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Plasma MOTS-c levels are associated with insulin sensitivity in lean but not in obese individuals

Mitochondrial open reading frame of the 12S rRNA-c (MOTS-c) is a mitochondrial-derived peptide that attenuates weight gain and hyperinsulinemia when administered to high fat-fed mice. MOTS-c is therefore a potential regulator of metabolic homeostasis under conditions of high-energy supply. However, the effect of insulin resistance and obesity on plasma MOTS-c concentration in humans is unknown. To

Protamine neutralization of intravenous and subcutaneous low-molecular-weight heparin (tinzaparin, Logiparin(TM)). An experimental investigation in healthy volunteers

The aim of the present study was to investigate whether tinzaparin sodium (a low-molecular-weight heparin (LMWH)) was fully and permanently neutralized in vivo in man by protamine sulphate (PS) after intravenous (i.v.) or subcutaneous (s.c.) injection. Fifty healthy adults equally divided in five age- and sex-matched groups were included. The groups received 50 IU unfractionated heparin (UH)/kg bo

Antithrombotic effect of recombinant truncated tissue factor pathway inhibitor (TFPI1-161) in experimental venous thrombosis : A comparison with low molecular weight heparin

The aim was to investigate whether a truncated recombinant Tissue Factor Pathway Inhibitor (TFPI1-161) which lacked the third Kunitz-type domain and the basic c-terminal region, had an antithrombotic effect comparable to LMWH in a randomised double-dummy study. The experimental thrombosis was induced in jugular veins, in a total of 40 rabbits by a combination of destruction of the endothelium and

Temporal trend and regional disparity in osteoarthritis hospitalisations in Sweden 1998-2015

AIM: This study investigated time trend and regional disparities in hospitalisations due to osteoarthritis (OA) among people aged ≥20 years in Sweden from 1998 through 2015.METHODS: National and regional data on hospital admissions with a primary diagnosis of OA were collected from the National Patient Register. The absolute and relative regional disparities were assessed using the absolute weight

Liveness becomes Entelechy - A scheme for L6

Integrated development environments have provided increasingly powerful tools for software creation, and yet the creation of complex computer programs remains difficult and time-consuming. Liveness in a programming environment has been identified as one direction in which to pursue further improvements in programmer productivity. We propose a scheme for achieving strategically predictive liveness, t

Bandwidth and gain improvement of a crossed slot antenna with metasurface

A wideband metasurfaced (MS) slot antenna is proposed for circularly polarized (CP) operation. The antenna consists of a crossed slot antenna (CSA) and a MS placed at a short distance above the CSA. The CSA has two slots placed in orthogonal positions and with distributed elements to generate two E-fields with 90°-phase difference for CP radiation. A microstrip line is used to single feed the CSA

A Wideband Dual-polarized Inductor-end Slot Antenna with Stable-beamwidth

This letter presents a wideband cross-slot antenna (CSA) with inductor loadings for dual polarization. The effects of the ground size on the impedance are investigated. To achieve a compact size, a very small ground having the same hypotenuse length as the slot is used. The inductor loadings are used at both ends of the slot to reduce the size further. Simulated results show that the loaded induct

A Generalized Transition Matrix Model for Open-Ended Cavity With Complex Internal Structures

In this paper, a novel generalized transition matrix (GTM) algorithm is proposed to analyze the electromagnetic problems of open-ended cavity structures. An artificial reference surface is applied to seal the slots and/or apertures to reshape the target cavity into an interior domain (containing inner metallic surface and internal structures) and an exterior domain (containing the outer surface of