Sökresultat

Sweden has experienced a national value-based pricing (VBP) system for innovative outpatient drugs operated by the Pharmaceutical Benefits Board - LFN (now called the Dental and Pharmaceutical Benefits agency - TLV) since 2002. VBP has the character of a monopoly system, leading to reimbursement decisions where usage of new medicines is limited to subgroups and not the population for which the dru

The susceptibility to enzymatic hydrolysis of starch extracted from raw roots of Canna indica, Manihot esculenta and Xanthosoma sagittifolium, grown in Bolivia, were studied below the gelatinization temperature. The granule size and amylose content were as followed: C. indica>M. esculenta>X. sagittifolium. The hydrolysis showed a rapid rate at the initial stage, followed by a progressive decrease

Objective: To evaluate aggrecanase activity after traumatic knee injury in a rat model by measuring the level of aggrecanase-generated Ala-Arg-Gly-aggrecan (ARG-aggrecan) fragments in synovial fluid, and compare with ARG-aggrecan release into joint fluid following human knee injury. To evaluate the effect of small molecule inhibitors on induced aggrecanase activity in the rat model. Method: An enz

The use of household electricity and domestic hot water has been measured for 72 apartments in an apartment building located in the south of Sweden. The measurements were carried out with samples every 6 s, a tenfold increase in resolution compared to available published data, during a measurement period of five days, in the winter season, including a weekend. The influence of the time resolution

BACKGROUND: Brain injury is considered the main cause of death in patients who are hospitalized after cardiac arrest (CA). Induced hypothermia is recommended as neuroprotective treatment after (CA) but may affect prognostic parameters. We evaluated the effect of delayed neurological prognostication on the mode of death in hypothermia-treated CA-survivors. STUDY DESIGN: Retrospective study at a Swe

Abstract in Uncoded languages U ranijim viktimološkim istraživanjima naglašene su jednostrane slike kategorije „žrtva“ i „zločinac“. Istraživači su isticali važnost priča i usmjerili fokus analize na priče o viktimizaciji, ali istraživači nisu analizirali poslijeratne intervjue kao arenu gdje se odigrava borba za status žrtve. Ovim člankom pokušava se popuniti ta praznina analiziranjem priča 27 osPrevious research on victimhood often has presented a one-sided picture of the “victim” and “perpetrator”. Researchers have emphasized the importance of narratives and they have focused on narratives about victimhood, but a researcher has not analyzed post-war interviews as a competition for victimhood. This article tries to fill this gap using stories told by survivors of the Bosnian war during t

We study analytically the tracer particle mobility in single-file systems with distributed friction constants. Our system serves as a prototype for nonequilibrium, heterogeneous, strongly interacting Brownian systems. The long time dynamics for such a single-file setup belongs to the same universality class as the Rouse model with dissimilar beads. The friction constants are drawn from a density r

Purpose: To explore how the rehabilitation plan influences the rehabilitation process and its outcome in people with late effects of polio participating in an individualised goal-oriented interdisciplinary rehabilitation programme. Methods: Four women and two men with late effects of polio were interviewed before rehabilitation, at discharge, and at follow-up. Data were analysed according to the c

We investigated test to retest reliability and intraindividual variability of Romberg ratios in quiet stance posturography. Thirty-six healthy young adults (17 males, 19 females aged 15-38 years) were divided into 3 groups with different time-intervals between consecutive trials (20min, 3h and 24h respectively). Each group performed 5 posturography recordings in a randomized order of eyes open (EO

We describe the possibility to create solid-like protein samples whose structural and mechanical properties can be varied and tailored over an extremely large range in a very controlled way through an arrested spinodal decomposition process. We use aqueous lysozyme solutions as a model globular protein system. A combination of video microscopy, small-angle neutron and X-ray scattering and reverse

Breast-cancer-derived cell lines are an important sample source for cancer proteomics and can be classified on the basis of transcriptomic analysis into subgroups corresponding to the molecular subtypes observed in mammary tumors. This study describes a tridimensional fractionation method that allows high sequence coverage and proteome-wide estimation of protein expression levels. This workflow ha

The genus Klyngon Hansson is revised and expanded to include 13 species, 11 of which are newly described: K. albicornis, K. aulacis, K. brasilense, K. copaiferae, K. costalimai, K. gibberum, K. guimaraesi, K. hortense, K. pegosoma, K. petalon, K. serjaniae. The inclusion of the new species necessitates a change of the morphological definition of the genus and diagnostic characters are modified or

The Environmental Determinants of Diabetes in the Young (TEDDY) study is designed to identify environmental exposures triggering islet autoimmunity and type 1 diabetes (T1D) in genetically high-risk children. We describe the first 100 participants diagnosed with T1D, hypothesizing that (i) they are diagnosed at an early stage of disease, (ii) a high proportion are diagnosed by an oral glucose tole

To describe 2-year and long-term outcomes (five or ten years) after resective epilepsy surgery in children operated before the age of four years.

A central hurdle in developing small interfering RNAs (siRNAs) as therapeutics is the inefficiency of their delivery across the plasma and endosomal membranes to the cytosol, where they interact with the RNA interference machinery. With the aim of improving endosomal release, a poorly understood and inefficient process, we studied the uptake and cytosolic release of siRNAs, formulated in lipoplexe

Exposure to cadmium (Cd) has long been recognized as a health hazard, both in industry and in general populations with high exposure. Under the currently prevailing health risk assessment, the relationship between urinary Cd concentrations (U-Cd) and tubular proteinuria is used. However, doubts have recently been raised regarding the justification of basing the risk assessment on this relationship

The enforcement and implementation of separate aspects of sustainable development and environmental sustainability can be challenging and innovative due to the complexity of this task. Appropriate policy and legal approaches and tools can be needed for this purpose. In this article, the EU experience of developing the framework for sustainable transport biofuels and special structural elements for