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Fibrotic disorders account for over one third of mortalities worldwide. Despite great efforts to study the cellular and molecular processes underlying fibrosis, there are currently few effective therapies. Dual-stage polymerization reactions are an innovative tool for recreating heterogeneous increases in extracellular matrix (ECM) modulus, a hallmark of fibrotic diseases in vivo. Here, we present

Dopamine receptor D1 modulates glutamatergic transmission in cortico-basal ganglia circuits and represents a major target of L-DOPA therapy in Parkinson’s disease. Here we show that D1 and metabotropic glutamate type 5 (mGlu5) receptors can form previously unknown heteromeric entities with distinctive functional properties. Interacting with Gq proteins, cell-surface D1-mGlu5 heteromers exacerbated

In recent years two Swedish companies, Telia and Lundin Petroleum, have had to work hard to legitimate their actions as a result of allegations of criminal activity. In this paper, the corporate framings employed to deal with allegations of crime will be analysed on the basis of Stanley Cohen's (2009) theoretical work on processes of denial and neutralization techniques. More specifically, the papIn recent years two Swedish companies, Telia and Lundin Petroleum, have had to work hard to legitimate their actions as a result of allegations of criminal activity. In this paper, the corporate framings employed to deal with allegations of crime will be analysed on the basis of Stanley Cohen's (2009) theoretical work on processes of denial and neutralization techniques. More specifically, the pap

BACKGROUND AND OBJECTIVE: Although value sets for the five-level version of the generic health-related quality-of-life instrument EQ-5D are emerging, there is still no value set available in the literature based on time trade-off valuations made by individuals experiencing the valued health states. The aim of this study was to estimate experience-based value sets for the EQ-5D-5L for Sweden using

This thesis deals with older persons on the move and their access to cross-border healthcare in the European Union. The number of persons crossing borders within the EU has increased exponentially in recent decades. Free movement has been at the core of the European integration project from its early days. Although it was originally intended to apply only to those who were economically active, theThis thesis deals with older persons on the move and their access to cross-border healthcare in the European Union. The number of persons crossing borders within the EU has increased exponentially in recent decades. Free movement has been at the core of the European integration project from its early days. Although it was originally intended to apply only to those who were economically active, the

Det är hög tid att ifrågasätta flygnormen och skapa nya förutsättningar och vanor kring resande som blir bestående, skriver Sara Ullström och Kimberly Nicholas vid LUCSUS, Lunds universitets centrum för studier av uthållig samhällsutveckling.

The telecommunication company Telia’s dealings in Uzbekistan have resulted in bribery accusations both in Sweden and in abroad. The article analyzes the defense mechanisms produced by both the corporation and the prosecuted former executives of the company. Telia’s initially denial eventually changed into a partial acknowledgment in combination with a scapegoating discourse. While Telia hardly def

Drought and scarcity of water resources require innovative and sustainable solutions to secure water availability for poor people. Choice of solar energy for desalination is a promising and sustainable cost-effective alternative for improving high quality water supply. Today, almost all Latin American countries use different desalination technologies except for Bolivia. Bolivia has an arid to semi

It is well understood that adding to the population increases CO2 emissions. At the same time, having children is a transformative experience, such that it might profoundly change adult (i.e., parents’) preferences and consumption. How it might change is, however, unknown. Depending on if becoming a parent makes a person “greener” or “browner,” parents may either balance or exacerbate the added COIt is well understood that adding to the population increases CO2 emissions. At the same time, having children is a transformative experience, such that it might profoundly change adult (i.e., parents') preferences and consumption. How it might change is, however, unknown. Depending on if becoming a parent makes a person "greener" or "browner," parents may either balance or exacerbate the added CO

We study the chemical evolution of Zr, La, Ce, and Eu in the Milky Way discs and bulge by means of chemical evolution models compared with spectroscopic data. We consider detailed chemical evolution models for the Galactic thick disc, thin disc, and bulge, which have been already tested to reproduce the observed [α/Fe] versus [Fe/H] diagrams and metallicity distribution functions for the three dif

A search for the direct production of the supersymmetric partners of τ-leptons (staus) in final states with two hadronically decaying τ-leptons is presented. The analysis uses a dataset of pp collisions corresponding to an integrated luminosity of 139 fb-1, recorded with the ATLAS detector at the Large Hadron Collider at a center-of-mass energy of 13 TeV. No significant deviation from the expected

This paper describes the measurements of flow harmonics v2-v6 in 3μb-1 of Xe+Xe collisions at sNN=5.44 TeV performed using the ATLAS detector at the Large Hadron Collider (LHC). Measurements of the centrality, multiplicity, and pT dependence of the vn obtained using two-particle correlations and the scalar product technique are presented. The measurements are also performed using a template-fit pr

Introduction: A new-born with congenital heart disease requires care that involves numerous specialists. Such care can be provided at tertiary referral hospitals and transportation is often needed. A crucial factor is the handover process, when the child is born at a distance, with transfer of both professional responsibility and continued care from one healthcare professional to another. Aim: The

Incommensurate order, in which two or more mismatched periodic patterns combine to make a long-range ordered yet aperiodic structure, is emerging as a general phenomenon impacting the crystal structures of compounds ranging from alloys and nominally simple salts to organic molecules and proteins. The origins of incommensurability in these systems are often unclear, but it is commonly associated wi

Purpose: To validate a new 2D-3D registration method of fusion imaging during aortic repair in a system prepared only for 3D-3D registration and to compare radiation doses and accuracy. Materials and Methods: The study involved 189 patients, including 94 patients (median age 70 years; 85 men) who underwent abdominal endovascular aneurysm repair (EVAR) with 2D-3D fusion on an Artis zee imaging syst

Background: About 20% of patients with colorectal cancer have liver metastases at the time of diagnosis, and surgical resection offers a chance for cure. The aim of the present study was to compare outcomes for patients that underwent simultaneous resection to those that underwent a staged procedure with the bowel-first (classical) strategy by using information from two national registries in Swed