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Blood concentrations of lipoproteins and lipids are heritable risk factors for cardiovascular disease. Using genome-wide association data from three studies (n = 8,816 that included 2,758 individuals from the Diabetes Genetics Initiative specific to the current paper as well as 1,874 individuals from the FUSION study of type 2 diabetes and 4,184 individuals from the SardiNIA study of aging-associa

QR decomposition (QRD) is used to solve least squares (LS) problems for a wide range of applications. However, traditional QR decomposition methods, such as Gram-Schmidt (GS), require high computational complexity and non-linear operations to achieve high throughput, limiting their usage on resource-limited platforms. To enable efficient LS computation on embedded systems for real-time application

Attaining high peak bone mass (PBM), the highest bone mass value in life which is reached in young adulthood, is important as it reduces the risk of having low bone mass in old age69, 80. Low bone mass is associated with high fracture risk3, 60. Osteoporosis is the result of bone loss, a physiological process related to aging and/or low PBM. It would therefore be of great value to identify childre

Serotonin and dopamine are two monoamines which are known to interact with each other. Their role for suicidal behaviour, aggression and mood are reviewed in this chapter. We found a substantial amount of evidence for the relevance of a serotonin and dopamine model of aggression, and for aggression as a major risk factor for suicide. Evidence was found that serotonin and dopamine also may be invol

The proportions of newborns with a birth weight (BW) >4,000 g and of macrosomic newborns (BW >4,500 g) have increased during the last two decades, parallel with an increasing maternal pre-pregnancy body mass index (BMI) and age at the time for pregnancy. Delivery of a large fetus, especially >4,500 g might cause perinatal complications for both the mother and her child. The aims of this work were

We investigate electron localization in fully spin-polarized few-electron concentric double quantum rings submitted to a perpendicular magnetic field by means of density functional theory and exact diagonalization calculations. The variation of the applied magnetic field turns out to strongly affect the distribution of the electrons in such 'crystallized' configurations. A comparison and discussio

Allergen-specific immunotherapy (ASIT) in allergic rhinitis and asthma is the only treatment that effects the long-term development of these diseases. Basophil allergen threshold sensitivity, CD-sens, which is a valuable complement to resource-demanding clinical challenge tests, was used to monitor the initiation of ASIT induced allergen 'blocking activity'. Patients IgE-sensitized to timothy (n =

Light sensors are increasingly used to monitor vegetation growing status by measuring reflectance or transmittance in multispectral or photosynthetically active radiation (PAR) bands. The measurements are then used to estimate vegetation indices or the fraction of absorbed PAR (FPAR) in a continuous and long-term manner and to serve as inputs to environmental monitoring and calibration/validation

The study reported in this paper examines foreign accent (FA) in adult simultaneous bilinguals (2L1ers). Specifically, we investigate how accent is affected if a first language is acquired as a minority (heritage) language as compared to a majority (dominant) language. We compare the perceived FA in both languages of 38 adult 2L1ers (German-French and German-Italian) to that of monolingual native

PURPOSE. To determine the cellular consequences of retinal detachment in retinoschisin knockout (Rs1-KO) mice, a model for retinoschisin in humans. METHODS. Experimental retinal detachments (RDs) were induced in the right eyes of both Rs1-KO and wild-type (wt) control mice. Immunocytochemistry was performed on retinal tissue at 1, 7, or 28 days after RD with antibodies to anti-GFAP, -neurofilament

Road transportation has attracted extensive attention throughout the world because of its high energy demands and numerous externalities. Sustainable road transportation has thus become a great challenge for politicians and decision-makers all over the world. There have been a series of studies indicating that appropriate pricing of fuel can be both effective and efficient for reducing overconsump

Context The popularity of the open source software development in the last decade, has brought about an increased interest from the industry on how to use open source components, participate in the open source community, build business models around this type of software development, and learn more about open source development methodologies. There is a need to understand the results of research i

Popular Abstract in Swedish Bihåleinflammation (rinosinuit) definieras som inflammation av näsans och bihålornas slemhinna. Akut rinosinuit är den femte vanligaste orsaken till antibiotikaförskrivning. Kronisk rinosinuit verkar vara ett ökande hälsoproblem, som drabbar drygt 9% av Europas befolkning och innebär en stor belastning på hälsoekonomin. Amerikanska studier har visat att rinosinuit påverRhinosinusitis is defined as an inflammatory process involving the mucosa of the nose and one or more of the paranasal sinuses. The aims of the work presented in this thesis were to investigate the degree to which rhinosinusitis affects the health-related quality of life (HRQOL), and to determine whether the diagnosis of this condition can be improved using Doppler ultrasound. The HRQOL of 207 pa

A porphyrin -system has been modulated by enhancing the push-pull character with highly asymmetrical substitution for dye-sensitized solar cells for the first time. Namely, both two diarylamino moieties as a strong electron-donating group and one carboxyphenylethynyl moiety as a strong electron-withdrawing, anchoring group were introduced into the meso-positions of the porphyrin core in a lower sy

Tephra horizons are potentially perfect time markers for dating and cross-correlation among diverse Holocene palaeoenvironmental records such as ice cores and marine and terrestrial sequences, but we need to trust their age. Here we present a new age estimate of the Holocene Mjauvotn tephra A using accelerator mass spectrometry C-14 dates from two lakes on the Faroe Islands. With Bayesian age mode

Metabolomic screening of fasting plasma from nondiabetic subjects identified alpha-hydroxybutyrate (alpha-HB) and linoleoyl-glycerophosphocholine (L-GPC) as joint markers of insulin resistance (IR) and glucose intolerance. To test the predictivity of alpha-HB and L-GPC for incident dysglycemia, alpha-HB and L-GPC measurements were obtained in two observational cohorts, comprising 1,261 nondiabetic