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Immune responses activated by LDL particles that have been trapped and oxidized in the arterial wall play an important role in atherosclerosis. Some of these immune responses are protective by facilitating the removal of pro-inflammatory and toxic lipid species formed as result of LDL oxidation. However, should these protective immune responses be insufficient, other more potent pro-inflammatory i
The composition of enclosure materials used in many TV sets sold on the European market has changed significantly since the early 1990s. To determine the potential impact of this change on TV fire safety, a review of European and US TV set fire statistics has been carried out. TV set fires can have internal electrical causes due to faults not apparent at the time of manufacture, simple wear and te
Background: Despite the lack of evidence for effectiveness of the Flexible Assertive Community Treatment (Flexible ACT), the model is considered feasible and is well received by mental health professionals. No current studies have adequately examined mental health professional experiences of working with Flexible ACT. Aims: The aim of this study was to explore mental health professional experience
Municipal wastewater treatment involves mechanical, biological and chemical treatment steps for protecting the environment from adverse effects. The biological treatment step consumes the most energy and can create greenhouse gases. This study investigates municipal wastewater treatment without the biological treatment step, including the effects of different pretreatment configurations, for examp
Objectives In rheumatoid arthritis (RA), seropositive and seronegative disease may be two entities with different underlying pathophysiological mechanisms, long-term outcomes and disease presentations. However, the effect of the conjoint presence of multiple autoantibodies, as proxy for a more pronounced humoral autoimmune response, on clinical phenotype remains unclear. Therefore, this study inve
Regression models are extensively used in many epidemiological studies to understand the linkage between specific outcomes of interest and their risk factors. However, regression models in general examine the average effects of the risk factors and ignore subgroups with different risk profiles. As a result, interventions are often geared towards the average member of the population, without consid
The evidence for associations between area characteristics and entrepreneurship is fairly consistent in most studies. These studies, however, have disregarded the fact that the areas might be constructs that have no effect on the individual differences in entrepreneurship and, furthermore, have conflated entrepreneurship and sole proprietorship, disregarding the impact of area constructs on differ
A model developed to describe long-term cross-shore (CS) exchange of sand and resulting profile evolution at regional scale was employed to simulate the evolution at three different sites. The model consists of modules for calculating dune erosion and overwash, bar-berm material exchange, and dune build-up by wind-blown sand transport, as described in detail in a companion paper (Larson et al., 20
Understanding mechanisms by which a population of beige adipocytes is increased in white adipose tissue (WAT) reflects a potential strategy in the fight against obesity and diabetes. Cyclic adenosine monophosphate (cAMP) is very important in the development of the beige phenotype and activation of its thermogenic program. To study effects of cyclic nucleotides on energy homeostatic mechanisms, mic
Food additives such as emulsifiers are used in increasing quantities in the food industry. The aim of this study was to compare three different emulsifiers (polysorbate 80 (P80), carboxymethyl cellulose (CMC), and β-lactoglobulin (β-lac) with regards to their effect on the stimulation of immune cells and intestinal permeability. The immune stimulatory effects were studied in the myeloid cell line
During the last decade, personal assistance programs have suffered from cutbacks, resulting in a public debate about the future of the service. This debate has largely been framed by public commission estimations of the level of incorrect personal assistance payments, where the idea that circa 10% of all assistance payments are incorrect repeatedly has been used to justify measures designed to dec
Parent-of-origin effects (POE) and sex-specific parental effects have been reported for plasma lipid levels, and a strong relationship exists between dyslipidemia and obesity. We aim to explore whether genetic variants previously reported to have an association to lipid traits also show POE on blood lipid levels and obesity. Families from the Botnia cohort and the Hungarian Transdanubian Biobank (
The integrated nature of the Sustainable Development Goals (SDGs) presents a challenge to implementing the 2030 Agenda. Analytical methods to support decision-makers are often developed without explicitly incorporating decision-makers’ views and experience. Here, we investigate whether existing methods are fit-for-purpose in supporting decision-makers at national and subnational levels. We identif
Entangled logics, which attribute meaning to security, characterise the contemporary security field, bringing about broad comprehensions and ambiguous concepts. Civil defence has (re)surfaced as one such concept that is broadly conceived in the official discourses produced by decision-makers. Since security is ultimately enacted by practitioners, alias decision-takers, their interpretations of con
Pharmaceutical companies regularly fund patient organisations. It is important for patient organisations’ credibility that there should be transparency regarding this financial support. In Europe, the pharmaceutical industry promises to deliver transparency through self-regulation, as opposed to legally binding provisions, but self-regulation’s effectiveness is contested. We compared the industry’
