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Cytogenetic and fluorescence in situ hybridization characterization of clonal chromosomal aberrations and CCND1 amplification in esophageal carcinomas

Cytogenetic analyses of four squamous cell carcinomas (SCC) of the esophagus showed complex numerical and structural abnormalities. Chromosomal bands or regions preferentially involved were 11q13, 8q10, 21q10, 3p10similar top11, 1p11similar toq11, 5p11similar toq11, and 14p11similar toq11. For the first time, to our knowledge, recurrent aberrations were identified in esophageal SCC, including homo

Analys av sårbarhet med hjälp av nätverksmodeller

This report presents the research concerned with vulnerability analysis of technical infrastructure networks conducted in the research framework programme called FRIVA. The report reviews how network analysis has been used to analyse the vulnerability of systems that are possible to model as networks, such as technical infrastructure systems. In addition, it proposes how these methods can be devel

Beyond Space. Border Making in European Integration, the case of Ireland

The current ambition to enlarge the European Union (EU) from fifteen to twenty-seven member states has brought to the fore questions about European integration and its overarching aim. On 7 June, 2001, the Irish people decided not to ratify the Nice Treaty. However, the Irish 'no' was not considered to be an expression of political resentment that could impinge on further development of European i

En främling i det svenska landskapet - Om en Agave americana i Uppland på stormaktstiden

In September, 1708, for the first time ever in Sweden, an Agave americana (Aloe americana) was in bloom in Sweden. That event attracted much attention: four poets (Magnus Rönnow, Sophia Elisabet Brenner, Tobias Schubarth and Olof Rudbeck the younger) wrote poems in honour of the plant (and its owner, Count Nils Gyldenstolpe). The article analyses the differences between the poems and tries to expl

Abrupt climatic changes and an unstable transition into a late Holocene Thermal Decline: a multiproxy lacustrine record from southern Sweden

The transition from a middle Holocene relatively warm and stable climate to a cooler and unstable late Holocene climate is reconstructed using sediments from Lake Igelsjon, south-central Sweden. This multiproxy study illustrates local, regional and global scale responses to climatic change by focusing on a previously identified abrupt hydrological shift to cooler and/or wetter conditions around 40

Power, Person, and Place : Tradition, Modernity, and Environment in the United Arab Emirates

Popular Abstract in Swedish Avhandlingen undersöker naturumgängets modernisering i Förenade Arabemiraten, en federation av sju shejkdömen på den arabiska sidan av Persiska Viken. De traditionella näringarna var handel, pastoralism, fiske och pärlfiske, men dessa har sedan 1960-talet ersatts av en ekonomi baserad på export av fossila bränslen. Landet har under kort tid övergått från att vara ett trThe thesis investigates human-environmental relations in the rapidly modernizing United Arab Emirates, a federation of seven Arabian Gulf sheikhdoms. Since its establishment in 1971, the UAE has been transformed from a subsistence society based mainly on pastoralism and maritime activities (fishing, pearling, and trade) into an ultramodern society, with an economy based on the export of fossil fue

A small and compact AMS facility for tritium depth profiling

A dedicated AMS facility for depth profiling of tritium in carbon samples has been installed, tested and applied to routine measurements in the Forschungszentrum. Rossendorf. It is based on an SF6-insulated 100 kV tandem accelerator equipped with a thin diamond-like carbon (DLC) stripper foil of about 1 mug/cm(2). With this setup carbon samples with tritium concentrations in the range of 5 x 10(10

Non-perturbative calculation of 2D spectra in heterogeneous systems: Exciton relaxation in the FMO complex

Experimental 2D frequency resolved spectra showing the relaxation of excitons in the photosynthetic antenna system FMO are reproduced by a multi-exciton density matrix approach explicitly including the external fields. The interference of the polarizations of a number of randomly placed, rotated and energetically inhomogencous complexes is used to extract the signal in the phase matching direction

Accurate sample-and-hold circuit model

An accurate circuit model is presented for the general sample-and-hold circuit with a finite sampling duration. The applications of the model, such as to design a direct down-conversion sampler (RF sampler) and to calculate the thermal noise and output SNR of the general sample-and-hold circuit, are discussed. The results provide a theoretical basis for understanding and designing a sample-and-hol

Lower proliferation rate in metastatic effusion mesothelial cells than in benign effusions.

OBJECTIVE: To determine the proliferation rates of mesothelial cells in metastatic and benign effusions. STUDY DESIGN: Immunohistochemistry was performed on formalin-fixed pellets from 16 malignant and 9 benign clinical effusions. Dual staining with antibodies against Ki-67 (MIB-1) and desmin was applied to all effusions to differentiate between benign mesothelial cells and malignant cells, and th

Urinary N-acetyl-beta-D-glucosaminidase activity does not predict development of diabetic nephropathy

Urinary activity of N-acetyl-beta-D-glucosaminidase (NAG) has been suggested as a marker for diabetic nephropathy. In this study, urinary activity of NAG was measured with an interval of 5 yr in 36 insulin-dependent diabetic subjects to evaluate its predictive value for development of diabetic nephropathy. During the observation period, 9 patients developed detectable signs of diabetic nephropathy

Neonatal exposure to DDT and its fatty acid conjugate: effects on cholinergic and behavioural variables in the adult mouse

We have recently observed that DDT and a DDT metabolite, DDOH, conjugated to a fatty acid, palmitic acid, DDOH-PA, affects muscarinic cholinergic receptors (MAChR) in the neonatal mouse brain when given to suckling mice during rapid brain growth. This early exposure of the neonatal mouse also affects the behaviour of the animals as adults. When DDT and DDOH-PA was given as a single low oral dose o

A standard format for Les Houches Event Files

A standard file format is proposed to store process and event information, primarily output from partoti-level event generators for further use by general-purpose ones. The information content is identical with what was already defined by the Les Houches Accord five years ago, but then in terms of Fortran commonblocks. This information is embedded in a minimal XML-style structure, for clarity and

A Monolithic Digital Clock-Generator for On-Chip Clocking of Custom DSP's

This paper shows a robust and easily implemented clock generator for custom designs. It is a fully digital design suitable for both high-speed clocking and low-voltage applications. This clocking method is digital, and it avoids analog methods like phase locked loops or delay line loops. Instead, the clock generator is based on a ring counter which stops a ring oscillator after the correct number