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Objective: To better understand the seemingly contradictory plasma beta-amyloid (A beta) results in Alzheimer's disease (AD) patients by using a newly developed plasma A beta assay, the INNO-BIA plasma A beta forms, in a multicenter study. Methods: A combined retrospective analysis of plasma A beta isoforms on mild cognitive impairment (MCI) from three large cross-sectional studies involving 643 s

Objective: To locate components and target proteins of relevance for the cAMP and cGMP signaling networks including cAMP and cGMP phosphodiesterases (PDEs), salt-inducible kinases (SIKs), subunits of Na+, K+-ATPases, and aquaporins (AQPs) in the human saccule. Methods: The human saccule was dissected out during the removal of vestibular schwannoma via the translabyrinthine approach and immediately

Sixty genetic loci associated with abdominal obesity, measured by waist circumference (WC) and waist-hip ratio (WHR), have been previously identified, primarily from studies conducted in European-ancestry populations. We conducted a meta-analysis of associations of abdominal obesity with approximately 2.5 million single nucleotide polymorphisms (SNPs) among 53,052 (for WC) and 48,312 (for WHR) ind

In endeavouring to explain the empirical puzzle that the sunk costs of exporting are important, but that, at the same time, trade flows do not, on average, survive for very long, this paper explores the concepts of core and peripheral markets. First, it illustrates that if the importance of sunk costs as well as the expected future returns from exporting are different, depending on whether the exp

System cost reductions and development of standardised plug-and-function systems are some of the most important goals for solar heating technology development. Retrofitting hot water boilers in single-family houses when installing solar collectors has the potential to significantly reduce both material and installation costs. In this study, the TRNSYS simulation models of the retrofitting solar th

This essay aims to discuss the complicacy concerning minority and indigenous rights and its complex relation to other international law instruments. In this research I focus on the situation that occurred when the Bolivian president sent an amendment to the Secretary General concerning the withdrawal of the two articles regarding coca leaf-chewing in the Single Convention on Drugs. The member-stat

Problem: Branding has developed from focusing on particular products, or organizations, to now currently on how to brand countries. When the brand is to represent a whole country, the organization needs to create conditions for employees to be able to “live the brand”. The study takes a new approach by, focusing on communication and sense making, bringing together research on nation branding with

This study explores Malmö's definition of social sustainability. Social sustainability still lacks a universal definition, creating a wide margin of interpretation and free space to act or not to act. The concept has grown as a topic on the political agenda and the City of Malmö has in recent years launched major projects to influence the social sustainability in a positive direction. Among ot

Under 2021 genomfördes ett stort antal M&A-transaktioner på fastighetsmarknaden i Sverige jämfört med tidigare år. Syftet med studien är att studera motiv till M&A-transaktioner på fastighetsmarknaden, hur dessa skapar värde för fastighetsbolagen samt vilka effekter de ger på marknaden. Studien genomfördes genom att läsa litteratur och tidigare forskning på ämnet samt studera M&A-tra

The labor market integration of immigrants in general, and female migrants in particular, remains a central developmental objective for counteracting inequalities within societies across Europe. Previous studies put forth the concept of social capital, the resources linked to an individual's network of social connections, to explain immigrants’ diverging labor market trajectories. Policy-maker

Att göra företagstransaktioner “work” är en av de svåraste uppgifterna i näringslivet. Due diligence vilket brukar kallas ”företagsbesiktning” på svenska är ett sätt att samla in och granska information och risker om ett företag. Det finns olika former av due diligence, varav de sedvanliga formerna är kommersiell, financial och legal due diligence. Både köpare eller säljare anlitar ofta en advokat