Approximately 5-10 % of all melanoma patients have close relatives with melanoma. 5-20% of melanoma families have germline mutations in the CDKN2A gene. Swedish CDKN2A mutation carriers have a young median age of onset of melanoma, increased risks of multiple primary melanoma and of tobacco-associated cancers in respiratory and upper digestive tissues, and also worse survival compared to non-carri

Aims: To examine whether genetic influences on the development of alcohol use disorders (AUD) among men during emerging adulthood through mid-adulthood are stable or dynamic. Design: A twin study modeling developmental changes in the genetic and environmental influences on AUD during three age periods (18-25, 26-33 and 33-41) as a Cholesky decomposition. Setting: Sweden. Participants: Swedish male

Anaplastic large cell lymphomas (ALCLs) are rare CD30+ peripheral T-cell lymphomas (PTCLs) classified according to the expression of the anaplastic lymphoma kinase (ALK+) protein or not (ALK-). We have analysed the outcome and risk factors for survival in a population-based bi-national cohort of patients with systemic ALK+ ALCL. A total of 122 adult (≥18 years) patients diagnosed with ALK+ ALCL be

Purpose. To test whether Müller glial cells sense, and respond to, mechanical tension in the retina. Methods. A device was designed to stretch the retina at right angles to its surface, across retinal layers. Pieces of retina were mounted between two hollow tubes, and uniaxial force was applied to the tissue using a micrometer-stepping motor. Müller cells were selectively stained with the fluoresc

En antologi om politisk ekologi innehållandes tretton kapitel författade av olika forskare inom fältet. Tre av dessa kapitel är översatta äldre texter.

This article analyses new waves of cultural production in the late Soviet and post-Soviet period. It focuses on contemporary artists’ self-perception and self-positioning in the new realities of the postsocialist cultural realm and national awakening discourses. Independent contemporary artists of the post-Soviet period form new artistic movements, such as Punk Shamanism in Kazakhstan, to produce

I have a returning nightmare: my computer breaks down and I am losing all my written words. Losing the record I keep of my stories. The trails of where I have been in my thoughts dissolve and I am left empty. ”Stories matter. Many stories matter”, writer Chimamanda Ngozi Adichie reminds us in her famous TED-talk on ’the danger of a single story’ (Adichie 2009). Telling stories from my research on

Structural analysis of biological membranes is important for understanding cell and subcellular organelle function as well as their interaction with the surrounding environment. Imaging of whole cells in three dimension at high spatial resolution remains a significant challenge, particularly for thick cells. Cryo-transmission soft X-ray microscopy (cryo-TXM) has recently gained popularity to image

Pancreatic cancers are associated with poor survival and only some 10 per cent are resectable, but even in this subgroup recurrence is very frequent. The traditional view of sequential development of pancreatic cancer has been challenged by novel molecular biological findings, where the tumor quite rapidly might turn metastatic. In about 60 000 patients with diagnosed pancreatic cancer the associa

Collaboration between modellers and experimentalists is essential in ecological research, however, different obstacles linking both camps often hinder scientific progress. In this commentary, we discuss several issues of the current state of affairs in this research loop. Backed by an online survey amongst fellow ecologists, modellers and experimentalists alike, we identify two major areas that ne

Background: There is a need for a prehospital stroke test that in addition to high sensitivity for stroke, also is able to communicate stroke severity similar to the National Institute of Health Stroke Scale (NIHSS). Methods: The PreHospital Ambulance Stroke Test (PreHAST), an eight item test based on NIHSS, which scores stroke severity from 0-19 points, was designed and adapted for the ambulance

Background: Practice guidelines for childhood posttraumatic stress disorder (PTSD) recommend trauma-focused psychotherapies, mainly cognitive behavioral therapy (CBT). Eye movement desensitization and reprocessing (EMDR) therapy is a brief trauma-focused, evidence-based treatment for PTSD in adults, but with few well-designed trials involving children and adolescents. Methods: Weconducted a single

The tumor microenvironment can act so as to stimulate or reject tumor cells. Among the determining factors are cytokines produced, for example, by infiltrating immune cells, tumor cells, and fibroblasts. External radiotherapy has been shown to be able to activate an immune response against tumor cells with cytokine signaling as an important part of the activation. The aim of this study was to eval

A collection of essays translated by Étienne Dobenesque.

Transport is a significant and growing contributor to climate change. To stay within ‘safe’ global warming guardrails requires substantial cuts in greenhouse gas emissions. This represents a global political consensus, but there is evidence that current legislation in the transport sector is not significant enough to achieve medium- and longer-term reduction goals. In focusing on the European Unio