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Drivers for global agricultural land use change: The nexus of diet, population, yield and bioenergy
The nexus of population growth and changing diets has increased the demands placed on agriculture to supply food for human consumption, animal feed and fuel. Rising incomes lead to dietary changes, from staple crops, towards commodities with greater land requirements, e.g. meat and dairy products. Despite yield improvements partially offsetting increases in demand, agricultural land has still been
Heparan sulfate 3-O-sulfotransferase isoform 5 generates both an antithrombin-binding site and an entry receptor for herpes simplex virus, type 1
Heparan sulfate 3-O-sulfotransferase transfers sulfate to the 3-OH position of a glucosamine residue of heparan sulfate (HS) to form 3-O-sulfated HS. The 3-O-sulfated glucosamine residue contributes to two important biological functions of HS: binding to antithrombin and thereby carrying anticoagulant activity, and binding to herpes simplex viral envelope glycoprotein D to serve as an entry recept
Activation of Hormone-sensitive Lipase Requires Two Steps, Protein Phosphorylation and Binding to the PAT-1 Domain of Lipid Droplet Coat Proteins
Lipolysis is an important metabolic pathway controlling energy homeostasis through degradation of triglycerides stored in lipid droplets and release of fatty acids. Lipid droplets of mammalian cells are coated with one or more members of the PAT protein family, which serve important functions in regulating lipolysis. In this study, we investigate the mechanisms by which PAT family members, perilip
Chromosome 19 Annotations with Disease Speciation - A First Report from the Global Research Consortium
Who Needs the Classics? - On the Relevance of Classical Legal Sociology for the Study of Current Social and Legal Problems
What do we gain from labeling certain norms of social organization law? This question provides the backdrop against which this chapter will examine the works of Leon Petrażycki and Eugen Ehrlich, two of the founders of legal sociology who devised concepts of law broader than state law. In the course of this examination we shall also assess the relevance of Petrażycki’s 'intuitive law' and Ehrlich’
Common themes and challenges in hemophilia care : a multinational perspective
OBJECTIVE: To identify ways that provision of hemophilia care can be maximized at the local level, irrespective of available resources or cultural or geographic challenges.METHODS: The SHIELD group used its multinational experience to share examples of local initiatives that have been employed to deliver optimal hemophilia care.RESULTS: The examples were reviewed and categorized into four key them
The risk of carbon leakage in global climate agreements
Although climate change and international trade are interdependent, policy-makers often address the two topics separately. This may inhibit progress at the intersection of climate change and trade and could present a serious constraint for global climate action. One key risk is carbon leakage through emission outsourcing, i.e. reductions in emissions in countries with rigorous climate policies bei
Multiscale identification of urban functional polycentricity for planning implications : An integrated approach using geo-big transport data and complex network modeling
Polycentrism has gradually become a newly emergent dimension of global urbanization. Many countries worldwide have tailored plans suited to functional polycentricity, in light of the prevalent “ghost cities” or “empty towns” as lessons from the morphologically polycentric development practices. However, the subject of defining and measuring functional polycentricity is still in an initial developm
Improved soil hydrological modeling with the implementation of salt-induced freezing point depression in CoupModel : Model calibration and validation
Soil freezing/thawing is an important mechanism to control soil water and heat redistribution in mid-to-high latitudes. Salt in the agricultural soil from mid-to-high latitudes can alter characteristics of soil freezing/thawing cycle and then affect soil thermal and hydrological processes in winter and finally cause salinization in spring. To quantify the impacts of soil salinization on soil water
Building Knowledge Graphs : Processing Infrastructure and Named Entity Linking
Things such as organizations, persons, or locations are ubiquitous in all texts circulating on the internet, particularly in the news, forum posts, and social media. Today, there is more written material than any single person can read through during a typical lifespan. Automatic systems can help us amplify our abilities to find relevant information, where, ideally, a system would learn knowledge
Greenhouse Gas Emissions and Energy Payback Time for multi- and mono-Si Photovoltaic Systems - A Study on Solar Energy from Photovoltaic Systems Located in Sweden
Solceller – en miljövänlig energikälla? Miljöförstöring i form av växthusgasutsläpp är en gigantisk utmaning som mänskligheten står inför och vi måste agera NU! Solceller innebär en fantastisk möjlighet att utvinna stora mängder “ren” energi från solen. Men hur miljövänliga är egentligen solceller och är det ett effektivt alternativ i Sverige? Varje timme träffas Jorden av tillräckligt mycket eClimate change is one of the greatest environmental challenges at the present time and is currently an issue affecting the entire global population. Alternative renewable energy sources are vital to be able to deal with this challenge. Solar energy is one of the most promising renewable energy sources and is therefore also one of the fastest growing industries in this field. However, solar energy
En framtida IS-tribunal – tomma ord eller en reell möjlighet?
