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We use semi-grand canonical Monte Carlo simulations to study an electrolytic capacitor with an adsorbed peptide on the electrode surfaces. Only homogeneous peptides are considered, consisting of only a single residue type. We find that the classical double-hump camel-shaped differential capacitance in such systems is augmented by the addition of a third peak, due to the capacitance contribution of
Type-2 diabetes (T2D) is a global disease caused by the inability of pancreatic β-cells to secrete adequate insulin. However, the molecular mechanisms underlying the failure of β-cells to respond to glucose in T2D remains unknown. Here, we investigated the relative contribution of UDP-glucose (UDP-G), a P2Y14-specific agonist, in the regulation of insulin release using human isolated pancreatic is
BACKGROUND: Continuous spike-wave during slow wave sleep syndrome (CSWS) and Landau-Kleffner syndrome (LKS) are two epileptic encephalopathies that present with neurocognitive regression, aphasia, and clinical seizures, typically presenting in children around five years of age. The pathophysiology of these conditions is not completely understood. Some studies suggest a common origin for both. No s
The role of mitochondria in apoptosis is well known; however, the mechanisms linking mitochondria to the proapoptotic effects of proinflammatory cytokines, hyperglycemia, and glucolipotoxicity are not completely understood. Complex Ca2+ signaling has emerged as a critical contributor to these proapoptotic effects and has gained significant attention in regulating the signaling processes of mitocho
OBJECTIVE: While existing evidence supports beneficial cardiovascular effects of glucagon-like peptide 1 (GLP-1), emerging studies suggest that glucose-dependent insulinotropic peptide (GIP) and/or signaling via the GIP receptor may have untoward cardiovascular effects. Indeed, recent studies show that fasting physiological GIP levels are associated with total mortality and cardiovascular mortalit
We propose a low-scale renormalizable trinification theory that successfully explains the flavor hierarchies and neutrino puzzle in the Standard Model (SM), as well as provides a dark matter candidate and also contains the necessary means for efficient leptogenesis. The proposed theory is based on the trinification SU(3)C×SU(3)L×SU(3)R gauge symmetry, which is supplemented with an additional flavo
Hyperfine structure (HFS) measurements of neutron-rich iridium isotopes Ir196,197,198 (Z=77,N=119-121) were performed via in-gas-cell laser resonance ionization spectroscopy at the KEK Isotope Separation System. Magnetic dipole moments μ and isotope shifts were determined from the HFS spectra. The variation of mean-square charge radii and quadrupole deformation parameters of these isotopes were ev
Aging is associated with complex biological changes that can be accelerated, slowed, or even temporarily reversed by biological and non-biological factors. This article focuses on the link between biological aging, psychological stressors, and mental illness. Rather than comprehensively reviewing this rapidly expanding field, we highlight challenges in this area of research and propose potential s
Background Atrial fibrillation (AF) is the most common cardiac arrhythmia, but the pathogenesis is not completely understood. The application of metabolomics could help in discovering new metabolic pathways involved in the development of the disease. Methods and Results We measured 112 baseline fasting metabolites of 3770 participants in the Malmö Diet and Cancer Study; these participants were fre
Bees exemplify flights under bright sunlight. A few species across bee families have evolved nocturnality, displaying remarkable adaptations to overcome limitations of their daylight-suited apposition eyes. Phase inversion to nocturnality in a minority of bees that co-exist with diurnal bees provides a unique opportunity to study ecological benefits that mediate total temporal niche shifts. While
Tumor-associated macrophages (TAMs) continuously fine tune their immune modulatory properties, but how gene expression programs coordinate this immune cell plasticity is largely unknown. Selective mRNA translation, controlled by MNK1/MNK2 and mTOR pathways impinging on eIF4E, facilitates reshaping of proteomes without changes in abundance of corresponding mRNAs. Using polysome profiling developed
For the class of Hardy spaces and standard weighted Bergman spaces of the unit disk, we prove that the spectrum of a generalized Cesàro operator Tg is unchanged if the symbol g is perturbed to g+h by an analytic function h inducing a quasi-nilpotent operator Th, that is, spectrum of Th equals {0}. We also show that any Tg operator that can be approximated in the operator norm by an operator Th w
This thesis presents the study of a position-sensitive scintillation-based detector called the Solid-State Neutron Detector (SoNDe). SoNDe is being developed for cold- and thermal-neutron detection at the small-angle neutron scattering (SANS) instrument SKADI at the European Spallation Source (ESS), currently under construction in Lund, Sweden. The response of the detector scintillator, multi-anod
As an introduction to the rigorous treatment of diffusion encoding in the rest of the book, this chapter gives simple non-mathematical explanations of the relations between the properties of biological tissues and the translational motion of the tissue water with the aim of conveying an intuitive feel of the relevant time and length scales and the level of detail of the information that can be obt
Adiabatic laminar burning velocities and post-flame NO mole fractions for neat and blended ethanol and n-heptane premixed flames were experimentally determined using a heat flux burner and laser-induced fluorescence. The flames were stabilized at atmospheric pressure and at an initial temperature of 338 K, over equivalence ratios ranging from 0.6 to 1.5. These experiments are essential for the dev
Let S(Λ) denote the classical Littlewood–Paley operator formed with respect to a lacunary sequence Λ of positive integers. Motivated by a remark of Pichorides, we obtain sharp asymptotic estimates of the behaviour of the operator norm of S(Λ) from the analytic Hardy space HAp(T) to Lp(T) and of the behaviour of the Lp(T) → Lp(T) operator norm of S(Λ) (1 < p< 2) in terms of the ratio of the lacunar
It is known that for Kn,n equipped with i.i.d. exp (1) edge costs, the minimum total cost of a perfect matching converges to in probability. Similar convergence has been established for all edge cost distributions of pseudo-dimension . In this paper we extend those results to all real positive q, confirming the Mézard-Parisi conjecture in th
Study design: Cross-sectional and longitudinal. Objectives: To (i) describe health-related quality of life (HRQoL) and changes over 6 years in older adults aging with long-term spinal cord injury (SCI) and (ii) investigate how changes in HRQoL are associated with age, gender, and injury characteristics. Setting: Community in southern Sweden. Methods: From the initial 123 participants (years 2011–2
We document that a high level of natural productivity of the ocean - a rich bounty of the sea - has had a positive and persistent impact on economic development since pre-industrial times until today. In addition, we document that it is the bounty of the sea of the ancestors of current populations which drives the persistent effect, not geography per se. We argue that an explanation is that a rich
