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Study of the role of functional variants of SLC22A4, RUNX1 and SUMO4 in systemic lupus erythematosus

Background: Functional polymorphisms of the solute carrier family 22, member 4 (SLC22A4), runt related transcription factor 1 (RUNX1) and small ubiquitin- like modifier 4 (SUMO4) genes have been shown to be associated with several autoimmune diseases. Objective: To test the possible role of these variants in susceptibility to or severity of systemic lupus erythematosus (SLE), on the basis that com

Time to diagnosis, of melanoma: same trend in different continents

Background: Patients and physicians both play an important role in the diagnosis of malignant melanoma. Objective: The purpose of this study was to assess important factors of delay in diagnosis at different centers and on three continents. Methods: Between October 2001 and October 2002, patients with histologically confirmed invasive melanoma were included in the study and given an established qu

Better Walking Performance in Older Children With Cerebral Palsy.

BACKGROUND: Children with cerebral palsy (CP) often walk with a slower speed and a higher energy cost. Their walking performance and choice of mobility method may vary in different environments. Independent mobility is important for activity and participation. QUESTIONS/PURPOSES: We described walking performance at different distances and environments in relation to gross motor function, CP subtyp