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BACKGROUND: Individuals with autism spectrum disorder (ASD) have an increased risk of developing epilepsy. Both ASD and epilepsy have been associated with increased levels of immune factors in the blood, including the proinflammatory cytokine interleukin 6 (IL-6). Mice lacking the synapsin 2 gene (Syn2 KO) exhibit ASD-like behavior and develop epileptic seizures. Their brains display neuroinflamma

During epileptic seizures, neuronal network activity is hyper synchronized whereby GABAergic parvalbumin-interneurons may have a key role. Previous studies have mostly utilized 4-aminopyridine to induce epileptiform discharges in brain slices from healthy animals. However, it is not clear if the seizure-triggering ability of parvalbumin-interneurons also holds true without the use of external conv

Significant collaborations with research partners in China are seen in many Western countries. With increasing geopolitical tensions governments, research institutions and individuals are increasingly called upon to address a proliferating array of risks and challenges associated with scientific collaboration with China. The situation is characterised by two parallel, intertwined processes. On the

Conformational changes and stability of interacting double-stranded DNA chains under high hydrostatic pressure in biological systems are striking topics of importance to study several biomolecular phenomena. For example, to unravel the physiological conditions at which life might occur and to ensure the right functionality of the biochemical processes into the cell under extreme thermodynamic cond

Widespread contamination of ecosystems with pesticides threatens non-target organisms. However, the extent to which life-history traits affect pesticide exposure and resulting risk in different landscape contexts remains poorly understood. We address this for bees across an agricultural land-use gradient based on pesticide assays of pollen and nectar collected by Apis mellifera, Bombus terrestris

This chapter illuminates what nurses experience as central conflicts shaping their everyday/everynight work, and what forms of injustice they identify as arising from those circumstances. Through the concept of real utopia, we explore what forms of radical visions of care nurses harbour and express. A central argument is that the interviewed nurses suggest a new system of value - in which care con

Automated soil moisture systems are commonly used in precision agriculture. Using low-cost sensors, the spatial extension can be maximized, but the accuracy might be reduced. In this paper, we address the trade-off between cost and accuracy comparing low-cost and commercial soil moisture sensors. The analysis is based on the capacitive sensor SKU:SEN0193 tested under lab and field conditions. In a

Hedvig Eleonora (1636-1715), barockens drottning, gift med Karl X Gustav, mor till Karl XI och farmor till Karl XII. Mecenat för konst och kultur, medlem i två förmyndarregeringar. Skildring av 1600-talets Sverige, stormaktens uppgång och fall.

Purpose: To explore pressure-related effects in the adult porcine retina in vitro. Methods: Retinal explants were subjected to 0, 10, 30, or 60 mmHg of pressure for 24 or 48 hours in culture. Overall tissue damage in sections was assessed by lactate dehydrogenase media levels, hematoxylin and eosin staining, and TUNEL staining. Inner retinal neurons were evaluated by protein kinase C alpha (rod bi

OBJECTIVES: To estimate the incidence of non-vertebral fractures in ankylosing spondylitis (AS) compared with the general population. METHODS: Nationwide register-based cohort study including patients with AS (n=11 611, 65% men, mean age 48 years), and matched general population controls (n=58 050). Five prespecified fracture outcomes: (1) non-vertebral; (2) fracture of the proximal humerus, dista

Network-based biocomputation (NBC) relies on accurate guiding of biological agents through nanofabricated channels produced by lithographic patterning techniques. Here, we report on the large-scale, wafer-level fabrication of optimized microfluidic channel networks (NBC networks) using electron-beam lithography as the central method. To confirm the functionality of these NBC networks, we solve an

When creating models of a system, there is always a tradeoff between the ease of modelling a part and the increased value it brings to the model. Learning a model using machine learning instead, we are able to capture all kinds of things we don't necessarily understand, but can need large amounts of data to learn even the things we find simple. Using universal differential equations we can combine