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Acute myeloid and acute lymphoblastic leukemia (AML and ALL) harboring KMT2A rearrangements (KMT2A-R) constitutes a type of leukemia with inferior outcome and high likelihood of relapse, especially when occurring in infants < 1 year of age. We analyzed paired diagnose and relapse samples from Whole Genome Sequenced (WGS) and Whole Exome Sequenced (WES) data to model the genetic evolution from diag
