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Vatten är nödvändigt för att den mänskliga kroppen ska fungera. För att vattnet ska kunna transporteras in och ut ur cellerna behöver det komma igenom cellmembranet, vilket det bland annat gör via en särskild klass av proteiner som fungerar som vattenkanaler – akvaporinerna. Akvaporiner finns överallt i vår kropp och är viktiga för många biologiska funktioner såsom metabolism och återfuktning av hAquaporins (AQPs) are a family of transmembrane proteins, mainly mediating water transport over the cell membrane in various parts of the body. The aquaporins AQP3 and AQP7 are both part of the subfamily aquaglyceroporins, which apart from water conduct small non-polar solutes such as glycerol. AQP3 overexpression or malfunction has been connected to skin and lung cancer and potential AQP3 inhibit

This thesis explores the construction and negotiation of Tibetan identities through the lens of native Tibetan cinema, with a focus on Pema Tseden’s Balloon (2019). Drawing on theories of identity as construction, cultural hybridity, and minor cinema, the study examines how cinematic narratives and audience interpretations intersect to produce a nuanced understanding of Tibetan identities in conte

Background: Public trust is central to the collection of genomic and health data and the sustainability of genomic research. To merit trust, those involved in collecting and sharing data need to demonstrate they are trustworthy. However, it is unclear what measures are most likely to demonstrate this. Methods: We analyse the ‘Your DNA, Your Say’ online survey of public perspectives on genomic data

Shelterbelts (or windbreaks) can effectively improve the microclimate and soil conditions of adjacent farmland and thus increase crop yield. However, the individual contribution of these two factors to yield changes is still unclear since the short-term effect from the microclimate and the accumulated effect from the soil jointly affect crop yield. The latter (soil effect) is supposed to remain af

The widely accepted “Milankovitch theory” explains insolation-induced waxing and waning of the ice sheets and their effect on the global climate on orbital timescales. In the past half century, however, the theory has often come under scrutiny, especially regarding its “100-ka problem.” Another drawback, but the one that has received less attention, is the “monsoon problem,” which pertains to the

Hydrological processes in a watershed consist of multiple sub-processes (such as plant growth, evapotranspiration, water yield, and soil–water balance) that have complex interactions. The common practice of calibrating hydrological models against only a single variable (e.g., streamflow) can lead to parameter uncertainty (also known as equifinality), resulting in significant uncertainties in the r

This thesis challenges the prevailing firm-consumer/customer-centric and dyadic perspective that prevails within the brand equity literature, which is based on a linear, straightforward stimulus-response approach to the creation of brand value. Leaning on the literature on interorganisational relationships, stakeholder theory, market emergence/market driving, and firm internationalisation, which s

What do we gain from labeling certain norms of social organization law? This question provides the backdrop against which this chapter will examine the works of Leon Petrażycki and Eugen Ehrlich, two of the founders of legal sociology who devised concepts of law broader than state law. In the course of this examination we shall also assess the relevance of Petrażycki’s 'intuitive law' and Ehrlich’

OBJECTIVE: To identify ways that provision of hemophilia care can be maximized at the local level, irrespective of available resources or cultural or geographic challenges.METHODS: The SHIELD group used its multinational experience to share examples of local initiatives that have been employed to deliver optimal hemophilia care.RESULTS: The examples were reviewed and categorized into four key them

Although climate change and international trade are interdependent, policy-makers often address the two topics separately. This may inhibit progress at the intersection of climate change and trade and could present a serious constraint for global climate action. One key risk is carbon leakage through emission outsourcing, i.e. reductions in emissions in countries with rigorous climate policies bei

Polycentrism has gradually become a newly emergent dimension of global urbanization. Many countries worldwide have tailored plans suited to functional polycentricity, in light of the prevalent “ghost cities” or “empty towns” as lessons from the morphologically polycentric development practices. However, the subject of defining and measuring functional polycentricity is still in an initial developm

Palaeomagnetic data are used to study the configurations of continents during the Proterozoic. Applying stringent reliability criteria, the positions of the continents at 12 times in the 2.45- to 1.00-Ga period have been constructed. The continents lie predominantly in low to intermediate latitudes. The sedimentological indicators of palaeoclimate are generally consistent with the palaeomagnetic l

Ending the use of unabated coal power is a key climate change mitigation measure. However, we do not know how fast it is feasible to phase-out coal on the global scale. Historical experience of individual countries indicates feasible coal phase-out rates, but can these be upscaled to the global level and accelerated by deliberate action? To answer this question, we analyse 72 national coal power p

BACKGROUND: Dysbiosis of the oral mycobiome has been linked to some diseases, including cancers. However, the role of oral fungal communities in nasopharyngeal carcinoma (NPC) carcinogenesis has not previously been investigated.METHODS: We characterized the oral salivary fungal mycobiome in 476 untreated incident NPC patients and 537 population-based controls using fungal internal transcribed spac

Climate change mitigation requires rapid expansion of low-carbon electricity but there is a disagreement on whether available technologies such as renewables and nuclear power can be scaled up sufficiently fast. Here we analyze the diffusion of nuclear (from the 1960s), as well as wind and solar (from the 1980-90s) power. We show that all these technologies have been adopted in most large economie