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The BCR::ABL1 tyrosine kinase inhibitors (TKIs) in CML represent a paradigm for molecularly targeted therapy. However, clinical outcomes - rate/depth of response, treatment-free remission (TFR), progression to blast crisis (BC) - and adverse events vary among patients. While additional somatic mutations have been invoked to explain varying clinical outcomes, we here propose a complementary perspec

Oat grain is a traditional human food that is rich in dietary fibre and contributes to improved human health1,2. Interest in the crop has surged in recent years owing to its use as the basis for plant-based milk analogues3. Oat is an allohexaploid with a large, repeat-rich genome that was shaped by subgenome exchanges over evolutionary timescales4. In contrast to many other cereal species, genomic

Future-oriented environmental assessments—in particular, prospective life cycle assessments (LCAs)—are increasingly applied within the wastewater treatment (WWT) sector. This thesis contributes to this field of research by addressing how to estimate the environmental impact (improving LCA methodology) and what the impact amounts to (WWT-specific results) for a wastewater treatment plant not yet co

This article investigates trapping mechanisms in AlGaN/GaN high electron mobility transistors (HEMTs) at cryogenic temperatures (CTs) down to 4.2 K, using pulsed I–V and drain current transient spectroscopy (DCTS) measurements. The results revealed an overall increase of trapping effects at CT. In particular, a substantial increase in current collapse at low temperatures was observed and predomina

Introduction: Wildfires pose escalating risks to communities at the wildland--urban interface, often necessitating extensive evacuations. This thesis explores how driving behaviour during wildfire evacuations differs from routine conditions and how these differences can be modelled to improve traffic simulations, thereby supporting more informed planning and response decisions by authorities.Objec

We report the first observation of a momentum-resolved superconducting gap in the Hg-based trilayer cuprate, which holds the highest record of superconducting transition temperature (T_{c}) at ambient pressure. By angle-resolved photoemission spectroscopy utilizing a microfocused beam, clear quasiparticle dispersions originating from the inner and outer CuO_{2} planes (IP and OP, respectively) wer

Quantum instruments describe both the classical outcome and the updated state associated with a quantum measurement. We ask whether these processes can be simulated using only a natural subset of resources, namely projective measurements on the system and quantum processing of the postmeasurement states. We show that the simulability of instruments can be connected to an entanglement classificatio

Monoclinic β-Ga2O3 films grown on c-plane sapphire have been shown to exhibit six (201 ¯ )-oriented domains, which are equally spaced by rotation around the surface normal and equally sized by volume that render the film optical response effectively uniaxial. We derive and discuss an optical model suitable for ellipsometry data analysis of such films. We model mid- and far-infrared ellipsometry da

Huntington's disease (HD) is a fatal neurodegenerative disorder characterized by progressive motor, cognitive, and psychiatric symptoms. Research efforts to understand and treat the disease have historically focused on neuronal pathology, but growing evidence underscores the critical role of oligodendrocytes in its pathogenesis. This review synthesizes recent findings on oligodendroglial dysfuncti

III-Nitride high-electron mobility transistors (HEMTs) grown on AlN substrates offer significant advantages for high-power, high-frequency applications due to AlN high thermal conductivity and ultra-wide bandgap. However, achieving high-quality thin GaN channel layers on AlN is challenging because of lattice mismatch, which leads to columnar growth. In this work, we present the development of a tw

This thesis examines queer community archives (QCAs) and their governing documents in order to gain a better understanding of how they define themselves, their work, and the communities they serve. Focusing on archives associated with queer, leather, BDSM, and fetish communities, specifically The Queer Movement Archives and Library (QRAB) and the Leather Archives & Museum (LA&M), it examin

Among the most advanced techniques for quality control, image processing and optical methods areprominent because of their precision and versatility. These methods often involve analyzing specklesgenerated by coherent laser illumination because coherent light provides detailed and accuratemeasurement capabilities. In speckle metrology-based techniques, the accurate measurement ofspeckle displaceme

Pulmonary fibrosis remains a devastating and often fatal condition due to the lack of effective treatments that halt disease progression. Rodent models of pulmonary fibrosis are crucial to identify candidate targets and novel therapeutic agents. However, the attrition rate of novel drug candidates in clinical trials remains high. This review suggests complementing traditional methods used to evalu

Background: Drug-related problems are common in older individuals. A medication reconciliation has the goal of identifying and maintaining an accurate medication list and can serve to prevent drug-related problems caused by discrepancies. Objectives: This study aimed to explore primary care physicians’ intentions towards performing medication reconciliation in patients with multimorbidity using a

Over the last two decades, the social identity of the jihadist has become a central part of street culture. Depictions of jihadists can be found in popular music, movies and media reports. Propaganda celebrating or condemning jihadism circulates online, and a significant number of individuals with a background in street crime have flirted with or converted to jihadism. Drawing on ethnographic fiel

Bakgrund: Barn utsätts dagligen för smärtsamma procedurer inom barnsjukvården och obehandlad smärta kan leda till ökad smärtkänslighet i framtiden. Studier poängterar vikten av att nyttja evidensbaserade riktlinjer gällande multimodal smärtbehandling för att förebygga procedursmärta. Begränsat antal studier finns i Sverige om sjuksköterskans upplevelse av att arbeta utifrån riktlinjer vid smärtsam

Bakgrund: Andelen barn som ammas i Sverige minskar. För att gynna amning och de positiva hälsoeffekter både barn och moder erhåller genom amning är stöd från partnern centralt. Genom att öka kunskapen hos hälso- och sjukvårdspersonal kan stöd till modern anpassas. Syfte: Syftet var att belysa vilket stöd mödrar önskar få av sin partner under amningsperioden. Metod: En kvalitativ studiedesign med