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High-throughput screening is one of the most extensively used methods for the identification of molecules of interest during early stages of drug development projects. It is however subject to many artifacts due to various mechanisms. Aggregation and redox cycling are examples of mechanisms of unspecific inhibition that make a large number of compounds appear as active in several high throughput s
Framställningen syftar till att undersöka hur HD:s tolkning av kommersiella entreprenadavtal utvecklats. För att uppnå syftet utreds hur entreprenadavtal ska tolkas, hur praxis har utvecklats på området sedan år 2000 samt vilka konsekvenser utvecklingen kan medföra. Entreprenadavtal är inte lagreglerade i svensk rätt och sparsamt behandlade i doktrin. Termen kan förstås som ett avtal där entrepreThe purpose of the thesis is to examine how the interpretation of construction contracts has evolved by the Supreme Court. The thesis examines how the contracts should be interpreted, how the precedents have developed in the field since year 2000 and what consequences the development could bring. Construction contracts are not regulated by Swedish law and are rarely treated in the doctrine. A con
The theme for this analysis comes directly as an assignment from Svensk Elitfotboll (SEF) with the purpose to analyze and compare violence crime rate between high risk football matches and festivals. The reason for this is that SEF has come to believe that football matches tend to be described as more dangerous to the public than festivals and therefore giving the whole experience of going to see
En av de mest centrala författningarna på förmögenhetsrättens område är den svenska avtalslagen. Lagen tillkom genom ett juridisk samarbete mellan de nordiska länderna. Den antogs 1915 i Sverige, och därefter även i de övriga nordiska länderna. Då lagen nu uppnått en hög ålder väcks frågan om den behöver reformeras, eller om den än idag fungerar väl i det moderna samhället. Den här uppsatsen syftaOne of the most central acts on commercial matters in Sweden is the Swedish Contract Act. The act was created through a legal cooperation between the Nordic countries. It was adopted in 1915 in Sweden, and afterwards in the other Nordic countries. As the act now has reached an advanced age, the question arises if there is a need for a reformation, or if it still works well in the modern society. T
Internet har inneburit en förändring ur många många aspekter. Tekniken har medfört förändringar för hur vi kommunicerar, samlar in och delar med oss information och material m.m. Denna utveckling har medfört ett flertal intressekonflikter. Det kan handla om att skyddat material, till exempel upphovsrättsskyddad musik, kan spridas utan rättighetsinnehavarens medgivande eller att personuppgifter ellInternet has resulted in changes in many aspects. The technology has brought changes in how we communicate, retrieve and share information and material etc. This development has resulted in several conflicts of interests, that encompass protected material such as copyrighted music that can be shared without the consent of the copyright owner or that private information about an individual is circu
In the last decades one of the main topics in the international intellectual property forum has been the biopiracy issue. Genetic resources and traditional knowledge from developing nations are being misappropriated (i.e. biopiracy), by commercial actors in order to receive patent protection. Developments in genetics and biotechnology have intensified the controversy and attempts were initially so
Sammanfattning Det är ett vanligt fenomen att webbplatser använder sig av cookies för att samla in information, vilken sedan säljs vidare till tredje part i marknadsföringssyfte. Denna teknik fungerar oberoende den fysiska personens geografiska placering i världen. Förfarandet väcker frågor om personlig integritet och individens möjligheter till skydd i ljuset av teknikutvecklingen. FramställningeIt is a common phenomenon that websites use cookies in order to collect information, which thereafter is being sold to a third party for marketing purposes. This technique works regardless of the natural person's geographical location in the world. The process raises issues in relation to privacy protection and the individual's protection in light of the technological development. The purp
Lagen (1915:218) om avtal och andra rättshandlingar på förmögenhetsrättens område, AvtL och Internationella köplagen eller United Nations Convention on Contracts for the International Sale of Goods, CISG, innehåller båda bestämmelser om ingående av avtal som bygger på en anbud-acceptmodell. Även om båda regelverken har samma grundstruktur, skiljer de sig åt i några avseenden, särskilt ifråga om möLagen (1915:218) om avtal och andra rättshandlingar på förmögenhetsrättens område, AvtL, and the United Nations Convention on Contracts for the International Sale of Goods, CISG, both contain provisions on the conclusion of contracts based on an offer-acceptance model. Although both legal systems have the same basic structure, they differ in some aspects, especially regarding the possibility to re
Entreprenadprojekt karakteriseras av att vara komplicerade projekt förbundna med stora ekonomiska risker. Avsaknaden av entreprenadrättslig lagreglering har fått marknadens parter att förhandla fram standardavtal för entreprenader: AB 04 i Sverige och dess norska motsvarighet NS 8405. AB 04 bär prägel av att vara en kompromisslösning, vilket märks särskilt tydligt i dess felansvarsregler. Uppsatse
