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Tasquinimod (a quinoline-3-carboxyamide) is a small molecule immunotherapy with demonstrated effects on the tumor microenvironment (TME) involving immunomodulation, anti-angiogenesis and inhibition of metastasis. A target molecule of tasquinimod is the inflammatory protein S100A9 which has been shown to affect the accumulation and function of suppressive myeloid cell subsets in tumors. Given the m

Recension av Bengt Gustafsson; Sanningen om ubåtsfrågan. Ett försök till analys.

Climate policy is a relatively young and dynamic area of public policy making. However, its development has attracted far more attention than the results it delivers in practice, which of course are the concern of policy evaluators. This article attempts to provide the first systematic cataloging of the emerging patterns of policy evaluation undertaken in different parts of the European Union. The

This review encompasses the most important advances in liver functions and hepatotoxicity and analyzes which mechanisms can be studied in vitro. In a complex architecture of nested, zonated lobules, the liver consists of approximately 80 % hepatocytes and 20 % non-parenchymal cells, the latter being involved in a secondary phase that may dramatically aggravate the initial damage. Hepatotoxicity, a

The jet energy scale and its systematic uncertainty are determined for jets measured with the ATLAS detector at the LHC in proton-proton collision data at a centre-of-mass energy of root s = 7 TeV corresponding to an integrated luminosity of 38 pb(-1). Jets are reconstructed with the anti-k(t) algorithm with distance parameters R = 0.4 or R = 0.6. Jet energy and angle corrections are determined fr

Seismic isolation is a strategy to reduce damage of structures exposed to devastating earthquake excitations. Isolation systems, applied at the base of buildings, lower the fundamental frequency of the structure below the range of dominant frequencies of the ground motion as well as allow to dissipate more energy during structural vibrations. The effectiveness of the base-isolated buildings in dam

Caveolae and lipid rafts are plasma membrane microdomains that are considered to play a role in cellular signalling. Caveolins and cavins as well as cholesterol are required for the structure and function of caveolae. The papers summarized in this thesis examine the role of caveolae in smooth muscle function. Ca2+-sensitization is a contractile process depending on inhibition of myosin phosphatase

This article focuses on the Swedish middle distance runner Gunder Hägg (1918–2004). The peak of his career coincided with WWII, and in the Summer of 1942 he broke 10 out of his 15 world records. The year after, he made a much appreciated and successful running tour to the US. This made Hägg the first real media sports star in Sweden. The article analyses the representation of Hägg in different med

There is a paucity of diagnostic instruments for adults with autism spectrum disorder (ASD). This study evaluates the psychometric properties of the Swedish version of the Ritvo Autism and Asperger Diagnostic Scale-Revised (RAADS-R), an 80-item self-rating scale designed to assist clinicians diagnosing ASD in adults. It was administered to 75 adults with ASD and 197 comparison cases. Also, a subse

Pathogenic microbes acquire human complement inhibitors to circumvent the innate immune system. In this study, we identify two novel host-pathogen interactions, factor H (FH) and factor H-like protein 1 (FHL-1), the inhibitors of the alternative pathway that binds to Hib. A collection of clinical Haemophilus influenzae isolates was tested and the majority of encapsulated and unencapsulated bound F

Graphics processing units supporting tessellation of curved surfaces with displacement mapping exist today. Still, to our knowledge, culling only occurs after tessellation, that is, after the base primitives have been tessellated into triangles. We introduce an algorithm for automatically computing tight positional and normal bounds on the fly for a base primitive. These bounds are derived from an

A two-dimensional numerical model of nearshore waves, currents, and sediment transport was developed. The multi-directional random wave transformation model formulated by Mase [Mase, H., 2001. Multidirectional random wave transformation model based on energy balance equation. Coastal Engineering Jounnal 43(4), 317-337.] based on an energy balance equation was employed with an improved description

The majority of motorcycle accident fatalities in Malaysia occur on primary roads, especially at access points situated along straight road sections. To explore the behavioral factors that may contribute to motorcyclists being involved in hazardous situations at these locations and to develop working hypotheses for a consecutive quantitative study, a qualitative observational study was carried out

Recently, the performance of many-light algorithms, where thousands of light sources are used to compute the lighting in a scene, has improved so much that they have reached the realm of real-time rendering. In general, the algorithm that is considered “best” is the one that is the fastest in terms of time per frame. Given that power efficiency may become or already is one of the most important op

Pollen accumulation rates (PARs) provide a potential proxy for quantitative tree volume (m3 ha-1) reconstruction with reliable absolute pollen productivity estimates (APPEs). We obtained APPEs for pine, spruce and birch at their range limits in northern Finland under two temperature periods (warm and cold) based on long-term pollen trap and tree volume records within a 14-km radius of each trap. A

Drying of screeded floor slabs is an important issue for the building industry. However, virtually no attention is paid in prediction models to the hysteresis of sorption isotherms, mainly because of lack of data. Disregarding the hysteresis in prediction models will generate inaccurate predictions of future moisture distribution and remaining drying time. This paper presents a method for fast det

Selected reaction monitoring mass spectrometry (SRM-MS) is a targeted proteomics technology used to identify and quantify proteins with high sensitivity, specificity and high reproducibility. Execution of SRM-MS relies on protein-specific SRM assays, a set of experimental parameters that requires considerable effort to develop. Here we present a proteome-wide SRM assay repository for the gram-posi

Symptoms of fecal incontinence and constipation are common in the general population. These can, however, be unreliably reported and are poorly discriminatory for underlying pathophysiology. Furthermore, both symptoms may coexist. In the elderly, fecal impaction always must be excluded. For patients with constipation, colon transit studies, anorectal manometry and defecography may help to identify

A small assemblage of shelly fossils, dominated by the brachiopod Treptotreta jucunda and the bradoriid arthropod Mongolitubulus aspermachaera new species is described from a Furongian limestone of Vastergotland, south-central Sweden. Mongolitubulus aspermachaera is represented in the assemblage by individual valves and numerous, ornamented spines. Valves and spines share identical ornament and mi