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Protein-protein interactions in AQP regulation - biophysical characterization of AQP0-CaM and AQP2-LIP5 complex formation

Protein-protein interactions play important roles in regulating human aquaporins (AQP) by gating as well as trafficking. While structural and functional studies have provided detailed knowledge of AQP transport mechanisms, selectivity as well as gating by conformational changes of loops or termini, the mechanism behind how protein-protein interactions control AQP-mediated water transport through c

Membrane processes in biorefineries: Opportunities and challenges to integrate membrane processes

Biorefineries are integrated biotech facilities aiming on full utilization of feedstock for the simultaneous production of e.g. food, biofuels and biochemicals. This presentation will provide an overview supported by case and application studies on the integration of membrane processes into biorefineries. Starting with the pre-treatment of the raw material e.g. wood biomass or starch, micro- (MF)

Draft Genome Sequence for the Tree Pathogen Phytophthora plurivora

Species from the genus Phytophthora are well represented among organisms causing serious diseases on trees. Phytophthora plurivora has been implicated in long-term decline of woodland trees across Europe. Here we present a draft genome sequence of P. plurivora, originally isolated from diseased European beech (Fagus sylvatica) in Malmö, Sweden. When compared with other sequenced Phytophthora speci

Use of flutemetamol F18-labeled positron emission tomography and other biomarkers to assess risk of clinical progression in patients with amnestic mild cognitive impairment

Importance: Patients with amnestic mild cognitive impairment (aMCI) may progress to clinical Alzheimer disease (AD), remain stable, or revert to normal. Earlier progression to AD among patients who were β-amyloid positive vs those who were β-amyloid negative has been previously observed. Current research now accepts that a combination of biomarkers could provide greater refinement in the assessmen

Plant functional trait change across a warming tundra biome

The tundra is warming more rapidly than any other biome on Earth, and the potential ramifications are far-reaching because of global feedback effects between vegetation and climate. A better understanding of how environmental factors shape plant structure and function is crucial for predicting the consequences of environmental change for ecosystem functioning. Here we explore the biome-wide relati

Search for supersymmetry in final states with charm jets and missing transverse momentum in 13 TeV pp collisions with the ATLAS detector

A search for supersymmetric partners of top quarks decaying as t˜1→cχ˜10 and supersymmetric partners of charm quarks decaying as c˜1→cχ˜10, where χ˜10 is the lightest neutralino, is presented. The search uses 36.1 fb−1pp collision data at a centre-of-mass energy of 13 TeV collected by the ATLAS experiment at the Large Hadron Collider and is performed in final states with jets identified as contain

Fermentation of dietary fibre components in the rat intestinal tract

1. The fermentative breakdown of dietary fibre from various sources in the intestinal tract was studied using rat balance experiments and gas-liquid chromatograhic analysis of dietary fibre monomers in feed and faces. 2. On a basal diet with 690 g maize starch/kg but no added fibre, small but detectable amounts of polymeric glucose, rhamnose, arabinose, xylose, galactose, mannose and uronic acids,

Bulk laxatives : their dietary fibre composition, degradation, and faecal bulking capacity in the rat

The intestinal dietary fibre degradation and faecal bulking capacity of various bulk laxatives were investigated by means of balance experiments on rats. Nitrogen, fat, and mineral excretion in faeces was also studied. The dietary fibre content of the various bulk laxatives was quite different (in g/kg dry matter): ACO fibre tablets (barley and citrus pulp), 451; Fiberform (wheat bran-based), 817;

Determination of digestible energy values and fermentabilities of dietary fibre supplements : a European interlaboratory study in vivo

The performance of methods to determine energy conversion factors for dietary fibre (DF) supplements and fermentability (D) values of their non-starch polysaccharides (NSP) was investigated. Heats of combustion, digestible energy (DE) and D values were determined on five DF supplements in five European laboratories on five separate occasions. In each instance the DF supplements were fed to juvenil

Survival of Lactobacillus plantarum DSM 9843 (299v), and effect on the short-chain fatty acid content of faeces after ingestion of a rose-hip drink with fermented oats

In a controlled and randomised double-blind study, 26 healthy adult volunteers consumed, for 21 d, 400 ml of a rose-hip drink containing oats (0.7 g/100ml) fermented with Lactobacillus plantarum DSM 9843 (RHL; containing 5 x 10(7) cfu ml(-1)), and 22 volunteers in a second group the same amount of a pure rose-hip drink (RH). Significant increases in the total faecal concentration of carboxylic aci

Dose-response effects of boiled carrots and effects of carrots in lactic acid in mixed meals on glycaemic response and satiety

Objective: To evaluate the effect of dosage on the metabolic response to vegetables added to a mixed lunch meal, and to relate the amounts to the tripartite plate model. Carrots were chosen as an example, and the carrots were blanched, frozen and boiled to include possible effects of processing and cooking. The effects of carrots steeped in lactic acid, as produced at fermentation, were also studi

Binding of mineral elements by dietary fibre components in cereals-In vitro (III)

The ability of soluble fibre fractions isolated from three different cereals (barley flour, whole grain rye flour and oat bran) to bind copper(II), cadmium(II) and zinc(II) ions has been studied using a potentiometric method. Considerable association was found between all fibre fractions and metals investigated. The ability of the metal ions to form complexes was found to be in the order Cu(II) >

Degradation of water-soluble fibre polysaccharides in carrots after different types of processing

The molecular weight distribution and the viscosity of water-soluble polysaccharides isolated from carrots were investigated after different types of heat-treatment, commonly used when preparing food. The materials studied were blanched, boiled, microwaved and canned. Freezing, without any heat-treatment, was used as a reference process. The water soluble polysaccharides were isolated using two di

Binding of mineral elements by some dietary fibre components-In vitro (II)

The ability of some fibre preparations (soluble fibre fractions of wheat bran and whole-grain wheat bread-dough, a bulk-laxative-Inolaxol-and cellulose) to bind copper (II), zinc(II) and cadmium(II) ions has been studied using a potentiometric method. Soluble fibre fractions of wheat bran and whole-grain wheat bread-dough, in which most of the phytate was present, interacted strongly with the meta