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Enhanced cerebrovascular expression of matrix metalloproteinase-9 and tissue inhibitor of metalloproteinase-1 via the MEK/ERK pathway during cerebral ischemia in the rat.

BACKGROUND: Cerebral ischemia is usually characterized by a reduction in local blood flow and metabolism and by disruption of the blood-brain barrier in the infarct region. The formation of oedema and opening of the blood-brain barrier in stroke is associated with enhanced expression of metalloproteinase-9 (MMP-9) and tissue inhibitor of metalloproteinase-1 (TIMP-1). RESULTS: Here, we found an inf

Älskade ondska

Krönika om seriemördare i kriminaljournalistik och i populärkultur med anledning av fallet Thomas Quick

Human immunodeficiency virus type 1 biological variation and coreceptor use: from concept to clinical significance.

There is ample evidence for intra-patient evolution of the human immunodeficiency virus type 1 (HIV-1) biological phenotype during the pathogenic process. Evolution often involves switch of coreceptor use from CCR5 to CXCR4, but change to more flexible use of CCR5 occurs over time even in patients with maintained CCR5 use. The increasing use of entry inhibitors in the clinic, often specific for on

Incident management in urban transportation: application of data mining

Better understanding of the impacts of an incident may help analysts to design more appropriate incident management strategies. Very little is known to date about the usefulness of applying data mining in traffic and transport related research, although data mining has contributed its usefulness significantly in other fields. This research is intended to discover the relationship between motor veh

Children diagnosed with type 1 diabetes: a randomized controlled trial comparing hospital versus home-based care.

Aim: To compare two different regimens for children diagnosed with type 1 diabetes: hospital-based care or hospital-based home care (HBHC), referring to specialist care in a home-based setting. Method: The trial took place in Sweden with a randomized controlled design and included 60 children, aged 3-15 years. After 2-3 days with hospital-based care, children were randomized to either continue

Shaping the climate for language shift? English in Sweden's elite domains

This paper investigates how & to what degree English is used in specific elite domains in Sweden through analysis of (1) language requirements to participate in undergraduate & graduate programs at competitive institutions, & (2) language qualifications & language use patterns in elite professions. We find that English is used pervasively, but not exclusively. The paper also explor

A Note on Aeneid 6.893-8

One of the most puzzling passages of Vergil's Aeneid is the last lines of book VI where Aeneas and the Sibyl leave the underworld through the gate of ivory, the gate of false dreams. "Few passages of the Aeneid have given rise to more controversies and divergence of judgement" (Brooks Otis). In this article we analyse the linguistic context and propose a new solution to the problem.

Curve length, curve form, and location of lower-end vertebra as a means of identifying the type of scoliosis.

PURPOSE: To determine if the curve length, curve form, and location of the lower-end vertebra can identify the type of scoliosis. METHODS: Standing posteroanterior and lateral radiographs of 78 women and 27 men with scoliosis aged 8 to 32 years were retrospectively analysed. Parameters measured were (1) the curve length (the number of vertebrae in the main curve), (2) the curve form (C-form, inver

External losses in photoemission from strongly correlated quasi-two-dimensional solids

Expressions are derived for photoemission, which allow experimental electron energy loss data to be used for estimating losses in photoemission. The derivation builds on new results for dielectric response and mean free paths of strongly correlated systems of two-dimensional layers. Numerical evaluations are made for Bi2Sr2CaCu2O8 (Bi2212) by using a parametrized loss function. The mean free path

Symptomatic atherosclerosis is associated with an altered gut metagenome

Recent findings have implicated the gut microbiota as a contributor of metabolic diseases through the modulation of host metabolism and inflammation. Atherosclerosis is associated with lipid accumulation and inflammation in the arterial wall, and bacteria have been suggested as a causative agent of this disease. Here we use shotgun sequencing of the gut metagenome to demonstrate that the genus Col

A comparison of the Nottingham Health Profile and Short Form 36 Health Survey in patients with chronic lower limb ischaemia in a longitudinal perspective

BACKGROUND: Different generic quality of life instruments such as the Nottingham Health Profile (NHP) and the Short Form 36 Health Survey (SF-36) have revealed conflicting results in patients with chronic lower limb ischaemia in psychometric attributes in short-term evaluations. The aim of this study was to compare the NHP and the SF-36 regarding internal consistency reliability, validity, respons