BACKGROUND: SGLT2 inhibitors and DPP4 inhibitors have been suggested to affect lipid metabolism. However, there are few randomized controlled trials comparing the effects on the lipid metabolism between the two types of antidiabetic drugs. The SUCRE study (UMIN ID: 000018084) was designed to compare the effects of ipragliflozin and sitagliptin on serum lipid and apolipoprotein profiles and other c

OBJECTIVE: Widespread use of immune checkpoint inhibitors (ICIs) in cancer treatment has led to an increase in the number of reported cases of immunotherapy-related endocrinopathies. This study aimed to analyze and compare human leukocyte antigen (HLA) signatures associated with ICI-induced type 1 diabetes (ICI-T1D) and isolated adrenocorticotropic hormone deficiency (ICI-IAD) in patients with bot

Increasing evidence suggests that Lewy body disease (LBD) is associated with clinically important cardiac complications, including sick sinus syndrome, atrial fibrillation and sudden cardiac death. The high prevalence of sick sinus syndrome and atrial fibrillation in LBD suggests the presence of disease-related atrial conduction disorders. To explore whether LBD is associated with atrial conductio

BACKGROUND AND AIM: This study aimed to clarify the efficacy and safety of 48-week pemafibrate treatment in patients with metabolic dysfunction-associated steatotic liver disease (MASLD) complicated by dyslipidemia.METHODS: A total of 110 patients diagnosed with MASLD complicated by dyslipidemia received pemafibrate at a dose of 0.1 mg twice daily for 48 weeks.RESULTS: The participants were 54 mal

AIMS: To evaluate the efficacy and safety of oral semaglutide for type 2 diabetes mellitus (T2DM) in patients with metabolic dysfunction-associated steatotic liver disease (MASLD).MATERIALS AND METHODS: This was a single-arm, multicentre, prospective study. Among 80 consecutive patients with MASLD and T2DM who newly received oral semaglutide, 70 completed 48-week oral semaglutide treatment as sche

Type 2 diabetes is associated with cardiovascular disease, possibly due to impaired vascular fibrous repair. Yet, the mechanisms are elusive. Here, we investigate alterations in the fibrous repair processes in type 2 diabetes atherosclerotic plaque extracellular matrix by combining multi-omics from the human Carotid Plaque Imaging Project cohort and functional studies. Plaques from type 2 diabetes

Non-islet cell tumor hypoglycemia (NICTH) is one of the paraneoplastic syndromes manifesting severe hypoglycemia caused by aberrant production of high-molecular-weight insulin-like growth factor 2 (big-IGF2). Two surgical cases of extremely large thoracic solitary fibrous tumors (SFT) with unusual history of NICTH are presented. One case manifested severe hypoglycemia after four years of the first

BACKGROUND: Tumor-produced high molecular weight insulin-like growth factor-II (big insulin-like growth factor-II) is considered to cause non-islet cell tumor hypoglycemia. This paper presents a case of surgically resected retroperitoneal liposarcoma that produced big insulin-like growth factor-II.CASE PRESENTATION: Here, we report the case of a 62-year-old woman who presented with an abdominal ma

BACKGROUND: Non-islet cell tumor hypoglycemia (NICTH) is a rare paraneoplastic syndrome caused by a tumor-producing high molecular weight form of insulin-like growth factor 2 (IGF2) known as big IGF2. The only curative treatment for this condition is surgical resection of the responsible tumors. However, this may not be feasible in cases with multiple metastases at diagnosis of NICTH, and no stand

Background: Middle Eastern (ME) immigrants to Europe have a heavy burden of metabolic disorders including a higher prevalence of insulin resistance, T2D and obesity as compared to native-born Europeans. Vitamin D insufficiency and deficiency are prevalent conditions in people originating from the ME. Aims: To study the differences in the levels of 25(OH)D and parathyroid hormone (PTH) across ME an

A novel pretreatment approach was developed in the present study to simultaneously reduce the content of inorganic troubling elements (TEs) and improve biomass energy density, i.e., combined leaching and steam explosion (SE) pretreatment with mechanical pressing. Three different high-ash-containing biomass feedstocks were studied – wheat straw (WS), spruce bark (SB), and empty fruit bunches of oil

Tertiary lymphoid structures (TLS) in the tumor microenvironment are prognostically beneficial in many solid cancer types. Reports on TLS in high-grade serous tubo-ovarian carcinoma (HGSC) are few, and the prognostic impact is unclear. We investigated mature TLS (mTLS), immature TLS (iTLS) and lymphoid aggregates (LA) in primary adnexal tumors (PTs) and synchronous omental/peritoneal metastases (p

Variants in GBA1 are important genetic risk factors in Parkinson's disease (PD). GBA1 T369M has been linked to an ∼80 % increased PD risk but the reports are conflicting and the relevance of GBA1 variants in different populations varies. A lack of association between T369M and PD in the Swedish population was recently reported but needs further validation. We therefore investigated T369M in 1,808

In my Ph. D. project, I study semantic change as it is described in the Swedish Acad-emy dictionary (SAOB). The starting point is five semantic labels that are established and highly frequent in the dictionary definitions, namely: bildlig (‘figurative’), oegent-lig (‘un-actual/non-factual’), överförd (‘transferred’), utvidgad (‘extended’) and all-männare användning (‘more general use’). These labe

Den gemensamma jordbrukspolitiken (CAP) reformeras regelbundet och arbetet pågår nu inför nästa programperiod som börjar 2028. En betydande del av jordbruksstöden utgörs av gårdsstöd, nötkreatursstöd, kompensationsstöd, omfördelningsstöd och ersättning till naturbetesmarker. Vi analyserar hur förändringar av nivåerna på dessa stöd skulle påverka jordbrukets produktion, konkurrenskraft och miljöpåv

Bakgrund - Ambulanssjukvården ska kunna bedriva triagering och avancerad sjukvård i det prehospitala rummet. Detta genom rätt kompetens och medicinteknisk utrustning. Riktlinjerna beskrivs som otillräckliga gentemot de patienter som inte bedöms vara kritiska. Ambulanssjuksköterskans bedömningsprocess beskrivs som olika faser som speglar arbetet före, under och efter mötet med patienten. Vårdande bBackground - In today's society, the ambulance services are expected to perform triage and advanced medical care in the prehospital environment. This is achieved through appropriate competence and medical-technical equipment. Guidelines are described as insufficient towards the patients that are not critically ill. The assessment process of the specialist ambulance nurse is described as comple

Bakgrund: Ambulanspersonal och akutvårdssjuksköterskor arbetar under pressande förhållanden, där de ofta utsätts för stressfaktorer som dödsfall, våld och traumatiska händelser. Studier visar att en stor del av ambulanspersonalen anser att deras arbete är psykiskt påfrestande, och problem som akut och kronisk stress, sömnsvårigheter och PTSD är vanliga bland dem. Det har blivit tydligt att detta a

This thesis examines the intersection of media engagement and the construction of national identity among the Yao people, an ethnic minority in China. This inquiry emerges against the backdrop of China's state-driven media narratives aimed at fostering national unity amidst its diverse ethnic landscape. The study investigates how the Yao people, with their rich cultural heritage and history of