This thesis describes a combinatorial approach to design and synthesis of three libraries of compounds, referred to as pilicides, designed to target periplasmic chaperones present in uropathogenic Escherichia coli bacteria that are the main cause of urinary tract infections. Periplasmic chaperones are required for assembly of adhesive organelles, i.e. pili, which recognize and bind to specific rec

The period from 1910 to 1930 was a time when a number of theoretical systems saw the light of the day in Central Europe: psychoanalysis, neopositivism, phenomenology, the Warsaw School of logic, Gestalt-psychology and the structuralism of the Prague School of Linguistics. The Prague School arose in the liberal-minded Prague of the 1920s and came to have an enormous influence on multiple fields wit

A Low Weber water spray subjected to an air cross flow has been investigated. The spray is characterized by low liquid injection velocity, producing a column that is broken up by aerodynamic forces from the oncoming air.PIV and PDA have been used to quantify both the continuous and dispersed phases. Long range microscopy has been used to characterize the column breakup process. It has been shown t

Hur kan man leda och organisera granskning för att säkra oberoende och kvalitet? Hur ska oberoendet regleras och organiseras, och vad betyder kultur och ledarskap? I boken utvecklas ett ramverk för att förstå dessa frågor. Vidare diskuteras betydelsen av olika vägval avseende granskningsinriktning och externa relationer. Boken utgår från fallet Riksrevisionen och dess vägval under de första tio å

Radionuclide therapy (RNT), is important for the treatment of certain benign and malignant diseases. 90Y-Zevalin™ therapy has become an established method of treating patients with non-Hodgkin B-cell lymphoma. Several observ¬ations regarding the outcome of therapy have prompted the use of higher absorbed doses by administering larger amounts of activity than those indicated in standard protocols.

Rapporten beskriver förekomst och orsaker av nyodling i Sverige under 2000-talet utifrån ett antal gårdsfall där enskilda skiften nyodlats och två års statistik över skogsavverkning med ändamålet att föra över skogsmark till jordbruksmark. Statistiken diskuteras på nationell, läns- och kommunnivåer och jämförelser görs av nyodlingsarealen med befintliga arealer jordbruks- och skogsmark liksom av a

Abstract is not available

Recently, new cycles for power generation, such as wet cycles and cycles for CO2 capture, have gained increasing interest. These new cycles use some sort of dilution in the air/fuel mixture, e.g. steam or CO2. Gas turbine cycles using LCV gases can also be said to fit this description. Almost all modern gas turbines use a lean premixed combustion system, since it combines low NOX emissions with hi

We study quantization noise modeling in a low-delay vector predictive transform coder for speech signals. The coder uses a Kalman filter with a backward estimated LPC model of the speech signal combined with an additive noise model of the quantization noise. Computer simulations indicate that modeling of the quantization noise can improve the quality of the decoded speech signal. This is especiall

Abstract in UndeterminedSwedish and French avoid placing focused constituents at the left periphery of sentences. This has previously been suggested to be due to phonological factors. Here, we develop this idea and argue that the reason for avoiding focus at the left edge in these languages is the existence of syntactically related prosodic prominences in the beginning of utterances. Initial focal