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Differential induction of dyskinesia and neuroinflammation by pulsatile versus continuous l-DOPA delivery in the 6-OHDA model of Parkinson's disease

Neuroinflammation is associated with l-DOPA treatment in Parkinson's disease (PD), suggesting a role in l-DOPA-induced dyskinesia (LID), however it is unclear whether increased inflammation is specifically related to the dyskinetic outcome of l-DOPA treatment. Diversely from oral l-DOPA, continuous intrajejunal l-DOPA infusion is associated with very low dyskinetic outcome in PD patients. We repro

In vivo dopamine agonist properties of rotigotine : Role of D1 and D2 receptors

Rotigotine acts in vitro as a full agonist of dopamine D1 receptors at concentrations almost superimposable to those at which it acts on D2 receptors. However in vivo evidence of the differences between the agonist activity of rotigotine at D1 receptors from that on the D2 receptors has not been provided yet. In order to test the ability of rotigotine to stimulate dopamine D1 and D2 receptors in v

Withania somnifera Dunal (Indian ginseng) impairs acquisition and expression of ethanol-elicited conditioned place preference and conditioned place aversion

Withania somnifera Dunal (Indian Ginseng) has recently been shown to impair ethanol self-administration. In order to gain further insights on the ability of the Withania somnifera standardised root extract (WSE) to affect the motivational properties of ethanol, this study investigated whether WSE may also affect ethanol (2 g/kg)-elicited conditioned place preference (CPP) and aversion (CPA). To th

Strain dependence of adolescent Cannabis influence on heroin reward and mesolimbic dopamine transmission in adult Lewis and Fischer 344 rats

Adolescent Cannabis exposure has been hypothesized to act as a gateway to opiate abuse. In order to investigate the role of genetic background in cannabinoid-opiate interactions, we studied the effect of Δ(9) -tetrahydrocannabinol (THC) exposure of adolescent Lewis and Fischer 344 rats on the responsiveness of accumbens shell and core dopamine (DA), as monitored by microdialysis, to THC and heroin

Conditioned saccharin avoidance induced by infusion of amphetamine in the nucleus accumbens shell and morphine in the ventral tegmental area : Behavioral and biochemical study

Drugs of abuse possess the seemingly paradoxical property of conditioning rats to avoid from drinking a saccharin solution that had been predictively paired with their systemic administration (conditioned saccharin avoidance, CSA). CSA is dependent upon an intact dopamine (DA) transmission but the locus, central or peripheral, and eventually the brain area from which this effect originates and its

Logic filter cache for wide-VDD-range processors

Wide-VDD-range processors offer high energy efficiency for varying embedded workloads. But reducing the VDD of the cache as aggressively as the VDD of the CPU logic is not straightforward, since standard 6T SRAMs cease to operate at lower VDDs. We implement a data and instruction filter cache, using logic cells located in the CPU VDD domain, to permit the level-1 (L1) cache to be reliably powered

An LPC-based fronthaul compression scheme

Several new architectures are under investigation for cloud radio access networks, assuming distinct splits of functionality among the network elements. Consequently, the research on radio data compression for the fronthaul is based on assumptions that correspond to a wide variety of tradeoffs among data rate, signal distortion, latency, and computational cost. This letter describes a method for L

Determination of the neutron-capture rate of C 17 for r -process nucleosynthesis

With the RB3-LAND setup at GSI we have measured exclusive relative-energy spectra of the Coulomb dissociation of C18 at a projectile energy around 425A MeV on a lead target, which are needed to determine the radiative neutron-capture cross sections of C17 into the ground state of C18. Those data have been used to constrain theoretical calculations for transitions populating excited states in C18.

A transmission line model for co-designed slot-coupled dielectric resonator antennas

Co-design of monolithically-integrated millimetre-wave front-ends and antennas is alleviated by accurate device models. In this paper, a novel transmission line model for slotcoupled dielectric resonator antennas is proposed and verified. It describes distributed interaction between the coupling-structure and the radiating dielectric body of the antenna. This model thereby provides a simplistic an

Systematic nuclear structure studies using relativistic mean field theory in mass region A ∼ 130

Nuclear structure studies for even-even nuclei in the mass region ∼130, have been performed, with a special focus around N or Z = 64. On the onset of deformation and lying between two closed shell, these nuclei have attracted attention in a number of studies. A revisit to these experimentally accessible nuclei has been made via the relativistic mean field. The role of pairing and density depletion