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Head and neck squamous cell carcinomas (HNSCC) are often characterized by complex karyotypic changes, and a substantial proportion of the reported tumors have shown intratumor heterogeneity in the form of cytogenetically related (40%) or unrelated clones (20%). In order to study intratumor heterogeneity and to distinguish the temporal order of chromosome rearrangements in these tumors, two or more
OBJECTIVE: Glucagon-like peptide-1 (GLP-1) has been proposed as a new treatment modality for type 2 diabetes. To circumvent the drawback of the short half-life of GLP-1, inhibitors of the GLP-1-degrading enzyme dipeptidyl peptidase IV (DPP IV) have been examined. Such inhibitors improve glucose tolerance in insulin-resistant rats and mice. In this study, we examined the 4-week effect of 1-[[[2-[(5
Most couples therapy theories are developed and tested in the USA. In this clinical study, we investigated such therapies in a Swedish context. Over 300 couples were enrolled in the study of whom just under half completed the end-of-treatment assessment and just over 40 per cent a two-year follow-up. At the start, the study group displayed severe problems in marital adjustment, dyadic interactions
Plant and animal lectins with various carbohydrate specificities were used to type 35 Irish clinical isolates of Helicobacter pylori and the type strain NCTC 11637 in a microtiter plate assay. Initially, a panel of eight lectins with the indicated primary specificities were used: Anguilla anguilla (AAA), Lotus tetragonolobus (Lotus A), and Ulex europaeus I (UEA I), specific for -L-fucose; Solanum
1. The invasive golden apple snail (Pomacea canaliculata), native to South America, is a serious pest on rice seedlings in south-east Asia and has also been shown to consume large amounts of macrophytes in natural wetlands, with large effects on ecosystem functioning. Earlier studies suggest that the snail undergoes an ontogenetic diet shift, feeding on algae and detritus as juveniles and shifting
Bioelectrocatalytic reduction of H2O2 catalysed by lignin peroxidase from Phanerochaete chrysosporium (LiP) was studied with LiP-modified graphite electrodes to elucidate the ability of UP to electro-enzymatically oxidise phenols, catechols, as well as veratryl alcohol (VA) and some other high-redox-potential lignin model compounds (LMC). Flow-through amperometric experiments performed at +0.1 V v
A method for simulating the cooled gas turbine is demonstrated. Based on equations and other knowledge found in the literature, a first-law thermodynamic, non-dimensional model is established and implemented in the equation-solving, programmable software IPSEpro. Increasing the water vapor or carbon dioxide contents of the gas turbine hot gas is found not to have an impact on the Stanton number,
In this paper, a method of assessing water quality from satellite data is introduced. The composite pollution index (CPI) was calculated from measured chemical oxygen demand (COD) and nutrient concentration. The relationships between CPI and 240 band combinations of SeaWiFS water-leaving radiance were analyzed and the optimal band combination for estimating CPI was chosen from the 240 band combina
Various lines of evidence suggest a respiratory route of transmission of nephropathia epidemica (NE). To study the response of the respiratory tract in NE, fiberoptic bronchoscopy with bronchoalveolar lavage (BAL) was performed in 5 patients in the acute phase of the disease. Compared to a reference group of 15 healthy individuals, BAL fluid of NE patients contained significantly higher total numb
Six years ago we reported the discovery of a central place at Uppakra in southern Sweden which promised to be unusually rich and informative (Hardh 2000). At 40ha it already stood out as the largest concentration of residual phosphate in the whole province of Scania, with surface finds of Roman and late Iron Age metalwork (second-tenth century AD). Following this thorough evaluation, the project m
The blood group ABO gene codes for a glycosyltransferase that adds the ultimate monosaccharide to a glycoconjugate and forms the A or B blood group specific antigen. The DNA structure of the three major alleles of the human blood group ABO system was first described in 1990. This review describes the subsequent developments, including the increasing number of variants of these common alleles and t
Context. The stellar abundance ratio of Mg/Fe is an important tool in diagnostics of galaxy evolution. In order to make reliable measurements of the Mg abundance of stars, it is necessary to have accurate values for the oscillator strength (f- value) of each of the observable transitions. In metal-poor stars the MgI 3p-4s triplet around 5175 angstrom (Fraunhofer's so-called b lines) are the most p
Popular Abstract in Swedish Ojämnheter i vägen orsakar påkänningar i åkande fordon. För fordonstillverkare är det intressant att veta egenskaperna hos dessa vägojämnheter. Det är lämpligt att använda statistiska metoder för att analysera mätningar av vägytor/vägprofiler, dels eftersom mätningarna ger stora mängder data och dels eftersom vägytor har ett slumpmässigt beteende (från en 100 meter långRoad profiles are studied from a vehicle fatigue point of view. A wide range of roads have been measured: from smooth motorways to very rough gravel roads. It is observed that the road profiles consist of irregular sections, which makes the stationary Gaussian model unsuitable (Paper A). In Paper B, a method for automatic identification of such irregularities is presented. It is verified that the
Background: Transcription factors are frequently involved in the process of cellular transformation, and many malignancies are characterized by a distinct genetic event affecting a specific transcription factor. This probably reflects a tissue specific ability of transcription factors to contribute to the generation of cancer but very little is known about the precise mechanisms that governs these
Object: The abdominal aorta (AA) has a predilection for aneurysm formation. An etiologic factor may be underlying aortic wall stress. The purpose of this study was to examine whether the intima-media thickness (IMT) of the AA, as a surrogate to arterial wall thickness, can be measured noninvasively with satisfactory results to calculate circumferential wall stress, and to evaluate regional and gen
