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Molecular mechanisms and complete antigen formation in allergic contact dermatitis

Allergic contact dermatitis (ACD) is a common T cell mediated skin disease. Small reactive organic molecules called haptens induce ACD. Haptens are not recognized by themselves, but need to bond to endogenous proteins in the skin, and processed further into complete antigens. Antigen specific T cells then recognize the resulting antigen. Although the haptens are well known, the chemical reactions

Cost-effectiveness of maintenance treatment with a barrier-strengthening moisturizing cream in patients with atopic dermatitis in Finland, Norway and Sweden

Atopic dermatitis is a chronic skin disorder with high prevalence, especially in the Nordic countries. Effective maintenance therapy during symptom-free episodes may prolong the time to eczema relapse according to a previously published clinical trial. The present study evaluates the cost-effectiveness of a barrier-strengthening moisturizer containing 5% urea, compared with a moisturizer with no a

Patient-Specific Whole-Body Attenuation Correction Maps from a CT System for Conjugate-View-Based Activity Quantification: Method Development and Evaluation.

Abstract For activity quantification based on planar scintillation camera measurements, photon attenuation is an important factor that needs to be corrected for in a patient- and organ-specific manner. One possibility for obtaining attenuation correction maps is to use X-ray CT scout images. Since the intensity of scout images is in relative numbers, their image values need to be multiplied by a f

K to pi pi decays in SU(2) Chiral Perturbation Theory

We study the decays $K\to\pi\pi$ in one-loop two-flavour Chiral Perturbation Theory. We provide arguments why the calculation of the coefficient of the pionic chiral logarithm $\logm = M^2\log M^2$ is unique and then perform the calculation. As a check we perform the reduction of the known three-flavour result. Our result can be used to perform the extrapolation to the physical pion mass of direc

Molecular Characterization of Male Breast Cancer

Popular Abstract in Swedish Bröstcancer är den vanligaste cancerformen hos kvinnor i Sverige, men även män kan drabbas. Hos män är det dock en mycket ovanlig cancerform. I Sverige insjuknar cirka 40 män per år av bröstcancer jämfört med cirka 8000 kvinnor per år. Bröstcancer hos män och kvinnor är på många sätt lika. Till exempel är sjukdomstecknen desamma och visar sig oftast som en knöl eller knCancer is today a major healthcare problem worldwide. There are many forms of cancer, which is a genetic disease, believed to result from a multistep process with genetic and epigenetic changes accumulating over time. Breast cancer is one of the most common forms of cancer in women, while it is much more rare in men. Male breast cancer (MBC) exhibits both similarities and differences with female b

Environmental assessment of propionic acid produced in an agricultural biomass-based biorefinery system

This paper presents an environmental system study of the production of propionic acid in a biorefinery system based on agricultural by-products. Here, propionic acid is produced by fermentation of glycerol, a by-product from biodiesel production, as carbon source and potato juice, a by-product from starch production, as nitrogen source. Biomass-based propionic acid leads to a greenhouse gas reduct

Dissolution state of cellulose in aqueous systems. 1. Alkaline solvents

The understanding of the state of dissolution of cellulose in a certain solvent is a critical step forward in the development of new efficient solvent systems for cellulose. Nevertheless, obtaining such information is not trivial. Recently, polarization transfer solid-state NMR (PTssNMR) was shown to be a very promising technique regarding an efficient and robust characterization of the solution s

Measurement of the mass difference between top and anti-top quarks in pp collisions at root s=7 TeV using the ATLAS detector

A measurement of the mass difference between top and anti-top quarks is presented. In a 4.7 fb(-1) data sample of proton-proton collisions at root s = 7 TeV recorded with the ATLAS detector at the LHC, events consistent with t (t) over bar production and decay into a single charged lepton final state are reconstructed. For each event, the mass difference between the top and anti-top quark candidat

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Empowerment is a concept and a method in social work associated with liberation from oppression. Some paradoxes inherent in the concept and method of empowerment, however, lead to questioning the contradiction between freedom and force that is usually framed by “empowerment”. This dissertation investigates how empowerment is created in a concrete language and an integration project directed toward

A deepwater fish with 'lightsabers' - dorsal spine-associated luminescence in a counterilluminating lanternshark

We report the discovery of light organs (photophores) adjacent to the dorsal defensive spines of a small deep-sea lanternshark (Etmopterus spinax). Using a visual modeling based on in vivo luminescence recordings we show that this unusual light display would be detectable by the shark's potential predators from several meters away. We also demonstrate that the luminescence from the spine-associate

Flux analysis of the Lactobacillus reuteri propanediol-utilization pathway for production of 3-hydroxypropionaldehyde, 3-hydroxypropionic acid and 1,3-propanediol from glycerol

Background Lactobacillus reuteri converts glycerol to 3-hydroxypropionic acid (3HP) and 1,3-propanediol (1,3PDO) via 3-hydroxypropionaldehyde (3HPA) as an intermediate using enzymes encoded in its propanediol-utilization (pdu) operon. Since 3HP, 1,3PDO and 3HPA are important building blocks for the bio-based chemical industry, L. reuteri can be an attractive candidate for their production. However

An Overview of the Latest Graphene-Based Sensors for Glucose Detection: the Effects of Graphene Defects

In this review, we analyze several types of graphene-based sensors for glucose detection with respect to their preparation, properties and efficiency in electro-chemical processes. Graphene may display different types of defects, which play a role in the electron transfer processes. Oxygenated groups on the edges of graphene planes reduce the graphene in-plane conductivity, but may enhance the het

ADHD bör uppmärksammas mer - tidiga insatser spar lidande.

ADHD is a common neurodevelopmental/neuropsychiatric disorder affecting about 5 percent of children. About 2-3 percent meet diagnostic criteria in adulthood as well. The core symptoms include inattention with or without hyperactivity/restlessness and impulsivity. The main cognitive deficit involves executive functions, probably related to a weak reward system. Symptoms will affect daily functionin

Alcohol consumption and the risk for prostate cancer in the European prospective investigation into cancer and nutrition

Alcohol is a risk factor for several types of cancer. However, the results for prostate cancer have been inconsistent, with most studies showing no association. Within the European Prospective Investigation into Cancer and Nutrition, detailed information were collected from 142,607 male participants on the intake of alcoholic beverages at recruitment (for 100% of the cohort) and over lifetime (for

The effect of ambiguous risk, and coordination on farmers' adaptation to climate change - A framed field experiment

The risk of losses of income and productive means due to adverse weather can differ significantly among farmers sharing a productive landscape, and is of course hard to estimate, or even "guesstimate" empirically. Moreover, the costs associated with investments in reduced vulnerability to climatic events are likely to exhibit economies of scope. We explore the implications of these characteristics

Dynamics of charge separation in the excited-state chemistry of protochlorophyllide

In this study the excited-state dynamics of protochlorophyllide a (PChlide), the substrate of the enzyme protochlorophyllide oxidoreductase, was examined by means of time-resolved absorption anisotropy and magic-angle measurements. The solvent polarity dependent anisotropy data provide strong evidence for the existence of an excited-state with charge-transfer character. A solvent dependency is als