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The prospect of being able to efficiently inject large plasmids in insulin-producing beta cells is very attractive for diabetes research. However, conventional transfection methods suffer from high cytotoxicity or low transfection efficiency, which negatively affect their outcome. In contrast, nanostraw electroporation is a gentle method that can provide a high transfection efficiency while mainta

"Storsjöodjuret”, eller “The Great Lake Monster”, är ett undflyende fenomen i sjön Storsjön, belägen i landskapet Jämtland i norra Sverige. Denna avhandling i ämnet humanekologi undersöker hur det sammankopplingar av det sociala, det kulturella, det historiska och det lokala påverkar formandet av detta svenska kryptid, eller “dolda djur”. Syftet med studien är att visa hur detta vetenskapligt ännuStorsjöodjuret, or The Great Lake Monster, is an elusive phenomenon in lake Storsjön, situated in the province of Jämtland in Northern Sweden. This dissertation in Human Ecology investigates how the intricate web of the social, the cultural, the historical, and the local influence the shaping of this Swedish cryptid, or “hidden animal”. The purpose of the study is to demonstrate how this scientifi

In wildland fires, burning particles of vegetative material can be lofted by the fire plume and are subsequently transported horizontally by cross wind. Depending on the state of the firebrands (flaming, smoldering, inert hot, inert cold) upon landing they bear the potential to cause secondary fires. The present work introduces the reader to existing theoretical analyses of the problem of combusti

In this thesis, we investigate low-dimensional magnetic systems from the theoretical points of view. To address situations with several and distinct magnetic interactions, we develop different frameworks, including a magnon self-energy approach, a spin dynamical exchange-correlation (xc) field formalism and a scheme combining Matrix Product States method and exact diagonalization/nonequilibrium Gr

Neutron spectroscopy uniquely and non-destructively accesses diffusive dynamics in soft and biological matter, including for instance proteins in hydrated powders or in solution, and more generally dynamic properties of condensed matter on the molecular level. Given the limited neutron flux resulting in long counting times, it is important to optimize data acquisition for the specific question, in

Protein interactions in solution and the question of cluster formation are of paramount importance to a wide range of research fields and industrial applications. Protein clustering can arise due to a delicate interplay between the short-range attraction and the long-range repulsion in the interaction potential. This study employs small angle X-ray scattering (SAXS) to examine the clustering behav

Bacterial exopolysaccharides (EPS) have emerged as one of the key players in the field of heavy metal-contaminated environmental bioremediation. This study aimed to characterize and evaluate the metal biosorption potential of EPS produced by a novel Psychrobacillus strain, NEAU-3TGS, isolated from an iron ore deposit at Tamra iron mine, northern Tunisia. Genomic and pan-genomic analysis of NEA

PURPOSE: There is a lack of validated imaging biomarkers for prediction of response to peptide receptor radionuclide therapy (PRRT). The primary objective was to evaluate if tumour burden at baseline PET/CT could predict treatment outcomes to PRRT with [ 177Lu]Lu-DOTA-TATE. Secondary objectives were to evaluate if there was a correlation between tumour burden and mean tumour absorbed dose (AD) dur

In this article, structured laser illumination planar imaging and polarization ratio techniques are successfully combined to size droplets in various optically dense sprays. The polarization ratio approach is based on the acquisition of the perpendicular and parallel polarized components of Lorenz–Mie scattered light, for which the ratio is proportional to the surface mean diameter, D21. One of th

Study objectives: We examined and compared cross-sectional and longitudinal associations between self-reported sleep disturbances and various cognitive domains in five separate Nordic European longitudinal aging studies (baseline N = 5631, mean age = 77.7, mean follow-up = 4.16 years).Methods: Comparable sleep parameters across studies included reduced sleep duration/quality, insomnia symptoms (sl

AimSpeech difficulties are common in children with cleft palate, but research on foreign-born children is limited. This study aimed to compare speech outcomes, surgery and speech intervention in 5-year-old foreign-born and Swedish-born children with cleft palate with or without cleft lip.MethodsThis retrospective study analysed data from the Swedish cleft lip and palate registry for children born

Background: Research suggests that incident dementia is decreasing, yet researchon secular trends of prodromal dementia such as mild cognitive impairment (MCI) islacking.Methods: To determine change ofMCI prevalence over time and potential explanatoryfactors, four baseline samples (years 2001–2020) of Swedish participants (n = 3910)aged 60 and 81 at examination were compared.Results: An overall dr

ObjectiveDevelopment of an AI tool to assess velopharyngeal competence (VPC) in children with cleft palate, with/without cleft lip.DesignInnovation of an AI tool using retrospective audio recordings and assessments of VPC.SettingTwo datasets were used. The first, named the SR dataset, included data from follow-up visits to Skåne University Hospital, Sweden. The second, named the SC + IC dataset, w