Background: The aim was to evaluate data quality and psychometric properties of an instrument for measurement of health-related quality of life: DISABKIDS Chronic Generic Module (DCGM-37) used in school-aged children with cancer. Methods: All school-children diagnosed with cancer in Sweden during a two-and-a-half year period were invited to participate in the study. Analysis was performed on combi

Background: In the present study the effect of a workplace-oriented intervention for persons on long-term sick leave for clinical burnout, aimed at facilitating return to work (RTW) by job-person match through patient-supervisor communication, was evaluated. We hypothesised that the intervention group would show a more successful RTW than a control group. Methods: In a prospective controlled study

sing an integrative approach in which genetic variation, gene expression, and clinical phenotypes are assessed in relevant tissues may help functionally characterize the contribution of genetics to disease susceptibility. We sought to identify genetic variation influencing skeletal muscle gene expression (expression quantitative trait loci [eQTLs]) as well as expression associated with measures of

Diesel emissions are a major contributor to combustion-generated airborne ambient particles. To understand the role of diesel particulate emissions on health effects, it is important to predict the actual particulate dose deposited in the human respiratory tract, with respect to number, surface area and mass. This is complicated by the agglomerate nature of some of these particles. In this study t

Purpose - The purpose of this paper is to explore how a global supplier network can support and contribute to a market driving strategy. Theoretically, the paper contributes by integrating the market driving strategy and the network approach. IKEA is considered one of the leading market driving firms. The paper studies its activities in establishing supplier networks in Russia and Poland. Design/m

Oxy-fuel combustion is one of the proposed technologies which have the potential to achieve zero CO2 emission. Strontium cobalt based perovskite oxygen carriers are promising materials for air separation with a high selectively for oxygen. And these perovskites can produce an oxygen enriched carbon dioxide stream for an oxy-fuel combustion process. The relatively low oxygen production yield may be

Scatterhoarding birds that cache food items have become an important model system for the study of spatial memory and its correlates in the brain. In particular, it has been suggested that through adaptive specialization, species that cache food have better spatial memory and a relatively larger hippocampus than their non-caching relatives. Critics of this approach, dubbed neuroecology, maintain t

The vast majority of species within the lanternshark genus Etmopterus harbour complex luminescent markings on their flanks, whose functional significance has long remained obscure. Recent studies, however, suggest these enigmatic photophore aggregations to play a role in intraspecific communication. Using visual modelling based on in vivo luminescence measurements from a common lanternshark specie

There is empirical evidence indicating that trust in research is decreasing. If distrust is justified, this is a good thing; if not, it is a cause of concern. A basic question concerns the reasons for, ant the causes of, distrust. Which are they, what do they mean, and how reliable are they? The papers and presentations in this volume focus on external and internal factors contributing to distrus

Investigation into predictors for treatment outcome is essential to improve the clinical efficacy of therapeutic multipotent mesenchymal stromal cells (MSCs). We therefore studied the possible harmful impact of immunogenic ABO blood groups antigens - genetically governed antigenic determinants - at all given steps of MSC-therapy, from cell isolation and preparation for clinical use, to final recip

In this paper, we review our efforts to use quantum mechanical (QM) methods to improve free-energy estimates of the binding of drug candidates to their receptor proteins. First, we have tested the influence of various implicit solvation models on predictions of the ligand-binding affinity. The accuracy of implicit solvation models strongly depend on the parameterisation, but also on the magnitude

Bör filmarkiv främst tillvarata eller förevisa sina samlingar? Noggrant bevara och katalogisera eller visa och sprida dem? Henri Langlois, grundaren av Cinémathèque Français menade att om film aldrig visas, utan endast förvaras i metallburkar, kommer den att sluta som skosmörja. Den digitala utvecklingen förefaller givit honom rätt; bred tillgänglighet till filmens historia är allra viktigast på e

In many countries, current research policy is dominated by managerialism and excellence, manifesting the aim of making universities into national strategic assets in the globally competitive knowledge economy. This article discusses these policy trends and their mirror in recent developments in public funding for academic research, with special attention to Sweden. A review of the language in thre

The influence on the fatigue crack growth behaviour of a short edge crack due to different configurations of a nearby located low angle grain boundary is investigated under quasi-static and plane strain conditions. The geometry is modelled by dislocation dipole elements in a boundary element approach, and the plasticity is modelled by discrete dislocations. The crack is assumed to grow in a single

OBJECTIVE Patients with latent autoimmune diabetes in adults (LADA) express autoantibodies against the 65-kDa isoform of GAD (GADA). Intervention with recombinant human GAD65 formulated with aluminium hydroxide (GAD-alum) given twice subcutaneously to LADA patients at intervals of 4 weeks was safe and did not compromise beta-cell function in a Phase II clinical trial. GADA affinity has been shown

Background: In the everyday surgical life, staff may experience that patients with Alcohol Use Disorders (AUDs) seem reluctant to participate in alcohol intervention programs. The objective was therefore to assess acceptance of screening and intervention as well as adherence to the intervention program among emergency department (ED) and surgical patients with AUDs. Methods: A systematic literatur

With the European Commission making global leadership claims in the field of audit regulation, the content of its 2010 Green Paper on 'Audit Policy: Lessons from the Crisis' warrants careful scrutiny. Important issues raised in the Green Paper include regulatory oversight, competition in the audit market, the dangers of having very few firms with the capacity to audit global transnational corporat