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Interest in precision diagnostics has been fuelled by the concept that early detection of cancer would benefit patients; that is, if detected early, more tumours should be resectable and treatment more efficacious. Serum contains massive amounts of potentially diagnostic information, and affinity proteomics has risen as an accurate approach to decipher this, to generate actionable information that
Purpose: The 4-kallikrein panel, commercially available as the 4Kscore™, is a reflex test for prostate cancer early detection that has been extensively validated in multiple international cohorts. It has been suggested that use of such reflex tests be limited to those with prostate specific antigen less than 10 ng/ml and negative digital rectal examination. We aimed to determine the value of the p
How can music education be enriched by the concept of time? This article is based on the assumption that the present moment, the musical ‘now’, is of the utmost importance not only to the musical performer or listener but to the musical learner and teacher as well. It aims at a philosophical discussion and conceptual clarification of a number of issues of time that are considered to be crucial to How can music education be enriched by the concept of time? This article is based on the assumption that the present moment, the musical ‘now’, is of the utmost importance not only to the musical performer or listener but to the musical learner and teacher as well. It aims at a philosophical discussion and conceptual clarification of a number of issues of time that are considered to be crucial to
Objective: To explore whether children diagnosed with type 1 diabetes during islet autoantibody surveillance through The Environmental Determinants of Diabetes in the Young (TEDDY) study retain greater islet function than children diagnosed through the community. Methods: TEDDY children identified at birth with high-risk human leukocyte antigen and followed every 3months until diabetes diagnosis w
Several different strategies are effective for medical treatment of motor problems in Parkinson's disease (PD). Many guidelines and evidence-based reviews are available, but there is no documentation or consensus in favor of just one treatment strategy. This review presents two algorithms that may be helpful when deciding how to treat a PD patient at various stages of the disease. The first algori
Purpose: To evaluate the influence of socio-economic variables on treatment selection and survival of patients with chronic myeloid leukaemia (CML). Methods: Using information available in population-based Swedish registries, we evaluated indices of health, education and economy from the 980 patients in the Swedish CML register diagnosed between 2002 and 2012. Apart from internal comparisons, five
The first Team Haemophilia Education (THE) Meeting was held on 7–8 May 2015 in Amsterdam, The Netherlands. It aimed to promote the optimal care of patients with haemophilia through education of the multidisciplinary treatment team. This was achieved by reviewing the latest developments in haemophilia management, considering how these can be implemented in the clinic to improve patient care and pro
The WAA apheresis registry was established in 2003 and an increasing number of centers have since then included their experience and data of their procedures. The registry now contains data of more than 74,000 apheresis procedures in more than 10,000 patients. This report shows that the indications for apheresis procedures are changing towards more oncological diagnoses and stem cell collections f
In modern business, standards are too important to be ignored. But what is the rationale for active engagement in long and costly standardization processes when most of those standards will be openly available for a much lower price once they are finalized? What are the strategic motives for engaging in such processes? And even when the motives are clear, how is corporate standardization managed,
The “subsumption of nature” framework focuses on productivity increases and extractive innovations in nature-based industries. In this article, we argue that it can also be employed beyond that context in order to capture the convoluted dynamics of market environmentalism. To substantiate our argument, we draw on recent fieldwork on “Trees for Global Benefits,” a forestry-based offsetting project
This paper will investigate the strategic design decision-making of an in-house designer in a company with a large product portfolio, with respect to how designers plan for future visual alterations of the product. In-house designers have to think strategically about the creation of recognition and differentiation through design because they influence the company's overall strategies. Therefore, w
Unlike the discrete magnet scheme of previous 3rd generation light sources, the magnet elements of the MAX IV storage rings are integrated in precision-machined magnet blocks. By analyzing the rotating coil measurements made by the magnet suppliers, we determined the relative alignment between consecutive magnet elements, which was foundto be <10 μm RMS for all magnet block typesin both horizontal
