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Kinesin is a microtubule-associated motor protein that transports Alzheimer-associated amyloid precursor protein (APP) in neurons. In animal models, impaired kinesin-mediated APP transport seems to enhance formation of the neurotoxic 42 amino acid fragment of beta-amyloid (A beta 42). In man, one study suggests that a polymorphism (rs8702, 56,836G > C) in the kinesin light chain 1 gene (KNS2) may
Background and Purpose - Patients with atrial fibrillation have a varied risk of stroke, depending on age and comorbid conditions. The objective of this study was to assess the predictive value of stroke risk classification schemes and to identify patients with atrial fibrillation who are at substantial risk of stroke despite optimal anticoagulant therapy. Methods - Seven recognized classification
Popular Abstract in Swedish Denna avhandling har den Nya Ekonomiska Geografin, ett mycket snabbt växande forskningsområde inom internationell ekonomi, som utgångspunkt. Avhandlingen består av fyra kapitel; det första är ett introduktionskapitel och de tre följande är teoretiska studier. Avhandlingen kan sammanfattas som följer. I kapitel ett ges en introduktion till forskningsfältet. Det nyspiranThe point of departure of this thesis is the rapidly growing research field known as the New Economic Geography (NEG). It consists of four chapters, one introductory chapter and three self-contained theoretical studies. The chapters may be summarised as follows. The first chapter gives a brief account of the NEG. It explains the soaring interest in the location of economic activity, and it review
Superporous agarose beads have wide, connecting flow pores allowing large molecules such as plasmids to be transported into the interior of the beads by convective flow. The pore walls provide additional surface for plasmid binding thus increasing the binding capacity of the adsorbent. Novel superporous agarose anion exchangers have been prepared, differing with respect to bead diameter, superpore
OBJECTIVE: To elucidate whether differences in the destructive tissue process in cartilage and bone in psoriatic arthritis (PsA) and rheumatoid arthritis (RA) can be recognised by different release patterns of molecular fragments derived from joint tissue. METHODS: Aggrecan, cartilage oligomeric matrix protein (COMP), and bone sialoprotein (BSP) were quantified by immunoassays in knee joint synovi
A detector system for positron emission tomography with time-of-flight capability has been built to serve as an educational tool for undergraduate students. The set-up consists of 48 BaF2 scintillator crystals, each coupled to a fast photo-multiplier tube, mounted in a circular geometry. The analogue detector pulses are handled by fast constant fraction discriminators. A dedicated unit reduces the
SeaWiFS satellite data were employed to demonstrate how the biological conditions in marine and coastal waters may be characterized using the concentration of chlorophyll-alpha (chl-alpha) and dissolved organic carbon (DOC) as the leading parameters. In marine waters the standard algorithms from the SeaWiFS Data Analysis System (SeaDAS) package were used to derive the concentrations, whereas in co
Objectives: Tumor-associated-trypsin inhibitor (TATI) is frequently coexpressed with trypsinogen in tumors. Recently, we found expression of trypsinogens in prostate cancer. We have now studied whether TATI is also expressed in prostate cancer and if TATI expression is associated with Gleason grade, proliferation, and neuroendocrine differentiation. Methods: Expression of TATI and prostate-specifi
We present a functional limit theorem for the empirical level-crossing behaviour of a stationary Gaussian process. This leads to the well-known Slepian model process for a Gaussian process after an upcrossing of a prescribed level as a weak limit in C-space for an empirically defined finite set of functions.We also stress the importance of choosing a suitable topology by giving some natural exampl
After the discovery of space masers based on OH radicals (Weaver et al.cite{Wea65}) and H2O (Cheung et al. cite{Che69}) such microwavelasers have been found to work in more than 100 molecular species(Elitzur cite{Eli92}; Townes cite{Tow97}), as well as in highlyexcited H atoms (Strelnitski et al. cite{Str96}). In the IR region (10mum), the effect of stimulated emission of radiation in t
This study was designed to investigate the effect of inflammation and glucocorticosteroids (GCS) on the content of endothelin-1-like immunoreactivity (ET-LI) in the rat lung. Following intratracheal instillation of Sephadex beads, which induces a long-lasting inflammation in the lung, there was an increase in the lung content of ET-LI measured by RIA. This increase was abolished by locally adminis
