Both environmental and host factors influence risk of cutaneous melanoma (CM), and worldwide, the incidence varies depending on constitutional determinants of skin type and pigmentation, latitude, and patterns of sun exposure. We performed genetic analysis of CDKN2A, CDK4, BAP1, MC1R, and MITFp.E318K in Danish high-risk melanoma cases and found CDKN2A germline mutations in 11.3% of CM families wit

Populärvetenskaplig artikel om bombningarna av Dresden i februari 1945.

The concept of society and its cognates have long been widely invoked in order to understand International Relations. Theories of international society distinguish between a society of states and a mere system of states, and theories of world society assume that the world constitutes a single social space. In order to come to terms with the social character of International Relations, constructivi

Nontypeable Haemophilus influenzae (NTHi) causes otitis media and is commonly found in patients with chronic obstructive pulmonary disease (COPD). Adhesins are important for bacterial attachment and colonization. Protein E (PE) is a recently characterized ubiquitous 16 kDa adhesin with vitronectin-binding capacity that results in increased survival in serum. In addition to PE, NTHi utilizes Haemop

The functionality of modern automotive vehicles is becoming increasingly dependent on control systems. Active safety is an area in which control systems play a pivotal role. Currently, rule-based control algorithms are widespread throughout the automotive industry. In order to improve performance and reduce development time, model-based methods may be employed. The primary contribution of this the

Background Polypharmacy in the Swedish elderly population is currently a prioritised area of research with a focus on reducing the use of potentially inappropriate medications (PIMs). Multi-professional interventions have previously been tested for their ability to improve drug therapy in frail elderly patients. Objective This study aimed to assess a structured model for pharmacist-led medication

Surfactin, a bacterial amphiphilic lipopeptide is attracting more and more attention in view of its bioactive properties which are in relation with its ability to interact with lipids of biological membranes. In this work, we investigated the effect of surfactin on membrane structure using model of membranes, vesicles as well as supported bilayers, presenting coexistence of fluid-disordered (DOPC)

Recent research has shown that agricultural management affects microbial biomass and community composition. We investigated the functional implications of such effects in terms of barley biomass production and nutrient acquisition, and whether changes in barley nutrient status affected aphid fecundity. Soils were collected from conventional, ley and organic arable fields and used as inocula in a g

BACKGROUND: There is an increasing interest in cognitive and functional outcomes in the respective stages of Alzheimer's disease (AD) and in novel therapies particularly for the milder phases of AD. Our aim was to describe and compare various aspects of disease progression in patients with mild versus moderate AD in routine clinical practice of cholinesterase inhibitor (ChEI) therapy. METHODS: Thi

The intestinal microbiota displays dramatic changes in the ICU patient, with a loss of the entire beneficial lactic bacterial flora. In situations of hyperinflammation followed by immune paresis that are due to the acute disease but also to chronic diseases and drugs used, it is crucial to reestablish inflammatory and immune homeostasis, and microbiota manipulations with probiotics or synbiotics i

Objective. Our aim was to investigate the effect of soy isoflavone (SI) on liver fibrosis in a thioacetamide (TAA)-induced rat model. Materials and methods. Twenty-eight rats were assigned to four groups: sham group, fibrosis group, low-dose treatment group (LDg) and high-dose treatment group (HDg). SI (90 or 270 mg/kg) was administered daily during the model development by TAA. Standard liver tes

The essence of the chemical mechanism for surface-enhanced resonance Raman scattering (SERRS) is the charge transfer (CT) between the metal and the molecule at the resonant electronic transition, which results in the mode-selective enhancement in the SERRS spectrum. The site-orientated CT can directly interpret the mode-selective chemical enhancement in SERRS. However, it is a great challenge to i

Predation is a major cause of breeding failure in bird species with open nests. Although many studies have investigated nest predation rates, direct identification of nest predators is sporadic, especially in (semi-)natural habitats. We quantified nest success and identified nest predators in a population of Skylarks Alauda arvensis and Woodlarks Lullula arborea breeding in a protected semi-natura

Enterprise resource planning (ERP) post-adoption stages (use and value) and small and medium enterprises (SME) are of high interest among both academics and practitioners. Grounded in the diffusion of innovation theory to explain ERP use and resource-based view theory to explain ERP value the authors postulate that use is an important link to value. The authors propose and test a model using a uni

Objective: To investigate (i) the performance and agreement between various activity indices and response criteria in TNF-blockade of RA; (ii) the predictive ability of different response criteria and disease activity states regarding continuation of anti-TNF treatment of RA; (iii) Euro-QoL-5-dimensions utility development during TNF blockade of RA, PsA and SpA. Also, (iv) to develop a simple, uti

During the last decades there has been an upsurge in research on xenophobic populist parties, mirroring their political successes. In the Swedish context, characterised by neoliberal restructuring, issues of race', citizenship and belonging have been important elements of the public debate. These issues have unfolded in parallel with the presence of a neo-Nazi social movement and the emergence of

Popular Abstract in Swedish Kroppens immunförsvar brukar delas in i det medfödda och det adaptiva immunförsvaret. Det medfödda immunförsvaret reagerar snabbt på yttre hot såsom bakterier. Olika sorters vita blodkroppar är väldigt viktiga för detta snabba svar på infektion och i min avhandling har jag koncentrerat mig på en av dessa; neutrofilen. Neutrofilen är den vita blodkropp som först komNeutrophil elastase (NE) has important roles in innate immunity, killing pathogens and controlling the immune response; but how NE is targeted to developing granules is not understood. Therefore, the aim of this thesis was to investigate the sorting of NE. Transfection experiments in a leukemic cell line, which were confirmed in normal hematopoietic cells, showed that a population of proNE was ta