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Survival strategies of the human respiratory tract pathogen Haemophilus influenzae

Haemophilus influenzae is an important respiratory tract pathogen responsible for a variety of infections in humans. Encapsulated H. influenzae belongs to one of six serotypes (a-f), of which type b is the most virulent one causing serious and sometimes life-threatening diseases (e.g., epiglottitis, septicaemia and meningitis). In contrast, non-typeable H. influenzae (NTHi) accounts for the majori

Replacement names for three Swedish species of Hieracium (Asteraceae)

While working on a check-list of the Swedish species of Hieracium L. sect. Hieracium and H. sect. Vulgata (Griseb.) Willk. & Lange (now available at www.nrm.se/fbo/chk/ttlista/welcome.htmi), I found that three of the names in current usage were illegitimate, two being later homonyms and one superfluous when published. In this paper avowed substitutes (replacement names) for these names are pro

Integrating needs assessment within next generation e-learning systems: lessons learnt from a case study

In this paper we outline a method for systematically addressing needs assessment (QUALISEM-PEOPLE), alongside a case study of its use within a medium sized, German company. The method was designed in order to provide guidance in analysing skill and role competences, particularly when e-learning systems are being considered for training purposes. The method proved to be successful within the compan

The Possibility of Resonance-Enhanced Two-Photon Ionization of Ne and Ar Atoms in Astrophysical Plasmas

We consider possible schemes for the resonance-enhanced two-photon ionization (RETPI) of Ne and Ar atoms under the action of bichromatic radiation of intense resonance lines of HI, HeI, and HeII in a radiation-rich astrophysical plasma. The ionization rate is comparable to or exceeds the recombination rate in rarified astrophysical plasma, which leads to the accumulation of singly ionized ions wit

Fetal electrocardiogram: ST waveform analysis in intrapartum surveillance

ST waveform analysis of fetal electrocardiogram (ECG) for intrapartum surveillance (STAN) is a newly introduced method for fetal surveillance. The purpose of this commentary is to assist in the proper use of fetal ECG in combination with cardiotocography (CTG) during labour. Guidelines and recommendations concerning CTG and ST waveform interpretation and classification are stated that were agreed

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Role of R-(-)-deprenyl in adhesion of neuronal and non-neuronal cells. The beneficial effect of the anti-parkinsonian monoamine oxidase-B inhibitor, R-(-)-deprenyl has been shown in a number of different diseases, such as Parkinson's and Alzheimer's disease, atherosclerosis or tumor formation. The role of the cytoskeleton, the main component of cell adhesion, has been suggested in the development

Core-excited quintet states in Mg I

The low-lying core-excited quintet states of Mg I have been studied experimentally and theoretically. On the basis of beam-foil spectroscopy, the energies of nearly all the quintet levels belonging to the 2p(5)3s3p2 and 2p(5)3s3p4s configurations have been established, while only 5F levels from the 2p(5)3s3p3d configuration could be identified. Multiconfigurational Hartree-Fock calculations, inclu

Requirements Engineering with Use Cases - a Basis for Software Development

Successful development of software systems depends on the quality of the requirements engineering process. Use cases and scenarios are promising vehicles for eliciting, specifying and validating requirements. This thesis investigates the role of use case modelling in requirements engineering and its relation to system verification and validation. The thesis includes studies of concepts and represe

The mechanisms controlling heat and mass transfer on frying of beetburgers. I. The influence of the composition and comminution of meat raw material

Heat and mass transfer in minced meat patties (D = 100 mm, H = 10 mm) were studied during frying from the frozen state (-20 degreesC) to a Centre temperature of 72 degreesC in a double-sided pan fryer. The chemical composition of the meat raw material was varied to study the effect of the water, fat and connective tissue content and the water-protein ratio on the mass transfer (total loss. fat and

The matter of white matter in Alzheimer's disease. -On white matter disease from neuropathology and neuroimaging to clinical presentation.

Popular Abstract in Swedish Hjärnan består av hjärnbarken, även kallad den grå substansen, och den underliggande vita substansen. Den grå substansen med alla nervceller svarar bland annat för våra kognitiva funktioner som gör var och en av oss till unika individer. Medvetande, minne, språk och tal liksom ilska och glädje är alla exempel på egenskaper och funktioner som styrs från den grå substanseAlzheimer's disease (AD) is the most prevalent type of dementing disorder. The cortical pathology of AD has been recognized for almost a century. In later years, an associated pathological feature of AD has been identified which affects the white matter. This white matter disease (WMD), defined in the microscope, consists of a subtotal tissue loss of the white matter structural components. WMD is

Inhibition of the rise in FFA by Acipimox partially prevents GH-induced insulin resistance in GH-deficient adults

To test the hypothesis that GH-induced insulin resistance is mediated by an increase in FFA levels we assessed insulin sensitivity after inhibiting the increase in FFA by a nicotine acid derivative, Acipimox, in nine GH-deficient adults receiving GH replacement therapy. The patients received in a double blind fashion either Acipimox (500 mg) or placebo before a 2-h euglycemic (plasma glucose, 5.5

Diverse roles of cell-specific hypoxia-inducible factor 1 in cancer-associated hypercoagulation.

Despite the increased risk of thrombosis in cancer patients compared with healthy individuals, mechanisms that regulate cancer-induced hypercoagulation are incompletely understood. The aim of this study was to investigate whether cell-specific hypoxia-inducible factor (HIF) 1α regulates cancer-associated hypercoagulation, using in vitro clotting assays and in vivo cancer models. In mouse lung and