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Familial renal glycosuria is an inherited disorder resulting in glucose excretion in the urine despite normal blood glucose concentrations. It is most commonly due to mutations in the SLC5A2 gene coding for the glucose transporter SGLT2 in the proximal tubule. Several drugs have been introduced as means to lower glucose in patients with type 2 diabetes targeting SGLT2 resulting in renal glycosuria

Vehicle-to-vehicle (VTV) wireless communications have many envisioned applications in traffic safety and congestion avoidance, but the development of suitable communications systems and standards requires accurate models for the VTV propagation channel. In this paper, we present a new wideband multiple-input-multiple-output (MIMO) model for VTV channels based on extensive MIMO channel measurements

Building owners are encouraged to reduce energy use in order to both contribute to national energy-saving goals and reduce the costs of heating and operation. It is important to choose the most optimal renovation measures available so as to achieve cost-effective energy use while maintaining excellent indoor environments, without sacrificing architectural quality or negatively affecting the enviro

Hypertension is a multifactorial disease in which the interplay of genetic and environmental factors that maintain blood pressure stable throughout life is altered. Cytochrome P450 (CYP)-derived metabolites of arachidonic acid such as epoxyeicosatrienoic acids (EETs) and 20-hydroxyeicosatetraenoic acid (20-HETE), active on vascular tone, endothelial function and renal sodium reapportion, have been

Background: Cancer of unknown primary (CUP) is diagnosed at a metastatic stage but no diagnostic effort is spared to find the primary cancers because these will guide the treatment. Consequently, the diagnostic work-up for CUP is more comprehensive than for any other cancer, resulting in detection of second cancers unrelated to CUP. We want to use the detection rate of second cancers as a measure

The grocery retail industry, with its large product volumes, low margins and fierce competition, is constantly seeking efficiency improvements in its supply chain. The grocery retail industry uses an immense amount of packaging and is directly affected by packaging logistics activities. There is, therefore, a potential for efficiency improvements in the grocery retail supply chain through the inte

The 16O(gamma,pn) reaction has been measured with a resolution high enough to resolve individual low-lying states in the residual 14N nucleus. The relative population of the states provides detailed information about the quantum numbers of the proton-neutron pairs on which photons are absorbed. Partial cross-sections, available to the acceptance of the detector system, have been extracted for the