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Quantitative landscape dynamics in Denmark through the last three millennia based on the landscape reconstruction algorithm approach

This paper explores the spatial and temporal land-cover variability within the main cultural landscape units in Denmark during the last 3,000 years. Quantitative estimates of the cover of trees, grasses, Cerealia and Calluna around nine Danish lakes were obtained using the recently developed Landscape Reconstruction Algorithm (LRA) (Sugita 2007a, b). The performance of the approach was evaluated b

Autumn orientation behaviour of paddyfield warblers, Acrocephalus agricola, from a recently expanded breeding range on the western Black Sea coast

The paddyfield warbler, Acrocephalus agricola, has extended its breeding range from Central Asia to the western Black Sea coast. The Balkan population offers a unique chance to test the effect of breeding range expansion on the genetically programmed migratory direction. We studied 21 paddyfield warblers at Durankulak Lake, NE Bulgaria, by recording their autumn migratory orientation in circular o

Using multilevel models to identify drivers of landscape genetic structure among management areas

Landscape genetics offers a powerful approach to understanding species’ dispersal patterns. However, a central obstacle is to account for ecological processes operating at multiple spatial scales, while keeping research outcomes applicable to conservation management. We address this challenge by applying a novel multilevel regression approach to model landscape drivers of genetic structure at both

Cardiovascular risk with androgen deprivation therapy for prostate cancer: Potential mechanisms.

Androgen deprivation therapy (ADT) is frequently used for the treatment of advanced prostate cancer. ADT is associated with numerous side effects related to its mode of action, namely the suppression of testosterone to castrate levels. Recently, several large retrospective studies have also reported an increased risk of diabetes and cardiovascular disease in men receiving ADT, although these risks

Lateral interactions in brush layers of bottle-brush polymers.

We used isotension-ensemble Monte Carlo simulations to study the properties of brush layers of bottle-brush polymers under lateral compression. The polymers were represented by a freely jointed hard-bead model with one side chain grafted to each bead of the main chain, and we considered variations in side-chain length and bead size. Brush properties, including brush height and surface pressure, we

Effect of pamidronate 30 mg versus 90 mg on physical function in patients with newly diagnosed multiple myeloma (Nordic Myeloma Study Group): a double-blind, randomised controlled trial

Background Compared with placebo, prophylactic treatment with bisphosphonates reduces risk of skeletal events in patients with multiple myeloma. However, because of toxicity associated with long-term bisphosphonate treatment, establishing the lowest effective dose is important. This study compared the effect of two doses of pamidronate on health-related quality of life and skeletal morbidity in pa

Non-invasive gas monitoring in newborn infants using diode laser absorption spectroscopy: A case study

Non-invasive diode laser spectroscopy was, for the first time, used to assess gas content in the intestines and the lungs of a new-born, 4 kg, baby. Two gases, water vapor and oxygen, were studied with two low-power tunable diode lasers, illuminating the surface skin tissue and detecting the diffusely emerging light a few centimeters away. The light, having penetrated into the tissue, had experien

On further enhancement of single-phase and flow boiling heat transfer in micro/minichannels

With fast growing power consumption and device miniaturization, micro/minichannels are superior to macrochannels or conventional channels for high heat-flux dissipation due to their large surface area to volume ratios and high heat transfer coefficients. However, the associated large pressure drop penalty and flow boiling instability of micro/minichannels hinder their advancement in many practical

A Simple Assessment of the Global Long Term Supply of the Rare Earth Elements by Using a System Dynamics Model

Our simple dynamic-simulation model shows that the global supply of Rare Earth Elements is limited for meeting the future demands of new technologies. Unless improved recycling policies are adapted strategic elements may become scarce in the next half-century as a result of a “peak Rare Earths Elements” phenomenon. The model results also show that the market alone cannot solve the resource-ineffic

Design of multimode multiband antennas for MIMO terminals using characteristic mode analysis

Characteristic mode analysis provides unparalleled insights into designing high performance multiple-input multiple-output (MIMO) terminal antennas at frequencies where the antenna elements are constrained to be electrically small. Conventionally, an electrically small single-antenna utilizes the fundamental characteristic mode of the terminal chassis to obtain sufficient bandwidth while maintaini

Virtual Blindness - A Choice Blindness Experiment with a Virtual Experimenter

How are people facing a virtual agent affected by the vividness and graphical fidelity of the agent and its environment? A choice blindness (CB) experiment - measuring detection rate of hidden manipulations - was conducted presenting a high versus low immersion virtual environment. The hypothesis was that the lower quality virtual environment (low immersion) would increase the detection rate for t

An automatic field sampler utilising supported liquid membrane (SLM) for on-site extraction of s-triazine herbicides and degradation products: applied to an agricultural region of Ethiopia

A portable and time-integrating field sampler based on the supported liquid membrane (SLM) extraction technique was constructed. Using two programmable syringe pumps and one programmable valve, the sampler could carry out automatic unattended extraction for up to seven extracts, combining the steps of sampling, trace enrichment and clean-up. The sampler was applied to the extraction of four s-tria

cAMP-elevation mediated by β-adrenergic stimulation inhibits salt-inducible kinase (SIK) 3 activity in adipocytes.

Salt-inducible kinase (SIK) 3 is a virtually unstudied, ubiquitously expressed serine/threonine kinase, belonging to the AMP-activated protein kinase (AMPK)-related family of kinases, all of which are regulated by LKB1 phosphorylation of a threonine residue in their activation (T)-loops. Findings in adrenal cells have revealed a role for cAMP in the regulation of SIK1, and recent findings suggest

Parkinson's Disease Case Ascertainment in the EPIC Cohort: The NeuroEPIC4PD Study

Background/Aims: Large epidemiological prospective studies represent an important opportunity for investigating risk factors for rare diseases such as Parkinson's disease (PD). Here we describe the procedures we used for ascertaining PD cases in the EPIC (European Prospective Investigation into Cancer and Nutrition) study. Methods: The following three-phase procedure was used: (1) elaboration of a

Investigation of the pH-Dependent Electron Transfer Mechanism of Ascomycetous Class II Cellobiose Dehydrogenases on Electrodes

Cellobiose dehydrogenase (CDH) is capable of direct electron transfer (DET) on various carbon and thiol-modified gold electrodes. As a result, these systems have been utilized as biocatalyst in biosensors and biofuel cell anodes. Class I CDHs, from basidiomycetous fungi, are highly specific to cellulose or lactose, and DET is only observed at pH values below 5.5. To extend the applicability of CDH

Crack tip transformation zones in austenitic stainless steel

Crack tip conditions in SUS 304 austenitic stainless steel are studied using a constitutive model in which the martensitic phase transformation is an integral part. The phase transformation occurring in the crack tip region gives rise to fracture toughening of the material whereby the resistance against crack initiation, as well as the macroscopic material response are strongly altered by the pres

Combined GW and dynamical mean-field theory: Dynamical screening effects in transition metal oxides

We present the first dynamical implementation of the combined GW and dynamical mean-field scheme ("GW + DMFT") for first-principles calculations of the electronic properties of correlated materials. The application to the ternary transition metal oxide SrVO3 demonstrates that this scheme inherits the virtues of its two parent theories: a good description of the local low-energy correlation physics

Meniscus pathology, osteoarthritis and the treatment controversy.

The menisci are internal structures that are of central importance for a healthy knee joint; they have a key role in the structural progression of knee osteoarthritis (OA), and the risk of the disease dramatically increases if they are damaged by injury or degenerative processes. Meniscus damage might be considered a signifying feature of incipient OA in middle-aged and elderly people. As approxim