these associations are linked.DESIGN AND PATIENTS: The association between serum levels of IGFBP-1, free testosterone and insulin on one hand and leptin on the other hand were investi

Large-scale agile transformation in a manufacturing company : a knowledge-based view

Agile has been touted as a concept to deal with and succeed in the fast-paced environment in which companies operate today. Based on this concept, practitioners have created frameworks and practices that have proven to bring benefits in software development. Looking to extend these benefits beyond software development, companies are launching large-scale agile transformation initiatives, however,

Single-cell BCR and transcriptome analysis after influenza infection reveals spatiotemporal dynamics of antigen-specific B cells

B cell responses are critical for antiviral immunity. However, a comprehensive picture of antigen-specific B cell differentiation, clonal proliferation, and dynamics in different organs after infection is lacking. Here, by combining single-cell RNA and B cell receptor (BCR) sequencing of antigen-specific cells in lymph nodes, spleen, and lungs after influenza infection in mice, we identify several

Pitfalls in soft tissue cytopathology

Fine needle aspiration biopsy (FNAB) is a diagnostic modality for the evaluation of suspicious soft tissue masses. Despite its reasonable sensitivity, specificity and positive predictive value in differentiating benign from malignant neoplasms, the exact subtyping of the primary soft tissue tumours can be challenging. Certain tumours constitute “pitfalls” and add to the diagnostic challenge. This

Search for resonant and non-resonant Higgs boson pair production in the bb¯ τ+τ− decay channel using 13 TeV pp collision data from the ATLAS detector

A search for Higgs boson pair production in events with two b-jets and two τ-leptons is presented, using a proton–proton collision dataset with an integrated luminosity of 139 fb −1 collected at s = 13 TeV by the ATLAS experiment at the LHC. Higgs boson pairs produced non-resonantly or in the decay of a narrow scalar resonance in the mass range from 251 to 1600 GeV are targeted. Events in which at

Production of KS0 , Λ (Λ ¯), Ξ±, and Ω± in jets and in the underlying event in pp and p–Pb collisions

The production of strange hadrons (KS0 , Λ, Ξ±, and Ω±), baryon-to-meson ratios (Λ/ KS0 , Ξ/ KS0 , and Ω/ KS0), and baryon-to-baryon ratios (Ξ/Λ, Ω/Λ, and Ω/Ξ) associated with jets and the underlying event were measured as a function of transverse momentum (p T) in pp collisions at s = 13 TeV and p Pb collisions at sNN = 5.02 TeV with the ALICE detector at the LHC. The inclusive production of the