Sökresultat

Microphthalmia-associated transcription factor (MITF) is a master regulator of melanocyte development and an important oncogene in melanoma. MITF heterodimeric assembly with related basic helix-loop-helix leucine zipper transcription factors is highly restricted, and its binding profile to cognate DNA sequences is distinct. Here, we determined the crystal structure of MITF in its apo conformation

Motor complications impair quality of life and cause severe disability in patients with advanced Parkinson's disease (PD). Since they are often refractory to medical therapy, interventional therapies have been developed, which can provide a considerable reduction of daily off-time and dopaminergic dyskinesias. Continuous dopaminergic drug delivery (CDD) is based on the steady stimulation of striat

BACKGROUND: Knee rotation plays an important part in knee kinematics during weight-bearing activities. An external device for measuring knee rotation (the Rottometer) has previously been evaluated for validity by simultaneous measurements of skeletal movements with Roentgen Stereometric Analysis (RSA). The aim of this study was to investigate the reliability of the device. METHOD: The within-day

We propose a methodology based on multivariate extreme value theory, to analyze the dependence between markets during the financial crisis. We argue that extreme dependence based on block maximum is a more appropriate measure to study dependence between stock markets, when a regime shifts, than other alternatives. With this methodology, we are able to detect the increase in the extreme dependences

Gm-C filters suffer from limited dynamic range due to a trade-off between noise and linearity in OTA design. This paper therefore presents a filter with a linearization technique to break this trade-off. This technique is demonstrated by a low power 4th order 10MHz Butterworth Gm-C low pass filter. The filter was implemented in 65nm CMOS technology with a core area of 0.19mm2 and a total current c

The formation of planets depends on the underlying protoplanetary disc structure, which in turn influences both the accretion and migration rates of embedded planets. The disc itself evolves on time scales of several Myr, during which both temperature and density profiles change as matter accretes onto the central star. Here we used a detailed model of an evolving disc to determine the growth of p

Compared with the effect of invaders on the native terrestrial fauna of New Zealand, interactions between native fishes and introduced trout (sports fish in the genera Salmo, Oncorhynchus and Salvelinus) are less well known and there have been fewer efforts to remedy their effects. Trout have caused widespread reductions in the distribution and abundance of native galaxiid fishes, a family dominat

Artikel om dans i privata salonger under förra delen av 1800-talet i Sverige.

Excited states in the N = 88 nucleus Tb-153 were observed up to spin similar to 40 in an experiment utilizing the Gammasphere array. The Tb-153 states were populated in a weak alpha 4n evaporation channel of the Cl-37 + Sn-124 reaction. Two previously known sequences were extended to higher spins, and a new decoupled structure was identified. The pi h(11/2) band was observed in the spin region whe

The issue of the rationale for public intervention under the system of innovation (SI) perspective has recently received increasing attention from scholars and practitioners. However, with few exceptions, this literature has been based on the analysis of innovation policies and innovation systems in industrialized countries neglecting almost completely the specific policy dilemmas that arise from

In this study, a novel method of preparation of cryogels based on oxidised dextran (Ox.D) and gelatin (Gel) without sodium borohydride is proposed. The physico-chemical properties of obtained hydrogels were investigated. It was found that the stability of cryogels Ox.D-Gel is significantly depended on pH, and mechanical properties were improved after the freeze drying. The schemes of the reactions

Intraneuronal inclusions containing alpha-synuclein (a-syn) constitute one of the pathological hallmarks of Parkinson's disease (PD) and are accompanied by severe neurodegeneration of A9 dopaminergic neurons located in the substantia nigra. Although to a lesser extent, A10 dopaminergic neurons are also affected. Neurodegeneration of other neuronal populations, such as the cholinergic, serotonergic

We have studied drug release and skin permeation from several different liquid crystalline lipid formulations that may be used to control the respective release rates. We have studied the release and permeation through human skin of a water-soluble and amphiphilic drug, propranolol hydrochloride, from several formulations prepared with monoolein and phytantriol as permeation enhancers and controll