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For the assessment of value of new therapies in healthcare, Health Technology Assessment (HTA) agencies often review the cost per Quality-Adjusted Life-Years (QALY) gained. Some HTAs accept a higher cost per QALY gained when treatment is aimed at prolonging survival for patients with a short expected remaining lifetime, a so called End-Of-Life (EoL) premium. The objective of this study is to elici
This paper is concerned with the authority of written documents and how these artefacts work as governance devices. Networked authority is introduced as a concept to elucidate how documents accumulate formal power in a collaborative process, where several formally independent but informally interdependent organisations together point out the direction of regional public transport planning in the f
The temperature distribution in concrete structures varies as a result of fluctuations in solar radiation, air temperature, wind speed and long-wave radiation. Variations in temperature may cause longitudinal and transverse movements. If these movements are restrained, stresses and strains can be induced, which may contribute to cracking in the structure. To predict such thermal actions in a hollo
PFAAs emission to the environment represents a potential risk to human health. Although, long-term global scale fate and transport models have been used to investigate potential trends in environmental levels, temporal trends and transports mechanisms of PFAAs are not fully understood. Due to high solubility in water, the behaviour of PFAAs in soil is important for environmental fate estimation an
Denna studie analyserar tillämpningen av artikel 22 i Europaparlamentets och rådets förordning (EU) 2016/679 (GDPR) på kreditupplysningsverksamhetens kreditbedömning i form av kreditbetyg. Fokus är att identifiera juridiska möjligheter och utmaningar i dessa processer. Särskild vikt läggs vid transparensbestämmelserna i artiklarna 13–15 i GDPR. Automatiserade verktyg för kreditupplysningar är baseThis study analyzes the application of Article 22 of Regulation (EU) 2016/679 of the European Parliament and of the Council (GDPR) to the credit assessment practices of the credit reporting businesses in the form of credit score. The main focus is on identifying the legal opportunities and challenges in these processes. Particular attention is paid to the transparency provisions in Articles 13–15
Decision biases reinforce firms’ tendency to develop innovations based on narrow economic motivations. Consequently, sustainability-oriented ideas explicitly targeting social and environmental issues are easily discarded in idea selection when trade-offs between economic and sustainability values are faced. Given the so far limited knowledge about how sustainability-oriented ideas are developed an
Pioneering studies performed over the past few decades demonstrate links between epigenetics and type 2 diabetes mellitus (T2DM), the metabolic disorder with the most rapidly increasing prevalence in the world. Importantly, these studies identified epigenetic modifications, including altered DNA methylation, in pancreatic islets, adipose tissue, skeletal muscle and the liver from individuals with
The impact of climate change on the deterioration of reinforced concrete elements have been frequently highlighted as worthy of investigation. This article addresses this important issue by presenting a time-variant reliability analysis to assess the effect of climate change on four limit states; the probabilities of corrosion initiation, crack initiation, severe cracking, and failure of a simply
Current scholarship on race in Europe has described race as an “absent presence”. However, little is known about the dynamics of the absentness and presentness of race, including how various social processes operating at distinct levels (e.g., supranational and national) influence the uses of race and ethnicity concepts. We begin addressing this gap by examining racialised pharmaceutical regulatio
Dysphagia, or difficulty swallowing, affects 10–30 % of persons above 65 years old. Texture-modified, easy-to-swallow, puree-like food in the form of timbales is usually served to this group of patients. Due to the characteristics of timbale, its appearance only remotely reminds of the original ingredients, leading to reduced appetite, reduced nutrition intake, and even malnutrition. 3D food print
