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Background: Treatment of primary breast cancer is individualised and adjuvant systemic treatment is delivered to most patients after surgery. Oestrogen receptor (ER) status and progesterone receptor status (PR) can define patients who would benefit from adjuvant endocrine therapy with tamoxifen (TAM) alone or as chemo-endocrine therapy. In spite of adjuvant treatment with TAM, some patients with h

“Diversify or die” is a recurring and rather dramatic call for organizations to recruit, retain and manage a demographically diverse workforce, advocated by the business case for diversity, also known as diversity management philosophy. Diversity management places diverse social identities at the heart of organizational success and has gained much attention from management consultants and managers

The human side of mergers and acquisitions (M&A) – with focus particularly on resistance - has puzzled scholars for decades. Still, there is little discussion as regards to how the concept should be defined or understood. Often expressions of resistance, rather than its actual content, are described. What do personnel actually oppose? In this dissertation, the content, process, and context of

Hypoglycaemia is an acute complication to insulin-treatment in type 1 diabetes mellitus, which affects many physiological parameters, deteriorates the cognitive function, and may lead to death. The aim of this thesis was to study nerve function, cognitive function and cerebral blood flow during and after hypoglycaemia in healthy subjects and to study certain aspects of a fall in blood glucose in p

Huntington's disease (HD) is a hereditary neurodegenerative disorder presenting with chorea, dementia and extensive striatal neuronal death. The mechanism through which the widely expressed mutant huntingtin mediates striatal neurotoxicity is unknown. Excitotoxicity, i.e. calcium-dependent cell death induced by activation of NMDA receptors, has been hypothesized to play an important role in HD. Ou

All guidelines recommend short-acting inhaled beta 2-adrenoceptor agonists as the first-line drugs in acute asthma attacks and inhaled corticosteroids as the drugs of choice when regular daily treatment is needed. Short-acting inhaled beta 2-adrenoceptor agonists are not effective in reducing nocturnal awakenings because of their short duration of action. In addition there has been an intense deba

Since July 2007, the world economy has experienced a severe financial crisis that originated in the U.S. housing market. Subsequently, the crisis has spread to financial sectors in European and Asian economies and led to a severe worldwide recession. The existing literature on financial crises rarely distinguishes between factors that create the original strain on the financial sector and factors

Although phenological matching between two and three trophic interactions has received some attention, it has largely been disregarded in explaining the lack of strong cascade dynamics in terrestrial systems. We studied the response of the specialist seed predator, Paroxyna plantaginis (Tephritidae) and associated generalist parasitoids (Chalcidoidea) to controlled fertilisation of individuals of

A new hygroscopic tandem differential mobility analyzer (H-TDMA) has been constructed at Lund University within the frameworks of the EU FP6 Infrastructure Project EUSAAR (www.eusaar.org). The aim of this coordinated H-TDMA development is to design and evaluate a new generation of H-TDMAs that are capable of conducting long term measurements of the hygroscopic growth and state of mixing of sub-mic

This paper develops a theoretical model of the family as producer of health- and social capital. There are both direct and indirect returns on the production and accumulation of health- and social capital. Direct returns (the consumption motives) result since health and social capital both enhance individual welfare per se. Indirect returns (the investment motives) result since health capital incr

The rarefaction technique applied to fossil pollen sequences for analyzing palynological richness, interpreted as a signal of biological diversity of landscapes and vegetation, has been developed since 1988. Errors including population evenness and vegetation disturbance have been considered in this study. Information from two sites is discussed, one with a pollen diagram covering Late-Glacial (La

Malignant hyperthermia susceptibility is diagnosed using an in vitro contracture test (IVCT). In families in which the mutation is known, genetic tests are also available. The inheritance pattern is regarded as autosomal dominant, which predicts equal proportions of men and women affected. The aim of this study was to investigate whether there were sex differences in the diagnostic outcome of the

The severity of lung disease in cystic fibrosis (CF) may be related to the type of mutation in the cystic fibrosis transmembrane conductance regulator (CFTR) gene, and to environmental and immunological factors. Since pulmonary disease is the main determinant of morbidity and mortality in CF, it is important to identify factors that can explain and predict this variation. The aim of this longitudi