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Inter- and intramolecular potential for the N-formylglycinamide-water system. A comparison between theoretical modeling and empirical force fields

An intramolecular NEMO potential is presented for the N-formylglycinamide molecule together with an intermolecular potential for the N-formylglycinamide-water system. The intramolecular N-formylglycinamide potential can be used as a building block for the backbone of polypeptides and proteins. Two intramolecular minima have been obtained. One, denoted as C5, is stabilized by a hydrogen bonded five

The 39-item Parkinson's disease questionnaire (PDQ-39) revisited: implications for evidence-based medicine.

Background: The 39 item Parkinson's disease questionnaire (PDQ-39) is the most widely used patient reported rating scale in Parkinson's disease. However, several fundamental measurement assumptions necessary for confident use and interpretation of the eight PDQ-39 scales have not been fully addressed. Methods: Postal survey PDQ-39 data from 202 people with Parkinson's disease (54% men; mean age 70

Kin competition and the evolution of dispersal in an individual-based model

The evolution of dispersal was investigated in an adaptive individual-based metapopulation model, which allowed for demographic and environmental stochasticity. The individual dispersal behaviour was determined by a one-locus genotype subjected to simple inheritance and mutation. Dispersal behaviour could therefore evolve through the genotype–phenotype mapping and the selection regimes stemming fr

Expression and biological role of laminin-1.

Of the approximately 15 laminin trimers described in mammals, laminin-1 expression seems to be largely limited to epithelial basement membranes. It appears early during epithelial morphogenesis in most tissues of the embryo, and remains present as a major epithelial laminin in some adult tissues. Previous organ culture studies with embryonic tissues have suggested that laminin-1 is important for e

Augmentation mammaplasty--psychiatric and psychosocial characteristics and outcome in a group of Swedish women

Thirty-eight women undergoing augmentation mammaplasty, consecutively operated on at the Department of Plastic and Reconstructive Surgery, Malmo, Sweden, were studied preoperatively regarding medical history, personality, psychosocial and psychiatric characteristics. Thirty-six of these patients were interviewed one year postoperatively. Thirty-three age-matched women operated on with minor surgic

Human immunodeficiency virus type 1 vectors with alphavirus envelope glycoproteins produced from stable packaging cells

Alphavirus glycoproteins have broad host ranges. Human immunodeficiency virus type 1 (HIV-1) vectors pseudotyped with their glycoproteins could extend the range of tissues that can be transduced in both humans and animal models. Here, we established stable producer cell lines for HIV vectors pseudotyped with alphavirus Ross River virus (RRV) and Semliki Forest virus (SFV) glycoproteins E2E1. RRV E

Autoantibodies to autonomic nerves associated with cardiac and peripheral autonomic neuropathy.

OBJECTIVE—This study examines whether autonomic nerve autoantibodies (ANabs) are associated with development of autonomic neuropathy using a prospective study design. RESEARCH DESIGN AND METHODS—A group of type 1 diabetic patients were followed prospectively with regard to autonomic nerve function on four occasions. At the third examination, 41 patients were tested for ANabs (complement-fixing au

Experimental Studies of Separated Flow and Heat Transfer in a Ribbed Channel

The main concern of this thesis is to experimentally investigate the turbulent flow and heat transfer in a ribbed channel. Such flows are encountered in many engineering applications, e.g., gas turbine cooling. In order to highlight the physical mechanism of flow separation, only one wall of the channel is fitted with periodic ribs. The inter-rib spacing is set such that the reattachment is allowe

Adaptive Blood Velocity Estimation in Medical Ultrasound

This paper investigates the use of data-adaptive spectral estimation techniques for blood velocity estimation in medical ultrasound. Current commercial systems are based on the averaged periodogram, which requires a large observation window to give sufficient spectral resolution. Herein, we propose a novel data-adaptive method to form the blood velocity spectral estimate. The method is evaluated u

Nordic Reference Interval Project Bio-bank and Database (NOBIDA): a source for future estimation and retrospective evaluation of reference intervals

In the Nordic Reference Interval Project 2000 (NORIP) serum, Li-heparin plasma and EDTA buffy coat were collected at 102 laboratories in 5 Nordic countries from healthy individuals aged 18 years or more and evenly distributed for laboratory, gender and age. Multiple aliquots of these samples from each of about 3000 persons are now stored at the Nordic Reference Interval Project Bio-bank and Databa

Antenna signal correlation and its relation to the impedance matrix

Theory is presented that extends the analysis to signal correlation between any antennas in an array of elements. It is generalised to include non-identical elements and arbitrary load termination of passive antenna ports. The method is related to the power balance concept and based on the antenna impedance matrix.

Remote imaging laser-induced breakdown spectroscopy and remote cultural heritage ablative cleaning

We report, for what we believe to be the first time, on remote imaging laser-induced breakdown spectroscopy (LIBS). Measurements have been performed by using a tripled Nd:YAG laser working at 355 nm with 170 mJ pulse energy, with an expanded beam that is focused onto a target at 60 m distance. The LIBS signal is detected by using an on-axis Newtonian telescope and an optical multichannel analyzer.

Interstitial laser coagulation versus transurethral resection of the prostate for benign prostatic enlargement - A prospective Randomized study

Objective: Interstitial laser coagulation (ILC) of the prostate is a minimally invasive method for treating symptomatic benign prostatic enlargement (BPE). We performed a prospective randomized study to compare the clinical outcomes of ILC and transurethral resection of the prostate (TURP). Material and Methods: Between December 1997 and February 2000, 38 patients with moderate-to-severe symptomat