We investigate the prognostic significance of the pro-angiogenic cytokine vascular endothelial growth factor (VEGF), urokinase-type plasminogen activator (uPA), plasminogen activator inhibitor 1 (PAI-1), and S-phase fraction (SPF) for distant disease free survival (DDFS) in 219 premenopausal patients with node-negative breast cancer (NNBC). In univariate analysis significantly shorter DDFS was obs

Laplace motion is a Levy process built upon Laplace distributions. Non Gaussian stochastic fields that are integrals with respect to this process are considered and methods for their model fitting are discussed. The proposed procedures allow for inference about the parameters of the underlying Laplace distributions. A fit of dependence structure is also addressed. The importance of a convenient pa

A program for building level schemes from gamma-spectroscopy coincidence data has been developed. The scheme builder was equipped with two different algorithms: a statistical one based on the Metropolis method and a more logical one, called REMP (REcurse, Merge and Permute), developed from scratch. These two methods are compared both on ideal cases and on experimental gamma-ray data sets. The REMP

It is a hallmark of natural language use that the way we talk about something reflects how it is represented in the mind of our conversation partner. This thesis studies the use and cognitive processing of referring expressions like one in comparison with other expression types in spoken Danish. The cognitive status of referents in other people’s minds can be understood in terms or referential g

Context: Intermittent androgen deprivation (IAD) in prostate cancer (PCa) patients has been proposed to delay development of castration resistance and to reduce the side effects and costs of androgen deprivation therapy (ADT). Objective: This review analyzes (1) the oncologic and quality of life (QoL) results from randomized phase 3 trials comparing IAD and continuous ADT and (2) the prognostic pa

During recent decades, the flows of Muslims migrants to Europe have increased. The integration of these new migrants into the mainstream societies, conflict and multiculturism have been discussed in the book.

Various microchannel heat sinks for dissipating heat loads have received great attention. Wavy channels are recognized to be suitable to enhance the heat transfer, and are successfully applied in heat-exchange devices. In this article, three kinds of water-cooled microchannel heat sinks, such as a rectangular straight microchannel heat sink, a single-layer wavy microchannel heat sink and a double-

We have studied solar variations during the Holocene (i.e., last similar to 11,700 yr) by combining a new model of the Earth's dipole moment with C-14 data from the IntCal04 record and 10 Be data from the GRIP ice core. Joint spectral analysis of the two nuclide records suggests that the periodic behavior of the Sun was particularly pronounced between 6000-4500 yr BP and 3000-2000 yr BP, with domi

The rationale for thrombolysis, the most promising pharmacological approach in acute ischaemic stroke, is centred on the principal cause of most ischaemic strokes: the thrombus that occludes the cerebral artery, and renders part of the brain ischaemic. The occluding thrombus is bound together within fibrin. Fibrinolysis acts by activation of plasminogen to plasmin; plasmin splits fibrinogen and fi

Head and neck squamous cell carcinoma (HNSCC) is known to cause substantial immunosuppression. The present study was designed to characterize blood leukocyte activation in HNSCC and to investigate if the individual activation pattern could be related to tumor progress and survival. The leukocyte activation profile of HNSCC patients and healthy controls was assessed with flow cytometry. HNSCC patie

The coiled-coil protein DivIVA is a determinant of apical growth and hyphal branching in Streptomyces coelicolor. We have investigated the properties of this protein and the involvement of different domains in its essential function and subcellular targeting. In S. coelicolor cell extracts, DivIVA was present as large oligomeric complexes that were not strongly membrane associated. The purified pr

The Swedish reimbursement system operates a system where prices are set based on the expected value to the consumer. This value can be measured using willingness to pay (WTP).

The difficulty of obtaining accurate information about the canopy structure is a current limitation towards higher accuracy in numerical predictions of the wind field in forested terrain. The canopy structure in computational fluid dynamics is specified through the frontal area density and this information is required for each grid point in the three-dimensional computational domain. By using raw

Classical Goodpasture's (GP) syndrome is a monophasic illness characterized by pulmonary hemorrhage and rapidly progressive glomerulonephritis with linear IgG deposition along the glomerular and distal tubular basement membrane and destructive necrotizing diffuse extracapillary crescentic glomerulonephritis. The majority of patients have circulating anti-glomerular basement membrane (GBM) antibodi

This study explores the process of global sourcing through a case of the Swedish furnishing retailer IKEA from an interaction perspective. With a point of departure in the streams of existing research on global sourcing and the internationalization process of firms through networks, a research question is proposed concerning supply network interactions as an influence in the global sourcing proces

Particle image velocimetry is performed on a model of a high pressure homogenizer, scaled for qualitative similarity of the one phase turbulent flow field in a production scale homogenizer. Flow fields in gap entrance, gap and gap outlet chamber are obtained with high resolution. The measurements show gap flow development and formation of a turbulent wall adherent jet when exiting into the outlet