The development and transplantation of autologous cells derived from nuclear transfer embryonic stem cell (NT-ESC) lines to treat patients suffering from disease has been termed therapeutic cloning. Human NT is still a developing field, with further research required to improve somatic cell NT and human embryonic stem cell differentiation to deliver safe and effective cell replacement therapies. F

Decision-making in risk management reflects a normative choice of approach. This dissertation is concerned with the possibility of putting the decision in focus by employing an optimum decision criterion within a utility-based approach. The dissertation describes a cost-benefit analysis of separation distance, a risk-reducing measure used in land use planning in the vicinity of hazardous installat

This paper argues that the main contribution of Mirowski's paper is the new combination of some seemingly unrelated ideas, like principles for market evolvement and automata theory. Furthermore, many of Mirowski's ideas ought to be inspiring for future economic research. However, it is argued that some ideas, if scrutinized, are difficult to motivate, and other need further refinement before they

Secretagogin is a hexa EF-hand protein, which has been identified as a novel potential tumour marker. In the present study, we show that secretagogin binds four Ca2+ ions (log K-1 = 7.1 +/- 0.4, log K-2 = 4.7 +/- 0.6, log K-3 = 3.6 +/- 0.7 and log K-4 = 4.6 +/- 0.6 in physiological salt buffers) with a [Ca2+](0.5) of approx. 25 mu M. The tertiary structure of secretagogin changes significantly upo

Genetic and environmental factors contribute to age-dependent susceptibility to type 2 diabetes. Recent studies have reported reduced expression of PPAR{gamma} coactivator 1{alpha} (PGC-1{alpha}) and PGC-1ß genes in skeletal muscle from type 2 diabetic patients, but it is not known whether this is an inherited or acquired defect. To address this question we studied expression of these genes in mus

To determine the functions of fibromodulin (Fmod), a small leucine-rich keratan sulfate proteoglycan in tooth formation, we investigated the distribution of Fmod in dental tissues by immunohistochemistry and characterized the dental phenotype of 1-day-old Fmod-deficient mice using light and transmission electron microscopy. Immunohistochemistry was also used to compare the relative protein express

This thesis presents experimental investigations of local heat transfer and detailed flow measurements in ribbed rectangular ducts and impinging jets. The advanced measurement methods, Liquid Crystal Thermography (LCT) and Particle Image Velocimetry (PIV) are adopted to provide full field characteristics. The work consists of two parts, regarding rib-roughened rectangular ducts and impinging slot

Various factors influencing affinity partitioning in aqueous polymer two-phase systems are studied by model calculations using a self-consistent mean-field lattice theory. The latter is an extension of the theory of Scheutjens and Fleer, adapted to take affinity ligand binding into account. The dependence of partition coefficients on ligand concentration is studied for different binding strengths,

Excited states in the proton emitter Sb-105 have been investigated for the first time. The nucleus was populated in the reaction Cr-50(Ni-58,1p2n). The GAMMASPHERE Ge-detector array was used together with Microball and the Neutron Shell for selection of the reaction channel. The experimental level scheme agrees well with results of a shell model calculation that uses realistic effective interactio

Popular Abstract in Swedish Denna avhandling inom forskarutbildningsämnet arbetsmiljöteknik beskriver nyutvecklade provtagnings- och analysmetoder för att undersöka hur reaktionsbenägna luftföroreningar uppkommer och sprids i arbetsmiljön. Antalet människor som drabbas av allergier har ökat de senaste årtiondena. Många av de mekanismer som ger upphov till allergier och överkänslighetsreaktioner kMany sources of airborne contaminants have always been present in various work environments. With the development of thermosetting plastic systems, the use of reactive chemical compounds was greatly increased and thus also the risk of exposure to reactive and potentially hazardous compounds. Exposure can occur in many situations, not only at the workplace where the raw materials are handled. The f

Swedish agriculture is currently undergoing radical changes with respect to the working environment. New production milking systems may alter the physical workload and thus have an effect on the development of musculoskeletal disorders. Earlier studies have shown that there is a manifest risk of suffering injury to the forearm, wrist and hand during machine milking especially during the attaching

Caspase activation and degradation of deoxyribonucleic acid (DNA) damage response factors occur during in vitro T-cell proliferation, and an increased frequency of hypoxanthine-guanine phosphoribosyltransferase (HPRT)-negative variants have been reported in conditions associated with in vivo T-cell proliferation. We have applied two human somatic cell mutation reporter assays, for the HPRT and pho

A new halogen-specific detection method (XSD) was tested for determination of chlorinated fatty acids in marine biota. In XSD, an increased emission of ions and electrons is caused by the high-temperature combustion of halogen-containing compounds. The detection limit of methyl dichlorooctadecanoate and the selectivity at a reactor temperature of 900 degreesC match those of electrolytic conductivi

Selective pressurized liquid extraction (PLE) of polychlorinated dibenzo-p-dioxins/dibenzofurans (PCDD/Fs) and dioxin-like polychlorinated biphenyls (dl-PCBs) from various food and feed samples was performed with a selective PLE method previously developed for bulk PCBs. The method utilizes sulfuric acid impregnated silica inside the extraction cell to oxidize coextracted fat. Extractions were per

Objectives. The primary objective was to demonstrate equivalence between a.m. and p.m. dosing of celecoxib 200 mg q.d. An equivalence assessment of q.d. vs b.i.d. dosing was a secondary objective. Methods. In this randomized, double-blind study, patients with symptomatic osteoarthritis of the knee or hip were randomized to receive celecoxib 200 mg q.d. a.m., celecoxib 200 mg q.d. p.m. or celecoxib

The flux of an ion in an ionic solution is due to a concentration gradient and an electrical potential gradient. The latter is a result of differences in the diffusion constants of the diffusing ions. Even though it is possible to express the electrical potential gradient in terms of concentrations and concentration gradients, it results in a complicated system to solve if more than two species di