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On integral equation methods for the first Dirichlet problem of the biharmonic and modified biharmonic equations in nonsmooth domains

Despite important applications in unsteady Stokes flow, a Fredholm second kind integral equation formulation modeling the first Dirichlet problem of the modified biharmonic equation in the plane has been derived only recently. Furthermore, this formulation becomes very ill-conditioned when the boundary is not smooth, say, having corners. The present work demonstrates numerically that a method call

Drivers of innovation productivity of academic researchers through career advancement

This paper studies the innovation productivity of academic researchers across their career advancement. Taking patents and invention disclosures as indicators of innovation productivity and using survey data from a large German public research organization, researchers’ productivity is examined during early career and early to mid-career across various dimensions, including years since employment,

Implementation of evidence-based interventions : analyzing critical components for sustainability in community mental health services

This study analyses the implementation and sustainability of evidence-based community mental health services in the form of publicly financed Individual Placement and Support programs. Critical implementation components and program fidelity were assessed after one year. After two years, program fidelity was assessed once again. After three years, the programs’ sustainability was assessed and semi-

Differences in Perception of Extended Producer Responsibility and Product Stewardship among Stakeholders : An International Questionnaire Survey and Statistical Analysis

Different perceptions of the concept of extended producer responsibility and product stewardship (EPR/PS) have tended to lead to prolonged policy disputes and have likely affected the design of EPR/PS policies. We therefore surveyed stakeholders’ perceptions of the concept of EPR/PS, including its aims, application, and rationales, and analyzed 376 responses with regression analysis and cluster an

Updated European Association of Urology Guidelines for Cytoreductive Nephrectomy in Patients with Synchronous Metastatic Clear-cell Renal Cell Carcinoma

Cytoreductive nephrectomy (CN) has been the standard of care in patients with metastatic clear-cell renal cancer who present with the tumour in place. The CARMENA trial compared systemic therapy alone with CN followed by systemic therapy. This article outlines the new guidelines based on these data. Patient summary: The CARMENA trial demonstrates that immediate cytoreductive nephrectomy should no

Hasteners and delayers: why rains don't cause fires

We typically judge that hasteners are causes of what they hasten, while delayers are not causes of what they delay. These judgements, I suggest, are sensitive to an underlying metaphysical distinction. To see this, we need to pay attention to a relation that I call positive security-dependence, where an event E security-depends positively on an earlier event C just in case E could more easily have

Second primary cancers in non-Hodgkin lymphoma : Bidirectional analyses suggesting role for immune dysfunction

Second primary cancers (SPCs) account for an increasing proportion of all cancer diagnoses. It is unlikely that prior therapy is solely responsible for SPC risk. To investigate risk of SPC after diagnosis of non-Hodgkin lymphoma (NHL) and 10 of its subtypes we conducted a novel bidirectional analysis, SPCs after NHL and NHL as SPC. Using the Swedish Family-Cancer Database, we identified 19,833 ind

Sediments of MIS 5e age suggested by new OSL dates from the Skilvika section, west Svalbard

The sediment succession at Skilvika, west Svalbard, represents one of the key stratigraphic records of the Late Quaternary palaeoenvironments and glaciation history of the Svalbard/Barents Sea area. A formation of raised marine sediments, interfingering with and capped by glacial deposits of local origin, have previously been assumed to be of an Early Weichselian age, likely marine isotope stage (

Baseline visual acuity as a prognostic factor for visual outcomes in patients treated with aflibercept for wet age-related macular degeneration : data from the INSIGHT study using the Swedish Macula Register

Purpose: To assess mean change in visual acuity (VA) overall and stratified by baseline VA after 1 and 2 years’ treatment with aflibercept in a real-life setting. Methods: This was an observational cohort study using nationwide data from the Swedish Macula Register. Treatment-naïve patient eyes with wet age-related macular degeneration and prescribed aflibercept from January 2013 to December 2014

Altered metabolism distinguishes high-risk from stable carotid atherosclerotic plaques

Aims: Identification and treatment of the rupture prone atherosclerotic plaque remains a challenge for reducing the burden of cardiovascular disease. The interconnection of metabolic and inflammatory processes in rupture prone plaques is poorly understood. Herein, we investigate associations between metabolite profiles, inflammatory mediators and vulnerability in carotid atherosclerotic plaques.Me

Use of Vascular Assessments and Novel Biomarkers to Predict Cardiovascular Events in Type 2 Diabetes : The SUMMIT VIP Study

OBJECTIVE: Cardiovascular disease (CVD) risk prediction represents an increasing clinical challenge in the treatment of diabetes. We used a panel of vascular imaging, functional assessments, and biomarkers reflecting different disease mechanisms to identify clinically useful markers of risk for cardiovascular (CV) events in subjects with type 2 diabetes (T2D) with or without manifest CVD.RESEARCH

Developing and sustaining new regional industrial paths : investigating the role of ‘outsiders’ and factors shaping long-term trajectories

This article casts light on the development of new regional industrial paths. We explore factors explaining why regional industries with similar early path development trajectories may exhibit diverging outcomes in the longer run and pay particular attention to the role of ‘outsiders’ in the initiation and further development of regional industrial paths. Drawing on a comparative case study of IT

Favorable effect of mycorrhizae on biomass production efficiency exceeds their carbon cost in a fertilization experiment

Biomass production efficiency (BPE), the ratio of biomass production to photosynthesis, varies greatly among ecosystems and typically increases with increasing nutrient availability. Reduced carbon partitioning to mycorrhizal fungi (i.e., per unit photosynthesis) is the hypothesized underlying mechanism, as mycorrhizal abundance and plant dependence on these symbionts typically decrease with incre

Human Neural Stem Cells for Ischemic Stroke Treatment

Ischemic stroke is the second most common cause of death worldwide and a major cause of disability. It takes place when the brain does not receive sufficient blood supply due to the blood clot in the vessels or narrowing of vessels’ inner space due to accumulation of fat products. Apart from thrombolysis (dissolving of blood clot) and thrombectomy (surgical removal of blood clot or widening of ves

Living in Two Worlds – Children's Experiences After Their Parents' Divorce – A Qualitative Study

Purpose: The aim of this study was to gain a deeper understanding of how children living in two homes after parents' separation experience their everyday lives. Design and Methods: An inductive qualitative design was chosen for the study using a hermeneutic phenomenological approach. Twelve children aged 10–13 years, and living in two homes, were interviewed. The data analysis used the four fundam

Criteria for ECG detection of acute myocardial ischemia : Sensitivity versus specificity

Background: Criteria for electrocardiographic detection of acute myocardial ischemia recommended by the Consensus Document of ESC/ACCF/AHA/WHF consist of two parts: The ST elevation myocardial infarction (STEMI) criteria based on ST elevation (ST↑) in 10 pairs of contiguous leads and the other on ST depression (ST↓) in the same 10 contiguous pairs. Our aim was to assess sensitivity (SE) and specif