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Glial cell-line derived neurotrophic factor (GDNF) has demonstrated robust effects on dopamine (DA) neuron function and survival. A post-translational processing model of the human GDNF proprotein theorizes the formation of smaller, amidated peptide(s) from the proregion that exhibit neurobiological function, including an 11-amino-acid peptide named dopamine neuron stimulating peptide-11 (DNSP-11)

This article presents a water balance equation for predicting leachate generation in municipal solid waste (MSW) landfills located in semi-arid areas, using the Akaider landfill in Jordan as an example. HYDRUS-2D/3D software was used to model the effect of co-disposal of wastewater into the landfill on the leachate production rates and for comparison with the results of the simulation of the propo

The ATLAS experiment at the LHC has measured the Higgs boson couplings and mass, and searched for invisible Higgs boson decays, using multiple production and decay channels with up to 4.7 fb(-1) of pp collision data at root S = 7 TeV and 20.3 fb(-1) at root s = 8 TeV. In the current study, the measured production and decay rates of the observed Higgs boson in the gamma gamma, ZZ, WW, Z gamma, bb,

Inconspicuous consumption, the habitual use of resources in daily routines, poses a challenge to sustainable consumption. For example, laundry is often the most environmentally demanding stage of clothing’s life cycle, consuming significant quantities of water, energy and chemicals. Laundry thus provides a prime example of inconspicuous consumption, from which to consider sustainability transition

A total of 308,036 women were selected from the European Prospective Investigation into Cancer and Nutrition (EPIC) study to evaluate the association between tobacco smoking and the risk of cervical intraepithelial neoplasia of grade 3 (CIN3)/carcinoma in situ (CIS) and invasive cervical cancer (ICC). At baseline, participants completed a questionnaire and provided blood samples. During a mean fol

Helianthemum nummularium (L.) Mill. has two subspecies in southern Scandinavia, which differ in an indumentum character that is inherited as a Mendelian gene with two alleles. The dominant allele is the genetic basis for the key character of subsp. obscurum (absence of a dense felt of stellate hairs on the abaxial surface of the leaf), whereas the recessive allele is the genetic basis for the key

Electricity spot prices are characterized by sudden large movements, followed a few days later by an equally large movement in the opposite direction. These phenomena are called spikes (upward movements) and drops (downward movements). Recent research has suggested that the dynamics of the electricity spot prices can be accurately described by hidden Markov Regime Switching (MRS) models. Regime sw

Pollen and sediment stratigraphic analyses of a transect of core sequences are used to reconstruct Holocene lake-level changes in Lake Igelsjon, southern Sweden. The pattern of changes seen in the records is related to climatic/hydrological changes and agrees principally with the pattern characteristically found in lakes in southern Sweden. However, compared with an earlier study based on isotopic

OBJECTIVES: Rheumatoid arthritis (RA) is less common among men than women, and sex hormones have been suggested to play a part in the pathogenesis. Lower levels of testosterone have been demonstrated in men with RA, but it is not known if these changes precede the disease. METHODS: In a nested case-control study, using information and blood samples from a population-based health survey, we identif

We use a combination of simulations and a simple theoretical approach to investigate interactions between neutral conducting surfaces, immersed in an electrolyte solution. The study is conducted at the primitive model level, which necessitates the use of multiple image reflections. Our approximate theory is based on a classical density functional formulation of Poisson-Boltzmann theory. The same a

Haemophilus influenzae (Hi) causes respiratory tract infections and is also considered as a commensal, particularly in pre-school children. Tonsils from patients (n=617) undergoing tonsillectomy due to chronical infection or hypertrophy were examined. We found that 51 % of tonsils were positive for Hi, and in 95 % of cases analysed in detail (n=39) Hi resided intracellularly in the core tonsillar

Aortic stenosis (AS) shares risk factors with atherosclerotic vascular disease. Carotid intima-media thickness (IMT) and plaque may reflect the cumulative damage from exposure to different atherosclerotic risk factors. We examined the relationship of carotid IMT and plaque with incident AS in a prospective population-based study.

Motivation: The requirements engineering (RE) research community is aware of the importance of performing feasibility studies before starting requirements elicitation. Unfortunately, projects still frequently fail to achieve commercial success, responsibility is often unknown, and requirements engineers may be deemed responsible for mistakes made by others. Problem: There is neither empirical evid

Evidence is provided from studies on natural and artificial biofluids that the sequestration of amorphous calcium phosphate by peptides or proteins to form nanocluster complexes is of general importance in the control of physiological calcification. A naturally occurring mixture of osteopontin peptides was shown, by light and neutron scattering, to form calcium phosphate nanoclusters with a core-s

Objective: To investigate the hypothesis that cardiovascular risk factors increase the likelihood of future osteoarthritis (OA)-related arthroplasty in adult men and women. Methods: Baseline cohort data on cardiovascular risk factors [age, socio-economic class, family history, obesity, smoking, glucose, cholesterol, blood pressure, and early cardiovascular disease (CVD) history] were linked to cli

Objective. To compare results of obese patients with knee osteoarthritis (OA) who, after an intensive weight loss regimen, received 1 year of either dietary support (D), a knee-exercise program (E), or "no attention" (C; control group). Methods. We conducted a randomized, 2-phase, parallel-group trial. A total of 192 obese participants with knee OA were enrolled; the mean age was 62.5 years and 81

In speech and audio applications, short-term signal spectrum is often represented using mel-frequency cepstral coefficients (MFCCs) computed from a windowed discrete Fourier transform (DFT). Windowing reduces spectral leakage but variance of the spectrum estimate remains high. An elegant extension to windowed DFT is the so-called multitaper method which uses multiple time-domain windows (tapers) w

Fish waste is a potentially valuable resource from which high-value products can be obtained. Anaerobic digestion of the original fish waste and the fish sludge remaining after enzymatic pre-treatment to extract fish oil and fish protein hydrolysate was evaluated regarding the potential for methane production. The results showed high biodegradability of both fish sludge and fish waste, giving spec

Color patterns play central roles in the behavior of insects, and are important traits for taxonomic studies. Here we report striking and stable structural color patterns—wing interference patterns (WIPs) —in the transparent wings of small Hymenoptera and Diptera, patterns that have been largely overlooked by biologists. These extremely thin wings reflect vivid color patterns caused by thin film i