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Breathlessness and incidence of COPD, cardiac events and all-cause mortality : A 44-year follow-up from middle age throughout life
Spectacle use after routine cataract surgery and vision-related activity limitation
Late leakage after anterior resection : a defunctioning stoma alters the clinical course of anastomotic leakage
Novel insights into the regulation of insulin secretion by GLP-1, GIP and glucagon
There are many contributing factors to the development of type 2 diabetes, however, failure of beta-cells to sufficiently secrete insulin is the key component. The underlying mechanism of beta-cell failure is not fully established. In this thesis, we examined the role of high glucagon levels, i.e. hyperglucagonemia, for the development of beta-cell dysfunction in pre-diabetic mice. We found that i
Validity of self-reported criminal justice system involvement in substance abusing women at five-year follow-up
Background: Few studies have compared self-reported criminal behaviour with high-quality databases of criminal offences and judicial sanctions. Self-reported problems from drug abusers are generally believed to be valid. We assessed the validity of self-reported theft, drug offences and prison sentences from a five-year follow-up of female substance abusers who were originally treated in a compuls
Lower Limb Amputation in Patients with Vascular Disease
Exploring food concepts for the prevention of type 2 diabetes
There is currently a dramatic and global increase in obesity, type 2 diabetes (T2D) and associated metabolic disorders. T2D can be delayed or prevented in individuals at risk and identifying and developing new food concepts for the prevention of obesity and T2D is of utmost importance. This thesis describes our work on exploring new food concepts for the prevention of T2D. We have used 3T3-L1 adip
Exocytosis in Type 2 Diabetes- Functional and genetic studies of hormone secretion
Type 2 Diabetes (T2D) is characterized by dysregulated beta-and alpha-cell hormone secretion leading to elevated blood glucose levels. Several proteins are crucial in maintaining exocytosis of the hormone-containing granules such as Syntaxin1A (Stx1A), SNAP25, Munc-18 (Stxbp1) and the family of Synaptotagmins (Syts). The aim of this thesis has been to investigate functional and genetic events that
Taming killer cells may halt diabetes progression
Preclinical studies in mice suggest that the natural killer cell receptor NKp46 may be a new molecular target for delaying the progression of type 1 diabetes by interfering with unexpected natural killer cell-mediated recognition of pancreatic beta cells.
Allograft bone in hip revision: the effect of locally applied pharmacological treatment.
At what hip fracture risk is it cost-effective to treat? International intervention thresholds for the treatment of osteoporosis
Association of TCF7L2 variation with single islet autoantibody expression in children with type 1 diabetes.
The transcription factor 7-like 2 (TCF7L2) gene has the strongest genetic association with type 2 diabetes. TCF7L2 also associates with latent autoimmune diabetes in adults, which often presents with a single islet autoantibody, but not with classical type 1 diabetes.
WDR12, a Member of Nucleolar PeBoW-Complex, Is Up-Regulated in Failing Hearts and Causes Deterioration of Cardiac Function.
In a recent genome-wide association study, WD-repeat domain 12 (WDR12) was associated with early-onset myocardial infarction (MI). However, the function of WDR12 in the heart is unknown.
The Effect of Snuff (Smokeless Tobacco) on Disease Activity and Function in Rheumatoid Arthritis: Experiences From the Better Anti-Rheumatic FarmacOTherapy, a Longitudinal Multicenter Study on Early Rheumatoid Arthritis.
An Audit-Based, Infectious Disease Specialist-Guided Antimicrobial Stewardship Program Profoundly Reduced Antibiotic Use Without Negatively Affecting Patient Outcomes.
Background. Antimicrobial stewardship programs are increasingly implemented in hospital care. They aim to simultaneously optimize outcomes for individual patients with infections and reduce financial and health-associated costs of overuse of antibiotics. Few studies have examined the effects of antimicrobial stewardship programs in settings with low proportions of antimicrobial resistance, such as
Population-based study of antiepileptic drug exposure in utero-Influence on head circumference in newborns
Maternal drug use and infant cleft lip/palate with special reference to corticoids
Arbetsgivares primära förhandlingsskyldighet enligt 11 § medbestämmandelagen
The employer is obligated to call for negotiation on his own initiative, before he makes decisions in questions, which constitute important changes of the employer’s business or of the worker’s working conditions and terms of employment. The obligation to negotiate is reserved to the organisations, which the employer has collective agreements with. But what does the concept of important changes me
Chatt - ett nytt sätt att kommunicera med bibliotekarien
This thesis presents a new way of providing library users with reference services, namely chat (text based digital reference service in real time). Our research questions focus on the role of reference service, a comparison of chat reference to other reference forms, and the interest for real-time, digital reference. Our literature review covered the areas of digital reference and reference theory
