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Background: Calcineurin inhibitors (CNIs) are associated with long-term complications after heart transplantation (HTx). Everolimus (EVR)-based immunosuppression allows for CNI withdrawal. We used data from The Scandinavian heart transplant everolimus de novo study with early CNI avoidance (SCHEDULE) trial to assess whether health-related quality of life (HRQoL) differed between patients on long-t

In recent years, remote sensing data have revealed considerable potential in unraveling crucial information regarding water balance dynamics due to their unique spatiotemporal distribution characteristics, thereby advancing multi-objective optimization algorithms in hydrological model parameter calibration. However, existing optimization frameworks based on the Soil and Water Assessment Tool (SWAT

In this work, we present results of numerical simulations of the formation and early evolution of rocky planets through pebble accretion, with an emphasis on hydrogen envelope longevity and the composition of the outgassed atmosphere. We modelled planets with a range in mass from 0.1 to 5 Earth masses that orbit between 0.7 and 1.7 AU. The composition of the outgassed atmosphere was calculated wit

Background: SepIVA has been reported to be an essential septation factor in Mycolicibacterium smegmatis and Mycobacterium tuberculosis. It is a coiled-coil protein with similarity to DivIVA, a protein necessary for polar growth in members of the phylum Actinomycetota. Orthologues of SepIVA are broadly distributed among actinomycetes, including in Streptomyces spp. Results: To clarify the role of S

Context. The Gaia-Sausage-Enceladus merger was a major event in the history of the Milky Way. Debris from this merger has been extensively studied with full kinematic data from the Gaia mission. Understanding the star formation history of the progenitor galaxy aids in our understanding of the evolution of the Milky Way and galaxy formation in general. Aims. We aimed to constrain the star formation

Background and aim: The popularity of remote and blended teachings in physiotherapy higher education is increasing. Initial evidence suggests that these methods are as effective as face-to-face teaching for theoretical and practical skill learning in physiotherapy; however, further research is required. Methods: This was a retrospective comparative study. Three groups of physiotherapy students und

Legislatures are a key institution in modern political systems. They control the executive: in parliamentary systems, they elect the government, and in presidential systems, they often approve the members of the cabinet who were appointed by the president. Moreover, legislatures and their committees are the main bodies in a political system in which new policies - in the form of law proposals - ar

CD59 is a cell-surface inhibitor of the terminal step in the complement cascade. However, in addition to its complement inhibitory function, a non-canonical role of CD59 in pancreatic beta cells has been identified. Two recently discovered intracellular alternative splice forms of CD59, IRIS-1 and IRIS-2, are involved in insulin exocytosis through interactions with SNARE-complex components. In mic

BACKGROUND: Participation in everyday life and personal recovery is often adversely affected for individuals with complex mental health needs. Flexible Assertive Community Treatment (FACT) is a recovery-oriented service targeting participation in everyday life and personal recovery and is thus important to understand from the perspectives of service users.AIM: To explore how service users experien

Micro-society experimental setups are increasingly used to infer aspects of human behavioural evolution. A key part of human society today is our dependence on, and use of, technology–whether simple (such as a knife) or complex (such as the technology that underpins AI). Previously, two groups of researchers used an abstracted-wheel experiment to explore the evolution of human technical behaviour,

Carbon capture and storage technologies (CCS) are being discussed and tested in different countries to reduce industrial emissions. Public opinion about industrial CCS (iCCS) can be a key factor in whether it will be implemented. Yet, measuring public acceptance of CCS is a challenge: on the one hand, the use of CCS is the subject of intense and controversial political debate. On the other hand, a

Decoherence of a charge qubit is usually credited to charge noise in the environment. Here we show that charge noise may not be the limiting factor for the qubit coherence. To this end, we study coherence properties of a crystal-phase defined semiconductor nanowire double quantum dot (DQD) charge qubit strongly coupled to a high-impedance resonator using radio-frequency reflectometry. Response of

Objectives To re-evaluate cut-offs for disease activity states according to the Axial Spondyloarthritis Disease Activity Score (ASDAS), and study the impact of sex, age, calendar time, disease and symptom duration on ASDAS and ASDAS cut-offs in a large contemporary cohort. Methods Data from 2939 patients with axial spondyloarthritis (axSpA) starting their first tumour necrosis factor inhibitor in

Cataract surgery is the most commonly performed surgery worldwide. However, there is significant variation in practice both within and among countries. The European Registry of Quality Outcomes for Cataract and Refractive Surgery was established in 2007 to address this variation and improve the quality of care. Based on registry data from more than 500,000 surgeries, the registry developed the fir

In conventional tomographic reconstruction, the pre-processing step includes flat-field correction, where each sample projection on the detector is divided by a reference image taken without the sample. When using coherent X-rays as a probe, this approach overlooks the phase component of the illumination field (probe), leading to artifacts in phase-retrieved projection images, which are then propa

Modeling of riverine dissolved organic carbon (DOC) dynamics is of great importance for the global carbon budget. Impoundment interception changes the travel time of water and DOC from upslope contributing areas, exerting substantial influence on riverine DOC dynamics in the catchments with many impoundments. However, the impact of impoundment interception representation on riverine DOC modeling h

I tidigare forskning inom strategisk kommunikation har klimatförändringar undersökts utifrån ett rationellt sätt att kommunicera olika politiska, företagsmässiga eller vetenskapliga intressen. Dessa studier förhåller sig ofta till känslor som antingen psykologiska effekter av planerad kommunikation eller som redan existerande faktorer vilka påverkar förståelsen av frågan. I dessa studier anses denPrevious research has studied the strategic communication of climate change as a rational and purposeful means of communicating about climate change in accordance with political, corporate or scientific interests. These studies often consider emotions either as the psychological effects of planned communication, or as pre-existing attachments that influence an individual's understanding of the iss

Measures to reduce the spread of COVID-19 have been associated with reduction in other respiratory infections. Results of a national Swedish cohort study of infant pertussis during April 2020–September 2021 were compared with those during January 2014–March 2020. The number of pertussis cases decreased significantly during the COVID-19 pandemic, from an average of 21 infant cases per quarter of a