In order to identify agonist- and antagonist-binding epitopes in the human B1 and B2 bradykinin (BK) receptors, we exploited the ability of these receptors to discriminate between peptide ligands that differ only by the absence (B1) grid presence (B2) of a C-terminal Arg. This was done by constructing chimeric proteins in which specific domains were exchanged between these receptors as recently de

The B1 and B2 bradykinin (BK) receptor subtypes belong to the GPCR faro ily, and they discriminate between peptides that differ only by the absence and presence of a C-terminal Arg, To identify receptor residues conferring tigand spe.cificity, chimeric constructs in which TM-III were exchanged between the receptors were expressed and assayed by radioligand binding and fluorescence Ca2+ imaging in

Artificiell intelligens bryter med invanda sätt att tänka kring å ena sidan objekt, ting, teknologiska artefakter och, å andra sidan, handlande subjekt. Somliga tänker rent av på artificiell intelligens som en ny form av liv. En sfär där artificiell intelligens står inför ett genombrott är i krig. Av förklarliga skäl finns starka åsikter om detta. Utvecklingen förkastas som innebärandes slutet på

The present paper investigates the ongoing validity of the notion of subordination as selection criteria to allocate the labour protections in the contemporary economic framework. The gig economy is deeply affecting the way of working, transforming the employee in a service provider. This phenomenon is partially due to the progressive shift from a firm-based production model towards a market trans

In altricial birds, the period of parental investment covers three distinctly separated phases: Incubation, feeding of nestlings, and feeding of fledglings in the family group. The transition between the latter two phases occurs when the brood fledges and leaves the nest. To investigate which party, parents or offspring, initiates nest leaving, different-aged broods were swopped between nestboxes

Duplicate, bilateral structures of individual animals are usually symmetrical. In cases where such structures are asymmetrical, the degree of asymmetry may indicate the propensity of an individual to stray from the genetically programmed outcome during the development of the structure. Asymmetries have recently been assumed to constitute an honest signal of male quality and, as such, a cue for fem

Breast cancer is the most common cancer among women in the Western world. In Sweden, 1 in 9 women will be diagnosed during their lifetime, amounting to >8,000 new breast cancers per year. Each year around 1,400 patients die from their disease. A comprehensive report entitled "highlighted several areas in need of more research", including how weight, alcohol consumption, smoking, host metabolism an

In an aviary study, each of six male European Nuthatches Sitta europaea was allowed to hoard 30 sunflower seeds in natural hoarding substrates. After eight days, each bird was allowed to search for its cached seeds and its performance compared with that of a bird without previous experience of the specific aviary. In all but one case, the hoarder found significantly more seeds than did the naive b

Living in a complex and dynamically changing environment requires accurate and timely behavioural responses that allow for adapting to such changes. Well-developed perceptual systems provide a continuous flow of abundant and up-to-date information on the changes in the environment, and, thereby, allow for tailoring behavioural responses accordingly. However, issuing any behavioral response would n

Topical application of capsaicin is thought to deplete substance P from local sensory nerve terminals. In experiments on human skin inflammation was induced by injection of substance P (SP) or histamine intradermally, UV irradiation, non-immunologic contact urticaria, tuberculin reaction, contact allergens and benzalkonium chloride with or without capsaicin pretreatment. The flare response to SP a

In this paper, the role and significance of opinion-shaping and persuasion activities are explored through an analysis of the activation of women in the Swedish labour market in the 1960s, highlighting the ways in which gender equality ideals became infused in these activities through a process of ‘transformative state feminism’. The analysis draws on qualitative data including archival material aIn this paper, the role and significance of opinion-shaping and persuasion activities are explored through an analysis of the activation of women in the Swedish labour market in the 1960s, highlighting the ways in which gender equality ideals became infused in these activities through a process of ‘transformative state feminism’. The analysis draws on qualitative data including archival material a

Calcium activation of the C-terminal domain of calmodulin was studied using 1H and 15N NMR spectroscopy. The important role played by the conserved bidentate glutmate Ca2+ ligand in the binding loops is emphasized by the striking effects resulting from a mutation of this glutantic acid to a glutamine, i.e. E104Q in loop III and E140Q in loop IV. The study involves determination of Ca2+ binding con

Water 17O longitudinal and transverse relaxation rates have been measured in aqueous solutions and mesophases of the non-ionic alkyl oligo(ethylene oxide) surfactants C12En (n = 4, 5, 8) over wide ranges of temperature and concentration. In addition, two reference systems have been investigated: high molecular weight poly(ethylene oxide) and the dimer 1,2-dimethoxy ethane. The relaxation data are