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The matter of white matter in Alzheimer's disease. -On white matter disease from neuropathology and neuroimaging to clinical presentation.

Alzheimer's disease (AD) is the most prevalent type of dementing disorder. The cortical pathology of AD has been recognized for almost a century. In later years, an associated pathological feature of AD has been identified which affects the white matter. This white matter disease (WMD), defined in the microscope, consists of a subtotal tissue loss of the white matter structural components. WMD is

MMP-26 mRNA and estrogen receptor alpha co-expression in normal and pathological endometrium

OBJECTIVE: To examine the expression pattern of matrix metalloproteinase-26 (MMP-26) mRNA and estrogen receptor-alpha (ER alpha) in normal, hyperplastic, premalignant and malignant endometrial tissue. DESIGN: Experimental study. SETTING: Department of Obstetrics and Gynecology of the Palacky University Medical School and University Hospital, Olomouc, Czech Republic, Department of Obstetrics and Gy

Management of bile duct calculi : a study with special reference to long-term outcome

Open surgical versus endoscopic treatment of CBD stones in 80 elderly not cholecystectomized patients revealed a similar efficacy of stone clearance and early major complication rates, as well as total complication rates and hospitalization time in the two groups during 5 to 9 years follow-up. However, more patients in the endoscopically treated group died from heart disease, suggesting surgery to

Consumption of dairy products in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort: data from 35955 24-hour dietary recalls in 10 European countries

Objectives: To describe and compare the consumption of dairy products in cohorts included in the European Prospective Investigation into-Cancer and Nutrition (EPIC). Methods: Data from single 24-hour dietary recall interviews collected through a highly standardised computer-based program (EPIC-SOFT) in 27 redefined centres in 10 European countries between 1995 and 2000. From a total random sample

Reducing transportation emissions – a reaction to stakeholder pressure or a strategy to increase competitive advantage

Purpose: This paper evaluates why companies reduce transportation emissions by examining the relative importance of external drivers vs. internal motives for companies in considering CO2 emissions in freight transportation. Design/methodology/approach: A framework is suggested that captures internal, competitiveness-driven motives and external, stakeholder-driven drivers for companies seeking to

Questioning the Causal Link between Maternal Smoking during Pregnancy and Offspring Use of Psychotropic Medication: A Sibling Design Analysis.

A recent population-based, longitudinal study from Finland observed a dose-response association between smoking during pregnancy (SDP) and use of psychotropic medications in exposed children and young adults. However, this association may be confounded by unmeasured familial characteristics related to both SDP and offspring mental health. Consequently, we aim to investigate the effect of SDP by me

D-arabinitol in the diagnosis of invasive candidiasis

Invasive candidiasis (IC) is a serious condition and timely diagnosis with early initiation of antifungal therapy is imerative for improving outcomes. Arabinitol is a sugar alcohol with two stereoisomers, D-arabinitol (DA) and L-arabintiol (LA). Several pathogenic Candida species produce DA in vitro and high DA levels have been detected in serum and urine in patients with IC. Renal dysfunction aff

Trends in smoking behaviour between 1985 and 2000 in nine European countries by education

Objective: To examine whether trends in smoking behaviour in Western Europe between 1985 and 2000 differed by education group. Design: Data of smoking behaviour and education level were obtained from national cross sectional surveys conducted between 1985 and 2000 (a period characterised by intense tobacco control policies) and analysed for countries combined and each country separately. Annual tr

Polybrominated diphenyl ethers in aircraft cabins - A source of human exposure?

Commercial aircrafts need a high degree of fire protection for passenger safety. Brominated flame retardants (BFRs), including polybrominated diphenyl ethers (PBDEs), may be used for this purpose. Because PBDEs readily absorb to dust particles, aircraft crew and passengers may receive significant PBDEs exposure via inhalation. The aims of this work were to assess whether PBDEs could be found in ai

Defining Peer-to-peer Learning - from an Old Art of Practice to a New Mode of Forest Owner Extension?

This paper explores the concept of peer-to-peer learning (P2PL) in the context of North-European small-scale forest owners. The aim is to develop a framework for initiating new and evaluating already existing forest owners’ P2PL communities. Design: Previous studies of peer-learning are used to determine and justify eight dimensions for forest owners’ P2PL. To demonstrate and test the operability