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Genome-wide association study identifies a common variant in RAD51B associated with male breast cancer risk

We conducted a genome-wide association study of male breast cancer comprising 823 cases and 2,795 controls of European ancestry, with validation in independent sample sets totaling 438 cases and 474 controls. A SNP in RAD51B at 14q24.1 was significantly associated with male breast cancer risk (P = 3.02 x 10(-13); odds ratio (OR) = 1.57). We also refine association at 16q12.1 to a SNP within TOX3 (

Quantitative serial imaging of an I-124 anti-CEA monoclonal antibody in tumor-bearing mice

Objective: The 4.2-day half-life I-124 favors its use for positron emission tomography (PET) of monoclonal antibodies (mAbs). However, high positron energy and beta(+)-associated cascade gamma rays pose image resolution and background noise problems for I-124. This study evaluated quantitative PET of an I-124 mAb in tumor-bearing mice. Methods: An R4 microPET (TM) (Siemens/CTIMI, Knoxville, TN) wa

Electron beam optics and trajectory control in the Fermi free electron laser delivery system

Electron beam optics (particle betatron motion) and trajectory (centroid secular motion) in the FERMI@Elettra free electron laser (FEL) are modeled and experimentally controlled by means of the ELEGANT particle tracking code. This powerful tool, well known to the accelerator community, is here for the first time fully integrated into the Tango-server based high level software of an FEL facility, t

The Pro12Ala polymorphism of the PPARG gene is not associated with the metabolic syndrome in an urban population of middle-aged Swedish individuals.

BACKGROUND: To determine if the common Pro12Ala polymorphism (rs1801282) of the peroxisome proliferator-activated receptor (PPARG) gene is associated with the metabolic syndrome (MetS) or with its individual components in middle-aged Swedish individuals. METHODS: MetS was defined according to the National Cholesterol Education Program/Adult Panel III (NCEP/ATP III), the International Diabetes Fede

Search for long-lived, multi-charged particles in pp collisions at root s=7 TeV using the ATLAS detector

A search for highly ionising, penetrating particles with electric charges from vertical bar q vertical bar = 2e to 6e is performed using the ATLAS detector at the CERN Large Hadron Collider. Proton-proton collision data taken at root s = 7 TeV during the 2011 running period, corresponding to an integrated luminosity of 4.4 fb(-1), are analysed. No signal candidates are observed, and 95% confidence

Invisible Lines Crossing the City: Ethnographic Strategies for Place-making

Helsingborg, a coastal city in southern Sweden, initiated a long-term redevelopment project called H+ in 2009, aiming to convert industrial harbor space in the city's south into a new, livable urban neighborhood and city center. The project aims to create an open and ‘tolerant city’ in Helsingborg over the next twenty years. In 2010-2011, H+ used an open-source planning method as a strategy to inc

Modeling Alien-Line Impedance Mismatch in Wideband Vectored Wireline Systems

Sudden changes of channel coefficients in a wideband vectored wireline system (such as G.fast) due to changes in the terminating impedance of lines outside the vectored group can seriously degrade stability and throughput. This letter presents a model that predicts the impact of termination mismatch based exclusively on crosstalk data for the properly-terminated state. Experimental results confirm

Multi-generational long-distance migration of insects: studying the painted lady butterfly in the Western Palaearctic

Long-range, seasonal migration is a widespread phenomenon among insects, allowing them to track and exploit abundant but ephemeral resources over vast geographical areas. However, the basic patterns of how species shift across multiple locations and seasons are unknown in most cases, even though migrant species comprise an important component of the temperate-zone biota. The painted lady butterfly

Människokunskap och långa tidsaxlar

Referring to historiographical tendencies and philosophical discourses on the use of history, the article presents a personal argument for the usefulness of the historian's craft today. Drawing on the research on violence, friendship, and silences in history, it would seem we need penetrating methods when examining the information and disinformation spread widely by the mass media and the Internet

Epithelial and Stromal MicroRNA Signatures of Columnar Cell Hyperplasia Linking Let-7c to Precancerous and Cancerous Breast Cancer Cell Proliferation.

Columnar cell hyperplasia (CCH) is the earliest histologically identifiable breast lesion linked to cancer progression and is characterized by increased proliferation, decreased apoptosis and elevated oestrogen receptor α (ERα) expression. The mechanisms underlying the initiation of these lesions have not been clarified but might involve early and fundamental changes in cancer progression. MiRNAs

Detection of a Spectral Break in the Extra Hard Component of GRB 090926A

We report on the observation of the bright, long gamma-ray burst, GRB 090926A, by the Gamma-ray Burst Monitor and Large Area Telescope (LAT) instruments on board the Fermi Gamma-ray Space Telescope. GRB 090926A shares several features with other bright LAT bursts. In particular, it clearly shows a short spike in the light curve that is present in all detectors that see the burst, and this in turn

Organic farming at local and landscape scales benefits plant diversity

Agri-environment schemes (AES) have been suggested to counter negative effects of agricultural intensification and enhance farmland biodiversity, but evaluations have produced inconsistent results. We suggest that this is partly a consequence of scale-dependence, i.e. that the consequence of organic farming will differ depending on the scale of uptake in a particular landscape. To test our hypothe

Robotic Work-Space Sensing and Control

Industrial robots are traditionally programmed using only the internal joint position sensors, in a sense leaving the robot blind and numb. Using external sensors, such as cameras and force sensors, allows the robot to detect the existence and position of objects in an unstructured environment, and to handle contact situations not possible using only position control. This thesis presents work on

PKC theta/beta and CYLD Are Antagonistic Partners in the NF kappa B and NFAT Transactivation Pathways in Primary Mouse CD3(+) T Lymphocytes

In T cells PKC theta mediates the activation of critical signals downstream of TCR/CD28 stimulation. We investigated the molecular mechanisms by which PKC theta regulates NF kappa B transactivation by examining PKC theta/beta single and double knockout mice and observed a redundant involvement of PKCh and PKC beta in this signaling pathway. Mechanistically, we define a PKC theta-CYLD protein compl