Islamiska Staten har de senaste fem åren orsakat oerhört mycket smärta och sorg. Krigsförbrytelser, brott mot mänskligheten och folkmord ska ha begåtts i de områden rörelsen kontrollerat i Irak och Syrien. Nu när kalifatets sista fästen besegrats står det internationella samfundet inför en ny utmaning; hur och var ska de ansvariga individerna straffas? Vissa politiker har numera hävdat att en IS-tDuring the past five years, the Islamic State has been responsible for a large amount of pain and suffering. War crimes, crimes against humanity and genocide have been committed in the areas the group controlled in Iraq and Syria. Now as the Kalifate’s last strongholds have been defeated, the international community stands before a new task; how and where shall the individuals responsible be punis
The Establishment of Macrobenthic Faunal Communities in Planted Mangroves of Increasing Age
Mangroveskogens ekosystem är ett tropiskt kustsamhälle bebott av organismer anpassade till den stressfulla miljön i tidvattenszonen. Mangroveskogen har på senare år blivit erkänd för de viktiga ekosystemtjänsterna den erbjuder. Trotts detta hotas den av mänskliga aktiviteter, och en tredjedel av världens naturliga mangroveskog uppskattas redan ha gått förlorad. Ansträngningar har gjorts för att beThe mangrove ecosystem is a tropical coastal community inhabited by organisms adapted to the stressful environment of the tidal zone. Mangrove ecosystems has in recent years been noted for the important ecosystem services they offer. Still, they are threatened by anthropogenic activities and it has been estimated that a third of the world’s natural mangrove cover has already been lost. Efforts hav
Tungmetaller i en sedimentkärna från en sjö norr om polcirkeln-möjliga orsaker till haltvariationer i vertikalled
Hur har föroreningar förändrats över tiden i nordligaste delen av Sverige? Om höga halter tungmetaller finns, vilka kan vara orsakerna till dessa? En resa från södra Skåne till norra Lappland har visat att de flesta metaller i sedimentet från en sjö har minskat på senare år, Hg samt Arsenik har dock ökat. Detta beror troligtvis på minskad användning av fossila bränslen samt gruvdriften i norr.Changes in the accumulation of heavy metals (Cd, Cu, Hg, Fe, Mn, Ni, Pb, Zn), arsenic (As), and selenium (Se) in sediment of pristine lake in northern Sweden were studied by making measurements at different depths in a sediment core. The sediment core was extracted from the deepest part of the lake Sautusjärvi, close to the village Jukkasjärvi. The sediment samples were transported in a cooler to
Optimizing the locations of bike-sharing stations using GPS-based trip data: A Spatio-temporal demand coverage approach
Shared micro-mobility services are increasingly embraced by cities around the world in recent years. Their benefits over other transportation modes in certain frames encourage traffic/urban planners, public authorities to establish such systems in urban areas. However, planning the placement, size and operation of such beneficial micro-mobility mode is a vital issue that concerns designers. Severa
An anthem for Europe: Comparing historical appropriations of Beethoven's Ode to Joy
Since its composition two centuries ago in 1824, Beethoven’s Ninth Symphony (Ode to Joy) has been heralded the world over not only as a great work of art, but also as a symbol of political importance. In Germany, it was lionised as the embodiment of a national spirit, first during the Franco-Prussian war, then as a prize of the Nazi repertoire; in Rhodesia, it became the national anthem of a far-r
Toward finding peremptory norms and obligations erga omnes
Jus cogens norms and obligations erga omnes are concepts within international law that are often used to reinforce legal claims. This thesis aims to assess to what extent invoking these concepts, along with their reinforcing capabilities, is justified in specific cases. In order to achieve this, the thesis first gives an overview of the theoretical debate surrounding the concepts of jus cogens no
The distribution of shorebirds and their benthic food underscore the importance of heterogeneity in habitat conservation
Distribution patterns of resources and their role in determining species distribution are not only fundamental to the understanding of ecological patterns, but also of practical significance in conservation management. Shorebirds are experiencing precipitous declines globally, especially along the East Asian-Australasian Flyway (EAAF), where the major threats include the loss and degradation of ti
Modelling Time-Dependent Effects for Segmentally Constructed Prestressed Concrete Bridges
Tidsberoende effekter, såsom krypning, krympning och stålrelaxation, är ofta svåra att prediktera när det kommer till förspända betongkonstruktioner. Krypning som ett fenomen är komplicerat och förenklas därför i gällande byggnormer (Eurocode), för att underlätta konstruktörens arbete. När det gäller etappvis spännarmerade betongbroar har dessa förenklingar visat sig ge felaktiga prognoser av de tLong-term effects, such as creep, shrinkage, and steel relaxation, are often difficult to predict for prestressed concrete structures. Creep as a phenomenon is complicated to describe and is therefore simplified in the current building standards, to better accommodate the designer. When dealing with segmentally constructed prestressed concrete bridges, these simplifications have shown to provide i
