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Hereditary non-polyposis colorectal cancer (HNPCC) is one of our most common cancer syndromes and an increasing number of individuals live in families with verified hereditary cancer. We conducted an interview study to explore experiences from and perceived impact on life after genetic testing for HNPCC. Three major themes emerged: reactions and emotions, family relations and implications for life

This article outlines an experimental and analytical expression study on the consequence of cement constituents, mix composition and curing conditions as regards self-desiccation in concrete. For this purpose nine concretes with three values of w/c (0.32, 0.38 and 0.50), based on two types of Portland Cement, were manufactured. Five per cent silica fume was used in one third of the concretes as ca

The existence of a DNA polymorphism at the hormone-sensitive lipase locus could be of great interest for genetic analysis of obesity and related disorders since hormone-sensitive lipase is the rate-limiting enzyme of adipose tissue lipolysis and therefore plays a key role in energy metabolism. The polymorphic dinucleotide repeat D19S120 was identified within a human genomic clone selected with a r

We present calculations of charm and beauty production at Tevatron within the framework of k(T)-factorization, using the unintegrated gluon distributions as obtained from the Linked Dipole Chain model. The analysis covers transverse momentum and rapidity distributions and the azimuthal correlations between b and (b) over bar quarks (or rather muons from their decay) which are powerful tests for th

Various new prognostic indicators have been identified for mammary carcinomas, but the issue of their significance remains unsettled. The prognostic impact of p53, c-erbB-2, and topoisomerase II alpha expression was investigated in relation to standard prognostic factors for carcinomas of the breast and to the tumour cell growth fraction. Paraffin-embedded specimens of 356 node-negative infiltrati

Estimation of parameters in the distribution of headways in roundabouts is a cumbersome task. Inherent to data employed are temporal variation together with dependence between successive vehicles. This is a consequence of the sampling period and interactions in the roundabouts. The elimination of observations, so as to obtain trend-free samples of independent vehicles, removes too much information

MAX-lab has introduced a local perturbation to the electron orbit of the MAX II storage ring, providing users at the SX700 monochromator beam line, D1011, with elliptically polarised soft X-rays. This is achieved by using corrector magnets to send the electron orbit on an ascending or descending trajectory through the dipole magnet source. This simple "bump" approach has many advantages over and a

Confronting grand canonical titration Monte Carlo simulations (MC) with recently published titration and charge reversal (CR) experiments on silica surfaces by Dove and Craven (Dove, P. M.; Craven, C. M. Geochim. Cosmochim. Acta 2005, 69, 4963-4970) and van der Heyden et al. (van der Heyden, F. H. J.; Stein, D.; Besteman, K.; Lemay, S. G.; Dekker, C. Phys. Rev. Lett. 2006, 96, 224502), we show tha

Aim: The objective of this study was to describe patients who experienced an out-of-hospital cardiac arrest (OHCA) by age group. Methods: All patients who suffered from an OHCA between 1990 and 2005 and are included in the Swedish Cardiac Arrest Registry (n = 40,503) were classified into the following age groups: neonates, younger than 1 year; young children, between 1 and 4 years; older children,

Kernel density estimation is an important tool in visualizing posterior densities from Markov chain Monte Carlo output. It is well known that when smooth transition densities exist, the asymptotic properties of the estimator agree with those for independent data. In this paper, we show that because of the rejection step of the Metropolis-Hastings algorithm, this is no longer true and the asymptoti

DNA interacts with insoluble monolayers made of cationic amphiphiles as well as with monolayers of zwitterionic lipids in the presence of divalent ions. Binding to dioctadecyldimethylammonium bromide (DODAB) or distearoyl-sn-glycero-3-phosphocholine (DSPC) monolayers in the presence of calcium is accompanied by monolayer expansion. For the positively charged DODAB monolayer, this causes a decrease

A synthesis of the early Holocene climatic development in the North Atlantic region is presented, based on three previously published lake records from southern Greenland (Lake N14), Iceland (Lake Torfadalsvatn) and the Faroe Islands (Lake Lykkjuvotn). The interval 11500-8500 cal BP has been divided into five phases with respect to the inferred strength of the North Atlantic Current (NAC) and Irmi

Partial lesions of the nigrostriatal dopamine system have been investigated with respect to their ability to induce consistent long-lasting deficits in movement initiation and skilled forelimb use. In eight different lesion groups 6-hydroxydopamine (6-OHDA) was injected at one, two, three, or four sites into the lateral sector of the right striatum, in a total dose of 20-30 microgram. Impairments

Affinity chromatography is routinely used mostly on a preparative scale to isolate different biomolecules such as proteins and carbohydrates. To this end a variety of proteins is in common use as ligands. To extend the arsenal of binders intended for separation of carbohydrates, we have explored the use of carbohydratebinding modules (CBM) in affinity chromatography. The thermostable protein CBM4-

As voice over IP proliferates, packet loss concealment (PLC) at the receiver has emerged as an important factor in determining voice quality of service. Through the use of heuristic variations of signal and parameter repetition and overlap-add interpolation to handle packet loss, conventional PLC systems largely ignore the dynamics of the statistical evolution of the speech signal, possibly leadin

Objectives: To develop an automated tool for the analysis of electrocardiograms (ECG) with respect to changes that make the patient a candidate for reperfusion therapy. An additional aim was to assess the influence of the tool on the ECG classifications of three interns. Methods and Results: An artificial neural network was trained to interpret ECGs regarding changes making the patient a candi

This study is a long-term follow-up in narrative form of three former psychiatric patients who had been discharged eight to nine years earlier from an outpatient occupational therapy programme. The purpose of the study was to gain an understanding about the participants' views about the period of therapy from a long-term perspective and of how the outcome of therapy could be understood within the

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OBJECTIVES: Metabolic factors such as obesity, hypertension, dyslipidemia and hyperglycemia have consistently been associated with increased risk of cardiovascular disease. There is also growing evidence that these factors are linked to cancer incidence and mortality. The aim of this study was to investigate long-term trends in major metabolic risk factors in three large cohorts. MATERIALS AND MET