This thesis consists of four papers. In the first paper, we study the isotonic regression estimator over a general countable preordered set. We obtain the limiting distribution of the estimator and study its properties. Also, it is shown that the isotonisation preserves the rate of convergence of the underlying estimator. We apply these results to the problems of estimation of a bimonotone regress

Research has shown that bicycling is a marginalised mode of transport in Sweden, especially in Sweden’s capital city Stockholm. This leads to the question, why that might be the case. Koglin and Rye (2014) have already touched upon the issue of space when it comes to the marginalisation of cycling. In this paper I analyse the impact of the spatial dimension further and connect the spatial dimensio

The 16th ERS Lung Science Conference (LSC) took place on March 8–11, 2018, in Estoril, Portugal, with around 200 delegates from all over the world. This year’s topic was “Cell-matrix interactions in lung disease and regeneration” and involved excellent presentations by leading experts in the field covering everything from exploratory studies on how the matrix functions, matrix remodelling and biom

The Court of Justice’s role in controlling the exercise of Union legislative powers is a longstanding topic in EU legal scholarship. Observers have criticised the Court’s accommodating approach to the EU legislator’s broad interpretation of its powers and contended that the Court cannot be trusted to enforce the distribution of competences between the Union and the Member States (the ‘federal dime

Adult Education and the Formation of Citizens turns attention towards normative claims about who adults should become through education, and what capacities and skills adults need to develop to become included in society as ‘full’ citizens. Through these debates, adults are construed as not yet citizens, despite already being citizens in a formal sense; this book problematises such regimes of trut

Science has become a central political concern with massive increases in public investments and expectations, but resources are embedded in a complex web of societal expectations, which vary between countries and regions. This book outlines an insightful understanding of science policy as both concerning the governance of science itself (priority-setting, funding, organization and articulation wit

Pursuant to the precepts of EU law, EU policy-makers are bound to ensure that any EU legislation must fall within the remit of the EU's competences. This monograph looks at this highly contested issue, with particular reference to European Union criminal law. It looks at the powers enjoyed by the EU to impose criminal sanctions to suggest mechanisms by which legislative powers could be kept in che

This article analyse the scope of the Union’s regulatory criminal law competence subsequent to the ratification of the Lisbon Treaty. The article is primarily focused on examining what legal limitations that can be imposed on the Union’s competence to impose criminal penalties under the new legal basis in Article 83(2) TFEU. In particular, the article examines in detail whether criminal sanctions

In the year of 2000, the ECJ delivered a well-known judgement among European lawyers, Angonese, which indeed recognised horizontal direct effect of community law among private parties in the field of free movement of workers. The ECJ thus held that a job applicant could sue a private bank before the national court on the basis of the prohibition of discrimination in Article 39 of the EC Treaty. Co

Increased tissue stiffness is a classic characteristic of solid tumors. One of the major contributing factors is increased density of collagen fibers in the extracellular matrix (ECM). Here, we investigate how cancer cells biomechanically interact with and respond to the stiffness of the ECM. Probing the adaptability of cancer cells to altered ECM stiffness using optical tweezers based micro-rheol

Background: Individuals with knee and hip osteoarthritis (OA) are less physically active than people in general, and many of these individuals have adopted a sedentary lifestyle. In this study we evaluate the outcome of education and supervised exercise on the level of physical activity in individuals with knee or hip OA. We also evaluate the effect on pain, quality of life and self-efficacy. Meth

Aims: This study investigates the lobbying actors of the food and drink industry (FDI), their web lobbying arguments used in the sugar taxation debate and the tactics deployed when facing legislative restrictions on their products to curb the burden of non-communicable diseases in Europe. Methods: A stakeholder analysis was performed to identify the FDI’s actors lobbying against sugar taxation wit

Objectives We examined whether daily physical activity (PA) during compulsory school encourages children to be more physically active during the intervention and 4 years after termination of the programme. Methods This prospective controlled intervention study followed the same 124 children (81 children in an intervention group and 43 controls) aged 7.7±0.6 (mean±SD) during a 7-year PA interventio