Skåne kan ha dubbelt så höga utsläpp av växthusgaser. Ett nytt examensarbete visar att länet har mycket högre utsläpp än tidigare rapporterat. Beroende på hur man räknar verkar utsläppen dessutom inte minskat som man tidigare har rapporterat. Det kan finnas en risk att rapporterade utsläppen sjunker medan de indirekta utsläppen som inte rapporteras istället ökar. Denna risk bygger på att vi säljeThis report will analyse an emission monitoring strategy for Skåne in Sweden, as anthropogenic global warming will have a significant environmental impact on the society. Sweden has a great potential for lowering greenhouse gas emissions as a nation. The monitoring of greenhouse emissions within Sweden shows that the trend is slowly coming down. However, new methodologies of monitoring show that c
Samhället i stort drar nytta av teknologisk utveckling; kanske underlättar den vår vardag, gör att samhället kan spara resurser eller gör viktig utrustning snabbare och noggrannare. En av de moderna grenarna av teknologi kallas nanoteknologi och innefattar konstruktion och tillämpning av strukturer på nanometernivå, det vill säga mycket små saker. Till exempel är så kallade nanotrådar, som detta pThe study of electronic transport in chemically synthesized semiconductor nanowires is an active field of research, with potential applications in areas such as quantum computing and nanoelectronics. Motivated by recent experimental progress, we use a simple non-atomistic tight-binding model implemented in open-source software to simulate quantum electronic transport in such nanowires. Including v
The Amazon Rainforest is in grave danger of disappearing for good, due to a number of harmful economic activities, including land conversion for cattle ranching and monoculture, as well as unsustainable and illegal timber production. It has been shown, however, that the private sector has a crucial role in redressing socio-economic problems, causing deforestation and degradation. To illustrate thi
The purpose of this study was to examine how the school welfare officers practice and think of the obligation to report child maltreatment and neglect to the social services according to the Swedish Social Service Law. The aim of the study was also to examine how the school welfare officere view upon the cooperate with other school staff and with the social workers at the social services due to th
Abstract: The 17th century philosopher Spinoza is known for his concept of God as One Substance, God or Nature and therefore considered as a monist and categorized as a naturalist. He has been labeled an atheist and God-intoxicated man, as well as a determinist and pantheist, which I perceive to be dichotomies. The problem, as I see it, is that Spinoza’s philosophy and concept of God has mainly be
The Philosophy of Mind, which pertains to the study of mental properties and physical properties in relation to the world, has been around since the 4th century with philosophers like Socrates and Plato. The Mind and Matter Problem, also known as the Body and Soul Problem, deals with the issues of identifying and understanding the apparent difference between the mental mind or soul and the physica
The aim of this thesis is to study the flammability and fire spread for textile membranes for weather protection. This thesis includes literature studies to determine current standards and recommendations available. Main focus however have been on the European classification system EN 13501-1 and construction site safety. Two types of experimental tests have been done, cone calorimeter test and te
Denna uppsats undersöker möjligheten att modellera fyra svenska oreglerade älvars vattenföring mellan 1980-2015 med hjälp av ARMA-, GARCH- och SETAR-modeller. Genom att studera den mängd vatten som transporteras i vattendrag och hur dess beroendestruktur ser ut i allmänhet kan förståelse om bland annat djurliv och klimateffekter fördjupas. Tidsseriens process behandlas som ett additivt system där This paper studies the possibility to model the water flows of four Swedish unregulated rivers between 1980-2015 with ARMA, GARCH and SETAR models. By examining the amount of water that flows through the river and what the dependence in the process looks like in general, a further understanding for effects on for example wildlife and climate changes can be developed. The process of the time series
Thermal comfort in highly glazed buildings has long proven to be a troublesome matter due to unwanted passive solar heat gains. Excessive solar gains are commonly counteracted with energy-intensive cooling systems and/or comprehensive shading devices. Shading devices are used to adjust solar heat transmission through glazing. Conventional devices may be protruding such as lamellas and overhangs o
Toyota Motor Company förändrade världen med sitt produktionssystem. Genom att ta bort aktiviteter som inte adderade värde till produkten, kunde företaget bli agilt med korta ledtider till kunden och till en låg produktionskostnad. För att bli konkurrenskraftiga tvingades företag världen över förändra sina produktionsprocesser och en västlig variant av Toyotas produktionsfilosofi uppstod. Denna varToyota Motor Company changed the world with their production system. By removing activities in the manufacturing process that were not adding any value to the product, the company could become agile and offer products to the customer with short lead time as well as to a low cost. Companies in other countries needed to change their manufacturing processes in order stay competitive and a western var
Even though protonemal development of bryophytes has been well studied, it remains unknown whether interspecific competition among mosses species affects their early growth and development. This study evaluated the effects of interspecific competition on in vitro germination and gametophyte development between each pair-wise combination from six common moss species: Atrichum undulatum, Bryum argen
