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Background: There is an increasing incidence of oropharyngeal squamous cell carcinoma (OPSCC) survivors living with treatment-related head and neck lymphedema (HNL). This study aimed to determine (i) the prevalence of external HNL, (ii) changes in HNL over a nine-month period post-treatment, and (iii) factors associated with HNL among patients with OPSCC treated with (chemo)radiotherapy. Methods a
Three-dimensional (3D) cultures of primary human hepatocytes (3D PHH) are successfully used to reduce and replace the use of animal experiments in biomedical research. Yet, the initial formation of 3D PHH is highly dependent on the supplementation with FBS. However, the molecular composition of FBS and its effects on cultured cells are poorly understood. Moreover, FBS is prone to batch-to-batch va
Polyploidy is an important driver of the evolution and diversification of flowering plants. Several studies have shown that established polyploids differ from diploids in floral morphological traits and that polyploidization directly affects these traits. However, for floral scent, which is key to many plant-pollinator interactions, only a few studies have quantified differences between establishe
OBJECTIVES: To describe the prevalence of cardiovascular disease (CVD) at the time of diagnosis of adult-onset type 1 (T1D) and type 2 (T2D) diabetes, in a recent cohort and compare to a previous cohort from the same region. Further, to explore factors influencing the prevalence of pre-existing CVD, including age, sex, body mass index (BMI) and C-peptide; in the later cohort also heart failure, hy
Purpose: Ovarian cancer ranks as a gynecological malignancy with poor prognosis, specifically if detected late. Primary treatment includes cytoreductive surgery and adjuvant chemotherapy with curative intent. Local anesthetics (LA) administered in the perioperative period may potentially impact patient outcome by several mechanisms. The beneficial impact of LA has been attributed, among other fact
The conversion of CO 2 into high-value chemicals through a photoreduction reaction in water is a promising route to reduce the dependence on fossil fuels. Enhancing selectivity toward hydrocarbons or alcohols can be achieved by Ag-Cu alloys. However, the stabilized surface state created by Ag-Cu interactions is still poorly understood. In this work, multi-modal in situ X-ray experiments reveals u
The adsorption and activation energetics underpinning small molecule conversion on heterogeneous (photo)-electrocatalysts are intrinsically tied to catalyst surface properties. Absent compositional characterization techniques with sufficient interface sensitivity, however, (photo)-electrochemical performance can be misinterpreted in the context of bulk or near-surface material properties. Here we
Nowadays, Pt-CeO2 interfaces are very popular in many applications. In particular, this system is widely used in catalysis for the reverse water gas-shift (RWGS) reaction aiming to stop the dangerous advancement of the global warming effect. Nevertheless, some complex atomic events occurring at this interface are still unclear. In this work, superhydrophobic Pt-CeO2 nanoparticles were used in the
Dyes are routinely used in the textile and pharmaceutical industries, causing serious environmental issues by decreasing water quality. Photocatalysts are used for dye degradation, and different acting mechanisms may occur during the photodegradation process. In this study, Ni nanoparticles were heated to selected temperatures up to 500 °C under an ambient atmosphere and subsequently supported on
The development of thermally stable nanoparticles is of utmost importance for applications like catalysis. In particular, Cu nanoparticles supported on metal oxides are easily deactivated under thermal treatments at low temperatures by sintering of the Cu nanoparticles. The formation of thermally stable nanoparticles is typically obtained with secondary drawbacks. In this study, an alternative met
Climate litigation is growing and increasingly targets corporate actors. Scientific evidence is crucial in climate court cases, for instance to determine plaintiffs’ standing to sue or the attribution of climate impacts to the defendants’ actions. However, it remains unknown how scientific expertise influences court decisions, what forms of expertise are used, how evidence is contested, and how ju
Atomic vacancies are primordial for controlling the photocatalytic activity of perovskites. On the one hand, they are useful adsorption sites and help narrow the band gap, but they may also trap the electron-hole pair created after light absorption. Its precise control, although essential, is hardly achieved with traditional methods. In this work, an alternative experimental approach is employed t
The importance of immunometabolism in the development of metabolic diseases is clear. Yet, how certain metabolic disorders, such as insulin deficiency (ID), influence immune cell function, and vice versa, is poorly understood. Also, therapeutic strategies to harness the interplay between immune cells and metabolism are lacking. Here, we observe that ID rearranges the immune landscape of the liver,
Background: Multiple clinical practice guidelines and head computed tomography decision rules exist for emergency department (ED) triage of children with traumatic brain injury (TBI). These vary in structure, aim, target cohort, and outcomes, yet are used clinically in similar populations. We compared important clinical and practical characteristics of all major guidelines in a large, real-world p
Despite efforts to integrate BIM and BEM, challenges persist, including incomplete data, errors, and the need for manual corrections, all hindering the implementation of sustainable building designs. Professionals in the Swedish architecture, engineering, and construction (AEC) industry have yet to fully adopt standardized practices for exchanging BIM and BEM data. This article explores the challe
Market-based climate policies have received increased attention, making it important to understand how they affect competition in the electricity market. This paper focuses on the green certificate policy which financially supports producers of renewably sourced electricity by means of tradable certificates, and develops a duopoly model that incorporates both the electricity and the green certific
The European Association of Urology (EAU) 2021 prognostic model for non–muscle-invasive bladder cancer (NMIBC) is based on the World Health Organization (WHO) 1973 and/or WHO 2004/2022 grading systems for patients who did not receive bacillus Calmette-Guérin (BCG) instillations and is widely used to assess the risk of progression. The estimated risk of progression affects the type of adjuvant intr
Background: The multifactorial nature of chronic pain should be reflected in pain assessment. The aim of this observational study comparing samples from three generations assessed at different times was to present differences in pain, stress and mental well-being. Methods: Pain sites, widespread pain, stress (Perceived Stress Scale-4) and mental well-being (30-item General Health Questionnaire) we
Study region: The Limpopo River Basin (LRB) is a transboundary catchment in Southern Africa, shared by South Africa, Botswana, Zimbabwe, and Mozambique. The basin is increasingly affected by climate variability, land-use change, and rapid population growth, with the Chókwe floodplain in Mozambique representing a hotspot of socio-economic vulnerability to floods. Study focus: This study applies the
Improving energy efficiency in agriculture is key to reducing environmental impact. Lighting in animal buildings is one of the most cost‐effective energy saving measures. Lighting retrofit offers a short payback period, enhances animal welfare and production, and aligns with regulations for phasing out fluorescent lighting. The purpose of this study was to investigate the energy-saving potential o
