FragMAX library identifies ligand-binding sites in nsp10 and nsp14/16 interfaces of SARS-CoV-2
By anna [dot] rasmussen [at] biol [dot] lu [dot] se (Anna Andersson Rasmussen) - published 25 October 2021 By fragment screening using x-ray crystallography we identified four ligands revealing ligand-binding sites in conserved interfaces between SARS-CoV-2 nsp10 and nsp14/nsp16. The nsp14/10 interaction is weak and therefore could be disrupted by small molecules. In a collaborative effort, the Lu
https://www.lp3.lu.se/article/fragmax-library-identifies-ligand-binding-sites-nsp10-and-nsp1416-interfaces-sars-cov-2 - 2025-01-19