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Background: Fentanyl is commonly administered for procedural pain management in preterm infants, but target concentrations have not yet been defined. Methods: To investigate pharmacokinetics (PK), -dynamics (PD), and -genetics (PG), 25 infants (gestational age 23.3–34.1 weeks) received a fentanyl dose before a skin-breaking procedure (0.5 µg/kg) or tracheal intubation (2 µg/kg). Four pain scales w
Centrifugal compressors are widely used in turbocharged powertrains for Heavy-Duty applications. The volute of the centrifugal compressors is generally of the overhung type. The design of volutes is often neglected, and the shape of the volute is dictated by the packaging requirements of the engine. However, with the advent of Hydrogen-based propulsion systems, the efficiency of all the components
Let (X, μ, T , d) be a metric measure-preserving dynamical system such that three-fold correlations decay exponentially for Lipschitz continuous observables. Given a sequence (Mk) that converges to 0 slowly enough, we obtain a strong dynamical Borel.Cantelli result for recurrence, that is, for μ-almost every x ∈ X, {equation presented} where μ(Bk(x)) = Mk. In particular, we show that this result h
In urban property development projects, attention to the needs and aspirations of local communities is often neglected. Although some developers still consider local community stakeholders to be a potential threat to their developments, in many developed countries, stakeholder participation is embedded within statutory processes such as the formal planning process and is increasingly regarded as a
The coupling between fluid-structure interactions is governed by the pressure distribution over the interaction surface between the fluid and solid domains. The capabilities of non-intrusive optical techniques, such as particle image velocimetry and Lagrangian particle tracking (LPT), have been proven to provide accurate velocity and acceleration information within the flow field while simultaneou
Background and purpose: National quality registries for stroke care operate under the assumption that the included patients are correctly diagnosed. We aimed to validate the clinical diagnosis of spontaneous intracerebral hemorrhage (ICH) in Riksstroke (RS) by evaluating radiological data from a large, unselected ICH population. Methods: We conducted a retrospective, multicenter study including al
Objectives: Lung squamous cell carcinoma (LUSC) is associated with a poor prognosis and a lack of specific treatment options. The dysregulation of activin A (ActA) has been reported in various malignancies. Herein, we investigated the diagnostic and prognostic significance of ActA in LUSC. Materials and methods: ActA concentrations were measured using ELISA in plasma samples of 128 LUSC patients (
Purpose: To examine anthropometric predictors of BMI 30 years after the onset of adolescent AN. Methods: A group of 51 individuals with adolescent-onset AN were identified in Sweden in 1985. Anthropometric data have been collected from birth records and school nurse charts. A group matched for gender, school and age constituted a healthy control group. Possible predictors of BMI 30 years after AN
The axillary lymph node status remains an important prognostic factor in breast cancer, and nodal staging using sentinel lymph node biopsy (SLNB) is routine. Randomized clinical trials provide evidence supporting de-escalation of axillary surgery and omission of SLNB in patients at low risk. However, identifying sentinel lymph node macrometastases (macro-SLNMs) is crucial for planning treatment ta
Tendon healing involves mechanosensitive cells that adapt to mechanical stimuli through mechanotransduction, resulting in increased tissue strength. However, detailed insights into this process in response to different loads remain limited. We aimed to investigate how different loading regimes impact the spatial composition of elastin and collagens during Achilles tendon healing. Histological anal
Introduction: Studies suggest that experiences of patient participation, as described by both patients and staff, are associated with a significant caring relationship of high quality. Aim: This study aimed to investigate staffs' and patients' self-reported perceptions on participation and the frequency and importance of verbal and social interactions in high-security forensic psychiatry. Method:
Building occupant behaviour is known to be an important factor that drives building energy use and the associated carbon emissions. A substantial body of work has investigated occupant behaviour and the underlying drivers. Yet it is generally known that some buildings allow only minimal behavioural intervention, such as on/off control of lights. Other buildings allow a much higher degree of interv
Background: Hepatitis C virus (HCV) infection can lead to a type of primary liver cancer called hepatocellular carcinoma (HCC). Georgia, a high HCV prevalence country, started an HCV elimination program in 2015. In addition to tracking incidence and mortality, surveillance for the HCV-attributable fraction of HCC is an important indicator of the program’s impact. This study assesses HCV infection-
In the low deposition situation of today at many of the long-term Swedish forest monitoring sites, the deposition measured as precipitation to the open field, i.e. bulk deposition of oxidized sulphur (S) is often higher or equal to deposition of S sampled under the forest canopies, i.e. as throughfall. This suggests that the total S deposition estimated using throughfall is underestimated. The rea
Non-structural protein 3 (Nsp3) is the largest protein encoded by the coronavirus (CoV) genome. It consists of multiple domains that perform critical functions during the viral life cycle. CoV-Y is the most C-terminal domain of Nsp3, and it exhibits evolutionary conservation across diverse CoVs; however, the exact biological function of CoV-Y remains unclear. Here, we determined the crystal struct
Some dinoflagellates produce toxic secondary metabolites that correlate with increased resistance to grazers. The allocation costs of toxin production have been repeatedly addressed, but with conflicting results. Few studies have considered the potential costs of this defense to the photosystem, even though defense toxins (e.g., karlotoxins and brevetoxins) are closely linked to the photoprotectiv
